Antioxidants,
Год журнала:
2020,
Номер
9(5), С. 383 - 383
Опубликована: Май 5, 2020
Selenium
is
a
vital
trace
element
present
as
selenocysteine
(Sec)
in
proteins
that
are,
thus,
known
selenoproteins.
Humans
have
25
selenoproteins,
most
of
which
are
functionally
characterized
oxidoreductases,
where
the
Sec
residue
plays
catalytic
role
redox
regulation
and
antioxidant
activity.
Glutathione
peroxidase
pivotal
scavenging
inactivating
hydrogen
lipid
peroxides,
whereas
thioredoxin
reductase
reduces
oxidized
thioredoxins
well
non-disulfide
substrates,
such
hydroperoxides
peroxide.
Selenoprotein
R
protects
cell
against
oxidative
damage
by
reducing
methionine-R-sulfoxide
back
to
methionine.
O
regulates
homeostasis
with
activity
protein
AMPylation.
Moreover,
endoplasmic
reticulum
(ER)
membrane
selenoproteins
(SelI,
K,
N,
S,
Sel15)
involved
ER
stress
regulation.
Selenoproteins
containing
CXXU
motif
(SelH,
M,
T,
V,
W)
putative
oxidoreductases
participate
various
cellular
processes
depending
on
Herein,
we
review
recent
studies
their
physiological
functions
humans,
diseases.
动物学研究,
Год журнала:
2020,
Номер
41(3), С. 220 - 230
Опубликована: Янв. 1, 2020
Ischemia/reperfusion
(I/R)
is
a
pathological
process
that
occurs
in
numerous
organs
throughout
the
human
body,
and
it
frequently
associated
with
severe
cellular
damage
death.
Recently
has
emerged
ferroptosis,
new
form
of
regulated
cell
death
caused
by
iron-dependent
lipid
peroxidation,
plays
significantly
detrimental
role
many
I/R
models.
In
this
review,
we
aim
to
revise
then
explore
molecular
pathogenesis
ferroptosis.
Furthermore,
evaluate
ferroptosis
I/R,
providing
evidence
support
targeting
pathway
may
present
as
therapeutic
intervention
alleviate
ischemia/reperfusion
injury
(IRI)
Cell Death Discovery,
Год журнала:
2021,
Номер
7(1)
Опубликована: Окт. 5, 2021
Abstract
Characterized
by
excessive
iron
accumulation
and
lipid
peroxidation,
ferroptosis
is
a
novel
form
of
iron-dependent
cell
death,
which
morphologically,
genetically,
biochemically
distinct
from
other
well-known
death.
In
recent
years,
has
been
quickly
gaining
attention
in
the
field
liver
diseases,
as
predisposed
to
oxidative
injury
generally,
primary
characteristic
most
major
diseases.
current
review,
we
first
delineate
three
cellular
defense
mechanisms
against
(GPx4
mitochondria
cytosol,
FSP1
on
plasma
membrane,
DHODH
mitochondria),
along
with
four
canonical
modulators
(system
Xc
−
,
nuclear
factor
erythroid
2-related
2,
p53,
GTP
cyclohydrolase-1).
Next,
review
progress
studies
delineating
molecular
underlying
pathophysiology
several
common
diseases
including
ischemia/reperfusion-related
(IRI),
nonalcoholic
fatty
disease
(NAFLD),
alcoholic
(ALD),
hemochromatosis
(HH),
drug-induced
(DILI),
hepatocellular
carcinoma
(HCC).
Furthermore,
also
highlight
both
challenges
promises
that
emerged
should
be
addressed
pursued
future
investigations
before
regulation
could
adopted
an
effective
therapeutic
target
clinical
practice.
Pharmacology & Therapeutics,
Год журнала:
2023,
Номер
244, С. 108373 - 108373
Опубликована: Март 8, 2023
Ferroptosis
is
a
type
of
regulated
cell
death
characterized
by
intracellular
accumulation
iron
and
reactive
oxygen
species,
inhibition
system
Xc-,
glutathione
depletion,
nicotinamide
adenine
dinucleotide
phosphate
oxidation
lipid
peroxidation.
Since
its
discovery
characterization
in
2012,
many
efforts
have
been
made
to
reveal
the
underlying
mechanisms,
modulating
compounds,
involvement
disease
pathways.
inducers
include
erastin,
sorafenib,
sulfasalazine
glutamate,
which,
inhibiting
prevent
import
cysteine
into
cells.
RSL3,
statins,
Ml162
Ml210
induce
ferroptosis
peroxidase
4
(GPX4),
which
responsible
for
preventing
formation
peroxides,
FIN56
withaferin
trigger
GPX4
degradation.
On
other
side,
inhibitors
ferrostatin-1,
liproxstatin-1,
α-tocopherol,
zileuton,
FSP1,
CoQ10
BH4,
interrupt
peroxidation
cascade.
Additionally,
deferoxamine,
deferiprone
N-acetylcysteine,
targeting
cellular
pathways,
also
classified
as
inhibitors.
Increased
evidence
has
established
distinct
brain
diseases,
including
Alzheimer's,
Parkinson's
Huntington's
amyotrophic
lateral
sclerosis,
multiple
Friedreich's
ataxia.
Thus,
deep
understanding
how
contributes
these
it
can
be
modulated,
open
new
window
opportunities
novel
therapeutic
strategies
targets.
Other
studies
shown
sensitivity
cancer
cells
with
mutated
RAS
induction
that
chemotherapeutic
agents
synergize
tumor
treatment.
tempting
consider
may
arise
target
mechanistic
pathway
treatment
tumors.
Therefore,
this
work
provides
an
up-to-date
review
on
molecular
mechanisms
their
diseases.
In
addition,
information
main
targets
provided.
Antioxidants,
Год журнала:
2020,
Номер
9(5), С. 383 - 383
Опубликована: Май 5, 2020
Selenium
is
a
vital
trace
element
present
as
selenocysteine
(Sec)
in
proteins
that
are,
thus,
known
selenoproteins.
Humans
have
25
selenoproteins,
most
of
which
are
functionally
characterized
oxidoreductases,
where
the
Sec
residue
plays
catalytic
role
redox
regulation
and
antioxidant
activity.
Glutathione
peroxidase
pivotal
scavenging
inactivating
hydrogen
lipid
peroxides,
whereas
thioredoxin
reductase
reduces
oxidized
thioredoxins
well
non-disulfide
substrates,
such
hydroperoxides
peroxide.
Selenoprotein
R
protects
cell
against
oxidative
damage
by
reducing
methionine-R-sulfoxide
back
to
methionine.
O
regulates
homeostasis
with
activity
protein
AMPylation.
Moreover,
endoplasmic
reticulum
(ER)
membrane
selenoproteins
(SelI,
K,
N,
S,
Sel15)
involved
ER
stress
regulation.
Selenoproteins
containing
CXXU
motif
(SelH,
M,
T,
V,
W)
putative
oxidoreductases
participate
various
cellular
processes
depending
on
Herein,
we
review
recent
studies
their
physiological
functions
humans,
diseases.
