Long noncoding RNAs in lipid metabolism: literature review and conservation analysis across species DOI Creative Commons
Kévin Muret,

Colette Désert,

Laëtitia Lagoutte

и другие.

BMC Genomics, Год журнала: 2019, Номер 20(1)

Опубликована: Ноя. 21, 2019

Abstract Background Lipids are important for the cell and organism life since they major components of membranes, energy reserves also signal molecules. The main organs synthesis storage liver adipose tissue, both in humans more distant species such as chicken. Long noncoding RNAs (lncRNAs) known to be involved many biological processes including lipid metabolism. Results In this context, paper provides most exhaustive list lncRNAs metabolism with 60 genes identified after an in-depth analysis bibliography, while all “review” type articles a total 27 genes. These mainly described human or mice only few them have precise mode-of-action. Because these still named non-standard way making study tedious, we propose standard name according rules dictated by HUGO consortium. Moreover, about 10% which conserved between mammals chicken 2% fishes. Finally, demonstrated that two lncRNA were wrongly considered literature 3′ extensions closest coding gene. Conclusions Such catalogue can participate understanding regulators; it useful better understand genetic regulation some diseases (obesity, hepatic steatosis) traits economic interest livestock (meat quality, carcass composition). We no doubt first set will rapidly enriched coming years.

Язык: Английский

Pathophysiology of Atherosclerosis DOI Open Access

Shifa Jebari‐Benslaiman,

Unai Galicia-García,

Asier Larrea‐Sebal

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(6), С. 3346 - 3346

Опубликована: Март 20, 2022

Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which leading cause of mortality worldwide. initiated by endothelium activation and, followed a cascade events (accumulation lipids, fibrous elements, and calcification), triggers vessel narrowing inflammatory pathways. The resultant atheroma plaque, along with these processes, results in complications. This review focuses on different stages atherosclerosis development, ranging from endothelial dysfunction to plaque rupture. In addition, post-transcriptional regulation modulation microRNAs lncRNAs, role microbiota, importance sex as crucial are covered here order provide global view disease.

Язык: Английский

Процитировано

562

The novel regulatory role of lncRNA‐miRNAmRNA axis in cardiovascular diseases DOI Creative Commons
Ying Huang

Journal of Cellular and Molecular Medicine, Год журнала: 2018, Номер 22(12), С. 5768 - 5775

Опубликована: Сен. 6, 2018

Long noncoding RNAs (lncRNAs) are longer than 200 nt in length that characterized by low levels of sequence conservation and expression; lncRNAs modulate various biological functions at epigenetic, transcriptional post-transcriptional levels, or directly regulate protein activity. As a family small evolutionarily conserved RNAs, microRNAs (miRNAs) capable regulating physiological pathological processes via inhibiting target mRNA translation promoting degradation. A number studies have confirmed both miRNAs closely associated with the development cardiovascular diseases (CVDs), such as cardiac remodelling, heart failure, myocardial injury arrhythmia, they act biomarkers, potential therapeutic targets strong indicators prognosis; however, underlying molecular mechanism has not been elucidated. Recently, emerging evidence showed novel regulatory crosstalk among lncRNAs, mRNAs plays pivotal role pathophysiological CVDs response to stress stimuli. In this review, I comprehensively summarized relationship highlighted important lncRNA-miRNA-mRNA axis CVDs.

Язык: Английский

Процитировано

399

Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction DOI Creative Commons
Chang Liu, Mudi Yao, Chaopeng Li

и другие.

