Human Reproduction Update,
Год журнала:
2013,
Номер
20(2), С. 293 - 307
Опубликована: Окт. 16, 2013
Research
within
the
last
decade
has
shown
melatonin
to
have
previously-unsuspected
beneficial
actions
on
peripheral
reproductive
organs.
Likewise,
numerous
investigations
documented
that
stable
circadian
rhythms
are
also
helpful
in
maintaining
health.
The
relationship
of
and
rhythmicity
maternal
fetal
health
is
summarized
this
review.
Databases
were
searched
for
related
published
English
literature
up
15
May
2013.
search
terms
used
various
combinations
included
melatonin,
rhythms,
biological
clock,
suprachiasmatic
nucleus,
ovary,
pregnancy,
uterus,
placenta,
fetus,
pre-eclampsia,
intrauterine
growth
restriction,
ischemia-reperfusion,
chronodisruption,
antioxidants,
oxidative
stress
free
radicals.
results
studies
uncovered
herein.
Both
impact
reproduction,
especially
during
pregnancy.
Melatonin
a
multifaceted
molecule
with
direct
radical
scavenging
indirect
antioxidant
activities.
produced
both
ovary
placenta
where
it
protects
against
molecular
mutilation
cellular
dysfunction
arising
from
oxidative/nitrosative
stress.
particular,
often
site
excessive
generation
due
less
than
optimal
adhesion
uterine
wall,
which
leads
either
persistent
hypoxia
or
intermittent
reoxygenation,
processes
cause
massive
organ
dysfunction.
This
may
contribute
pre-eclampsia
other
disorders
complicate
ameliorated
damage
fetus
experiments
using
non-human
mammals.
maintenance
regular
light/dark
sleep/wake
cycle
important
stabilize
generated
by
central
pacemaker,
nuclei.
Optimal
mother
since
her
directly
indirectly
via
rhythm,
programs
developing
master
oscillator
fetus.
Experimental
disturbed
referred
as
perturbed
cycles
negative
consequences
maturing
oscillators,
lead
psychological
behavioral
problems
newborn.
To
optimize
prevent
disturbances
shift
work
bright
light
exposure
at
night
should
be
avoided,
trimester
Finally,
synergizes
oxytocin
promote
delivery
Since
blood
levels
normally
highest
dark
period,
propensity
childbirth
occur
relate
high
time
concert
enhance
strength
contractions.
A
number
conclusions
naturally
evolve
data
review:
(i)
pineal
placental
origin,
essential
functions
maturation
placenta/uterine
homeostasis;
(ii)
clock
genes,
components
all
cells
including
those
organs,
roles
organismal
(fetal
maternal)
physiology;
(iii)
potent
coupled
its
virtual
absence
toxicity,
indoleamine
utility
treatment
ischemia/reperfusion,
etc.
(iv)
parturition
synergism
between
nocturnal
increase
oxytocin.
Antioxidants and Redox Signaling,
Год журнала:
2015,
Номер
23(9), С. 734 - 746
Опубликована: Апрель 19, 2015
Significance:
The
redox
code
is
a
set
of
principles
that
defines
the
positioning
nicotinamide
adenine
dinucleotide
(NAD,
NADP)
and
thiol/disulfide
other
systems
as
well
thiol
proteome
in
space
time
biological
systems.
richly
elaborated
an
oxygen-dependent
life,
where
activation/deactivation
cycles
involving
O2
H2O2
contribute
to
spatiotemporal
organization
for
differentiation,
development,
adaptation
environment.
Disruption
this
organizational
structure
during
oxidative
stress
represents
fundamental
mechanism
system
failure
disease.
Recent
Advances:
Methodology
assessing
components
under
physiological
conditions
has
progressed,
permitting
insight
into
allowing
identification
partners
proteomics
metabolomics.
Critical
Issues:
Complexity
networks
regulation
being
revealed
step
by
step,
yet
much
still
needs
be
learned.
Future
Directions:
Detailed
knowledge
molecular
patterns
generated
from
defined
or
pathological
cells
organs
will
understanding
component
health
Ultimately,
there
scientific
basis
modern
medicine.
Antioxid.
Redox
Signal.
23,
734–746.
Diabetes,
Год журнала:
2014,
Номер
63(6), С. 1860 - 1869
Опубликована: Янв. 24, 2014
Shift
workers,
who
are
exposed
to
irregular
sleep
schedules
resulting
in
deprivation
and
misalignment
of
circadian
rhythms,
have
an
increased
risk
diabetes
relative
day
workers.
In
healthy
adults,
restriction
without
promotes
insulin
resistance.
To
determine
whether
the
rhythms
that
typically
occurs
shift
work
involves
intrinsic
adverse
metabolic
effects
independently
loss,
a
parallel
group
design
was
used
study
26
adults.
Both
interventions
involved
3
inpatient
days
with
10-h
bedtimes,
followed
by
8
5
h
fixed
nocturnal
bedtimes
(circadian
alignment)
or
delayed
8.5
on
4
misalignment).
Daily
total
time
(SD)
during
intervention
nearly
identical
aligned
misaligned
conditions
(4
48
min
[5
min]
vs.
45
[6
min]).
both
groups,
sensitivity
(SI)
significantly
decreased
after
restriction,
compensatory
increase
secretion,
inflammation
increased.
male
participants
misalignment,
reduction
SI
doubled
compared
those
maintained
regular
bedtimes.
Circadian
may
inflammation,
loss.
Proceedings of the National Academy of Sciences,
Год журнала:
2013,
Номер
110(12)
Опубликована: Фев. 25, 2013
Significance
Insufficient
sleep
and
circadian
rhythm
disruption
are
associated
with
negative
health
outcomes,
but
the
mechanisms
involved
remain
largely
unexplored.
We
show
that
one
wk
of
insufficient
alters
gene
expression
in
human
blood
cells,
reduces
amplitude
rhythms
expression,
intensifies
effects
subsequent
acute
total
loss
on
expression.
The
affected
genes
chromatin
remodeling,
regulation
immune
stress
responses.
data
imply
molecular
mediating
highlight
interrelationships
between
homeostasis,
rhythmicity,
metabolism.
International Review of Psychiatry,
Год журнала:
2014,
Номер
26(2), С. 139 - 154
Опубликована: Апрель 1, 2014
Circadian
rhythms
are
near
24-h
patterns
of
physiology
and
behaviour
that
present
independent
external
cues
including
hormones,
body
temperature,
mood,
sleep
propensity.
The
term
'circadian
misalignment'
describes
a
variety
circumstances,
such
as
inappropriately
timed
wake,
misalignment
sleep/wake
with
feeding
rhythms,
or
misaligned
central
peripheral
rhythms.
predominance
early
research
focused
on
to
the
biological
night.
However,
discovery
clock
genes
presence
circadian
oscillators
have
expanded
definitions
misalignment.
Experimental
studies
conducted
in
animal
models
humans
provided
evidence
potential
mechanisms
link
negative
outcomes.
These
include
dysregulation
behaviours,
changes
appetite
stimulating
glucose
metabolism
mood.
This
review
has
two
foci:
(1)
describe
how
been
defined
evaluated
laboratory
field
experiments,
(2)
linking
different
types
increased
risk
for
physical
(cardiovascular
disease,
diabetes,
obesity,
cancer)
psychiatric
(depression,
bipolar,
schizophrenia,
attention
deficit)
disorders.
will
role
factor
disease
general
population
clinical
populations,
rhythm
disorders
