Photothermal
therapy
(PTT)
is
a
promising
approach
for
cancer
targeting
therapy.
However,
the
temperature-dependent
killing
of
tumor
cells
in
PTT
remains
unclear.
In
this
study,
we
report
necroptosis
plays
role
anti-tumor
effects
observed
gold
nanorod
(GNR)-mediated
melanoma.
We
first
synthesized
nanorods
with
adaptor
FA
(GNRs-FA),
which
achieved
high
efficacy
targeted
delivery
to
melanoma
cells.
further
demonstrated
PTT,
precipitated
by
GNRs-FA
under
induction
near-infrared
laser,
was
temperature-dependent.
Furthermore,
photothermal
showed
different
patterns
cell
death
depending
on
varying
temperature
PTT.
lower
at
43
°C,
percentages
apoptosis,
and
necrosis
were
10.2%,
18.3%,
17.6%,
respectively,
suggesting
ineffective
temperatures.
When
increased
49
pattern
switched
dominant
(52.8%).
Interestingly,
when
moderate
46
significantly
(35.1%).
Additionally,
GNRs-FA/PPT-mediated
regulated
RIPK1
pathway.
Taken
together,
study
demonstrate
that
an
important
mechanism
inducing
GNR-mediated
addition
apoptosis
necrosis.
Cell Death and Disease,
Год журнала:
2023,
Номер
14(10)
Опубликована: Окт. 4, 2023
Abstract
Autophagy
is
the
process
by
which
cells
degrade
and
recycle
proteins
organelles
to
maintain
intracellular
homeostasis.
Generally,
autophagy
plays
a
protective
role
in
cells,
but
disruption
of
mechanisms
or
excessive
autophagic
flux
usually
leads
cell
death.
Despite
recent
progress
study
regulation
underlying
molecular
autophagy,
numerous
questions
remain
be
answered.
How
does
regulate
death?
What
are
fine-tuned
regulatory
autophagy-dependent
death
(ADCD)
autophagy-mediated
(AMCD)?
In
this
article,
we
highlight
different
roles
discuss
six
main
autophagy-related
modalities,
with
focus
on
metabolic
changes
caused
endoplasmic
reticulum-phagy
(ER-phagy)-induced
mitophagy
ferroptosis.
Finally,
enhancement
treatment
diseases
offer
new
perspective
based
use
for
functional
conversions
(including
conversion
that
modalities)
clinical
tumors.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2021,
Номер
2021(1)
Опубликована: Янв. 1, 2021
Reactive
oxygen
species
(ROS)
are
essential
for
cellular
signaling
and
response
to
stress.
The
level
of
ROS
the
type
determine
ability
cells
undergo
cell
death.
Furthermore,
dysregulation
antioxidant
pathways
is
associated
with
many
diseases.
It
has
become
apparent
that
death
can
occur
through
different
mechanisms
leading
classifications
types
such
as
apoptosis,
ferroptosis,
necroptosis.
play
roles
in
all
forms
death,
but
it
only
now
coming
into
focus
control
occurs
any
given
cell.
Indeed,
may
act
a
rheostat
allowing
be
engaged
crosstalk
types.
In
this
review,
we
will
describe
regulatory
how
they
under
normal
disease
states.
We
also
propose
could
provide
mechanism
between
determining
Photothermal
therapy
(PTT)
is
a
promising
approach
for
cancer
targeting
therapy.
However,
the
temperature-dependent
killing
of
tumor
cells
in
PTT
remains
unclear.
In
this
study,
we
report
necroptosis
plays
role
anti-tumor
effects
observed
gold
nanorod
(GNR)-mediated
melanoma.
We
first
synthesized
nanorods
with
adaptor
FA
(GNRs-FA),
which
achieved
high
efficacy
targeted
delivery
to
melanoma
cells.
further
demonstrated
PTT,
precipitated
by
GNRs-FA
under
induction
near-infrared
laser,
was
temperature-dependent.
Furthermore,
photothermal
showed
different
patterns
cell
death
depending
on
varying
temperature
PTT.
lower
at
43
°C,
percentages
apoptosis,
and
necrosis
were
10.2%,
18.3%,
17.6%,
respectively,
suggesting
ineffective
temperatures.
When
increased
49
pattern
switched
dominant
(52.8%).
Interestingly,
when
moderate
46
significantly
(35.1%).
Additionally,
GNRs-FA/PPT-mediated
regulated
RIPK1
pathway.
Taken
together,
study
demonstrate
that
an
important
mechanism
inducing
GNR-mediated
addition
apoptosis
necrosis.