Theranostics, Год журнала: 2017, Номер 7(11), С. 2863 - 2877

Опубликована: Янв. 1, 2017

Vascular dysfunction is a hallmark of ischemic, cancer, and inflammatory diseases, contributing to disease progression. Circular RNAs (circRNAs) are endogenous non-coding RNAs, which have been reported be abnormally expressed in many human diseases. In this study, we used retinal vasculature determine the role circular RNA vascular dysfunction. We revealed that cZNF609 was significantly up-regulated upon high glucose hypoxia stress vivo vitro. silencing decreased vessel loss suppressed pathological angiogenesis vivo. increased endothelial cell migration tube formation, protected against oxidative By contrast, transgenic overexpression showed an opposite effects. acted as miR-615-5p sponge sequester inhibit activity, led MEF2A expression. could rescue silencing-mediated effects on migration, apoptosis. Moreover, dysregulated expression detected clinical samples patients with diabetes, hypertension, coronary artery disease. Intervention promising therapy for

Язык: Английский

Процитировано

247

H19 knockdown suppresses proliferation and induces apoptosis by regulating miR-148b/WNT/β-catenin in ox-LDL -stimulated vascular smooth muscle cells DOI Creative Commons
Lei Zhang, Hailing Cheng,

Yuxia Yue

и другие.

Journal of Biomedical Science, Год журнала: 2018, Номер 25(1)

Опубликована: Фев. 7, 2018

Long non-coding RNAs (lncRNAs) have been identified as critical regulators in the development of atherosclerosis (AS). Here, we focused on discussing roles and molecular mechanisms lncRNA H19 vascular smooth muscle cells (VSMCs) progression.RT-qPCR assay was used to detect expression patterns miR-148b clinical samples cells. Cell proliferative ability evaluated by CCK-8 colony formation assays. apoptotic capacity assessed cell percentage caspase-3 activity. Bioinformatics analysis, luciferase RNA immunoprecipitation (RIP) assays were employed demonstrate relationship among H19, wnt family member 1 (WNT1). Western blot performed determine expressions proliferating nuclear antigen (PCNA), ki-67, Bax, Bcl-2, WNT1, β-catenin, C-myc E-cadherin.The level increased decreased human AS patient serums oxidized low-density lipoprotein (ox-LDL)-stimulated aorta (HA-VSMCs). knockdown suppressed proliferation promoted apoptosis HA-VSMCs following treatment ox-LDL. inhibited direct interaction. Moreover, inhibitor could reverse effects depletion ox-LDL-stimulated HA-VSMCs. Further mechanical explorations showed that WNT1 a target acted competing endogenous (ceRNA) enhance expression. Furthermore, miR-148 exerted its pro-proliferation anti-apoptosis through activating WNT/β-catenin signaling HA-VSMCs.H19 facilitated modulating pathway via HA-VSMCs, implicating potential values therapy.

Язык: Английский

Процитировано

179

Angio-LncRs: LncRNAs that regulate angiogenesis and vascular disease DOI Creative Commons
Bo Yu, Shusheng Wang

Theranostics, Год журнала: 2018, Номер 8(13), С. 3654 - 3675

Опубликована: Янв. 1, 2018

Long noncoding RNAs (lncRNAs) represent a large subgroup of that are longer than 200 nucleotides and have no apparent protein coding potential.They diverse functions in different biological processes by regulating chromatin remodeling or translation.This review summarizes the recent progress lncRNAs angiogenesis vascular diseases.A general overview lncRNA functional mechanisms will be introduced.A list lncRNAs, which termed "Angio-LncRs", including MALAT1, MANTIS, PUNISHER, MEG3, MIAT, SENCR GATA6-AS, discussed regarding their expression, regulation, function mechanism action angiogenesis.Implications diseases, such as atherosclerosis, hypertension, retinopathies tumor also discussed.

Язык: Английский

Процитировано

175

Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes DOI Creative Commons
Sathishkumar Chandrakumar, Prabu Paramasivam, Viswanathan Mohan

и другие.

