Circadian rhythms and disorders of the timing of sleep

The Lancet, Год журнала: 2022, Номер 400(10357), С. 1061 - 1078

Опубликована: Сен. 1, 2022

Язык: Английский

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Sleep, circadian rhythms and health

Interface Focus, Год журнала: 2020, Номер 10(3), С. 20190098 - 20190098

Опубликована: Апрель 17, 2020

At the core of human thought, for majority individuals in developed nations at least, there is tacit assumption that as a species we are unfettered by demands imposed our biology and can do what want, whatever time choose, whereas reality every aspect physiology behaviour constrained 24 h beat arising from deep within evolution. Our daily circadian rhythms sleep/wake cycle allow us to function optimally dynamic world, adjusting day/night cycle. The themes this review focus upon growing realization ignore sleep systems peril, paper considers mechanisms generate regulate systems; happens mechanistically when these collapse result societal pressures disease; how disruption stress linked; why mental illness invariably occur together; employers attempt mitigate some problems associated with working against internal temporal biology. While health costs be reduced, short-term will always significant negative consequences shift work loss. With mind, society needs address issue decide justified workplace.

Язык: Английский

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Validation of the Sleep Regularity Index in Older Adults and Associations with Cardiometabolic Risk

Scientific Reports, Год журнала: 2018, Номер 8(1)

Опубликована: Сен. 17, 2018

Abstract Sleep disturbances, including insufficient sleep duration and circadian misalignment, confer risk for cardiometabolic disease. Less is known about the association between regularity of sleep/wake schedules risk. This study evaluated external validity a new metric, Regularity Index (SRI), among older adults (n = 1978; mean age 68.7 ± 9.2), as well relationships SRI using data from Multi-Ethnic Study Atherosclerosis (MESA). Results indicated that irregularity was associated with delayed timing, increased daytime sleepiness, reduced light exposure, but independent duration. Greater also correlated 10-year cardiovascular disease greater obesity, hypertension, fasting glucose, hemoglobin A1C, diabetes status. Finally, perceived stress depression, psychiatric factors integrally tied to These results suggest useful measure in adults. Additionally, may represent target early identification prevention Future studies clarify causal direction these effects, mechanisms underlying links risk, utility interventions reducing

Язык: Английский

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Cross-sectional and Prospective Associations of Actigraphy-Assessed Sleep Regularity With Metabolic Abnormalities: The Multi-Ethnic Study of Atherosclerosis

Diabetes Care, Год журнала: 2019, Номер 42(8), С. 1422 - 1429

Опубликована: Июнь 5, 2019

To cross-sectionally and prospectively investigate the association between irregular sleep patterns, a potential marker for circadian disruption, metabolic abnormalities.In Multi-Ethnic Study of Atherosclerosis, participants completed 7-day actigraphy at exam 5 (2010-2013) were followed throughout 6 (2016 to 2017). Sleep regularity was quantified by SD actigraphy-assessed duration onset timing. Metabolic abnormalities defined 1) National Cholesterol Education Program Adult Treatment Panel III criteria 2) data-driven clustering factors.In cross-sectional analysis adjusted sociodemographic lifestyle factors (n = 2,003), every 1-h increase in associated with 27% (95% CI 1.10, 1.47) higher odds syndrome, timing 23% 1.06, 1.42) odds. The associations remained significant additional adjustment sleep-related including duration. In prospective 970), corresponding fully ratio (OR) 1.27 0.97, 1.65) 1.36 (1.03, 1.80) Compared cluster few changes, variability almost doubled characterized incidence multiple (OR 1.97 [95% 1.18, 3.30] OR 2.10 1.25, 3.53] timing).Increased prevalence even after consideration other factors.

Язык: Английский

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COVID-19-mandated social restrictions unveil the impact of social time pressure on sleep and body clock

Scientific Reports, Год журнала: 2020, Номер 10(1)

Опубликована: Дек. 17, 2020

Abstract In humans, sleep regulation is tightly linked to social times that assign local time events, such as school, work, or meals. The impact of these times, collectively—social pressure, on has been studied epidemiologically via quantification the discrepancy between workdays and those work-free days. This known jetlag (SJL). COVID-19-mandated restrictions (SR) constituted a global intervention by affecting worldwide. We launched Global Chrono Corona Survey (GCCS) queried sleep–wake before during SR ( preSR inSR ). 11,431 adults from 40 countries responded April 4 May 6, 2020. final sample consisted 7517 respondents (68.2% females), who had 32.7 ± 9.1 (mean sd) days under SR. led robust changes: mid-sleep free was delayed 50 22 min, respectively; duration increased 26 min but shortened 9 days; SJL decreased ~ 30 min. On , in most people approached their Changes correlated with -use alarm clocks were larger young adults. data indicate massive deficit pre-pandemic provide insights actual need different age-groups suggest tolerable about 20 Relaxed pressure promotes more sleep, smaller reduced use clocks.

Язык: Английский

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