Human Genomics, Год журнала: 2018, Номер 12(1)

Опубликована: Авг. 23, 2018

Studying epigenetics is expected to provide precious information on how environmental factors contribute type 2 diabetes mellitus (T2DM) at the genomic level. With progress of whole-genome resequencing efforts, it now known that 75-90% human genome was transcribed generate a series long non-coding RNAs (lncRNAs). While lncRNAs are gaining widespread attention as potential and robust biomarkers in genesis well progression several disease states, their clinical relevance regulatory mechanisms yet be explored field metabolic disorders including diabetes. Despite fact Asian Indians highly insulin resistant more prone develop T2DM associated vascular complications, there virtually lack data role setting. Therefore, we sought evaluate panel senescence-inflammation signatures peripheral blood mononuclear cells (PBMCs) from patients with (T2DM; n = 30) compared individuals normal glucose tolerance (NGT; 32).Compared control subjects, expression levels PBMCs showed significantly (p < 0.05) increased HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, NBR2. In contrast, lncRNA patterns THRIL SALRNA1 were decreased subjects. At transcriptional level, senescence markers (p53, p21, p16, β-galactosidase), proinflammatory (TNF-α, IL6, MCP1, IL1-β), epigenetic signature histone deacetylase-3 (HDAC3) elevated Interestingly, mRNA Sirt1 telomere length Majority altered positively correlated poor glycemic control, resistance, senescence, inflammation, HDAC3 negatively length. Logistic regression analysis revealed significant association T2DM, but this lost after adjusting for resistance (HOMA-IR) markers.Our study provides clinically relevant evidence accelerated cellular inflammation.

Язык: Английский

Процитировано

165

Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes DOI Open Access
Evgeni Gusev, Alexey Sarapultsev

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 7910 - 7910

Опубликована: Апрель 26, 2023

Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from general pathology perspective, particularly with regard atherogenesis patterns in context both canonical and non-classical inflammation types. In review, we analyze various typical phenomena outcomes cellular pro-inflammatory stress atherosclerosis, as well role endothelial dysfunction local systemic manifestations low-grade inflammation. We also present features immune development productive stable unstable plaques, along their similarities differences compared There are numerous factors that act inducers inflammatory process including vascular endothelium aging, metabolic dysfunctions, autoimmune, some cases, infectious damage factors. Life-critical complications such cardiogenic shock severe strokes, associated acute hyperinflammation. Additionally, critical atherosclerotic ischemia lower extremities induces paracoagulation chronic Conversely, sepsis, other conditions, diseases contribute atherogenesis. summary, can be characterized an independent form inflammation, sharing but having fundamental variants (classic vasculitis).

Язык: Английский

Процитировано

129

LncRNAs in vascular biology and disease DOI
Viorel Simion, Stefan Haemmig, Mark W. Feinberg

и другие.

Vascular Pharmacology, Год журнала: 2018, Номер 114, С. 145 - 156

Опубликована: Фев. 6, 2018

Язык: Английский

Процитировано

158

LncRNAs: From Basic Research to Medical Application DOI Creative Commons
Tao Wu,

Yantao Du

International Journal of Biological Sciences, Год журнала: 2017, Номер 13(3), С. 295 - 307

Опубликована: Янв. 1, 2017

This review aimed to summarize the current research contents about long noncoding RNAs (lncRNAs) and some related lncRNAs as molecular biomarkers or therapy strategies in human cancer cardiovascular diseases.Following development of various kinds sequencing technologies, have become one most unknown areas that need be explored.First, definition classification were constantly amended supplemented because their complexity diversity.Second, several methods been developed study characteristic lncRNAs, including new species identifications, subcellular localization, gain loss function, interaction, bioinformatics analysis.Third, based on present results from basic researches, working mechanisms proved different forms interactions involving DNAs, RNAs, proteins.Fourth, lncRNA can play important roles during embryogenesis organ differentiations.Finally, tissue-specific expression they could used targets effectively applied diseases, such diseases.

Язык: Английский

Процитировано

122

The lncRNA PDIA3P Interacts with miR-185-5p to Modulate Oral Squamous Cell Carcinoma Progression by Targeting Cyclin D2 DOI Creative Commons
Cheng‐Cao Sun, Ling Zhang, Guang Li

и другие.

Molecular Therapy — Nucleic Acids, Год журнала: 2017, Номер 9, С. 100 - 110

Опубликована: Сен. 22, 2017

Язык: Английский

Процитировано

120