Science Immunology,
Год журнала:
2018,
Номер
3(26)
Опубликована: Авг. 3, 2018
The
death
of
a
cell
is
an
inevitable
part
its
biology.
During
homeostasis,
most
cells
die
through
apoptosis.
If
homeostasis
disturbed,
can
switch
to
proinflammatory
forms
death,
such
as
necroptosis,
pyroptosis,
or
NETosis.
We
demonstrate
that
the
formation
neutrophil
extracellular
traps
(NETs),
special
form
releases
chromatin
structures
space,
dependent
on
gasdermin
D
(GSDMD).
GSDMD
pore-forming
protein
and
executor
pyroptosis.
screened
chemical
library
found
small
molecule
based
pyrazolo-oxazepine
scaffold
efficiently
blocks
NET
GSDMD-mediated
pyroptotic
in
human
cells.
NETosis,
proteolytically
activated
by
proteases
and,
turn,
affects
protease
activation
nuclear
expansion
feed-forward
loop.
In
addition
central
role
we
propose
also
plays
essential
function
Cell Death and Differentiation,
Год журнала:
2018,
Номер
25(3), С. 486 - 541
Опубликована: Янв. 23, 2018
Over
the
past
decade,
Nomenclature
Committee
on
Cell
Death
(NCCD)
has
formulated
guidelines
for
definition
and
interpretation
of
cell
death
from
morphological,
biochemical,
functional
perspectives.
Since
field
continues
to
expand
novel
mechanisms
that
orchestrate
multiple
pathways
are
unveiled,
we
propose
an
updated
classification
subroutines
focusing
mechanistic
essential
(as
opposed
correlative
dispensable)
aspects
process.
As
provide
molecularly
oriented
definitions
terms
including
intrinsic
apoptosis,
extrinsic
mitochondrial
permeability
transition
(MPT)-driven
necrosis,
necroptosis,
ferroptosis,
pyroptosis,
parthanatos,
entotic
death,
NETotic
lysosome-dependent
autophagy-dependent
immunogenic
cellular
senescence,
mitotic
catastrophe,
discuss
utility
neologisms
refer
highly
specialized
instances
these
processes.
The
mission
NCCD
is
a
widely
accepted
nomenclature
in
support
continued
development
field.
Signal Transduction and Targeted Therapy,
Год журнала:
2021,
Номер
6(1)
Опубликована: Март 29, 2021
Abstract
Currently,
pyroptosis
has
received
more
and
attention
because
of
its
association
with
innate
immunity
disease.
The
research
scope
expanded
the
discovery
gasdermin
family.
A
great
deal
evidence
shows
that
can
affect
development
tumors.
relationship
between
tumors
is
diverse
in
different
tissues
genetic
backgrounds.
In
this
review,
we
provide
basic
knowledge
pyroptosis,
explain
tumors,
focus
on
significance
tumor
treatment.
addition,
further
summarize
possibility
as
a
potential
treatment
strategy
describe
side
effects
radiotherapy
chemotherapy
caused
by
pyroptosis.
brief,
double-edged
sword
for
rational
use
dual
effect
will
help
us
explore
formation
ideas
patients
to
develop
new
drugs
based
Immunological Reviews,
Год журнала:
2017,
Номер
277(1), С. 61 - 75
Опубликована: Апрель 30, 2017
Summary
Cell
death
is
a
fundamental
biological
phenomenon
that
essential
for
the
survival
and
development
of
an
organism.
Emerging
evidence
also
indicates
cell
contributes
to
immune
defense
against
infectious
diseases.
Pyroptosis
form
inflammatory
programmed
pathway
activated
by
human
mouse
caspase‐1,
caspase‐4
caspase‐5,
or
caspase‐11.
These
caspases
are
used
host
control
bacterial,
viral,
fungal,
protozoan
pathogens.
requires
cleavage
activation
pore‐forming
effector
protein
gasdermin
D
caspases.
Physical
rupture
causes
release
pro‐inflammatory
cytokines
IL
‐1β
‐18,
alarmins
endogenous
danger‐associated
molecular
patterns,
signifying
potential
pyroptosis.
Here,
we
describe
central
role
pyroptosis
in
mediating
immunity
infection
clearance
Cytotoxic
lymphocyte-mediated
immunity
relies
on
granzymes.
Granzymes
are
thought
to
kill
target
cells
by
inducing
apoptosis,
although
the
underlying
mechanisms
not
fully
understood.
Here,
we
report
that
natural
killer
and
cytotoxic
T
lymphocytes
gasdermin
B
(GSDMB)-positive
through
pyroptosis,
a
form
of
proinflammatory
cell
death
executed
family
pore-forming
proteins.
Killing
results
from
cleavage
GSDMB
lymphocyte-derived
granzyme
A
(GZMA),
which
unleashes
its
activity.
Interferon-γ
(IFN-γ)
up-regulates
expression
promotes
pyroptosis.
is
highly
expressed
in
certain
tissues,
particularly
digestive
tract
epithelia,
including
derived
tumors.
Introducing
GZMA-cleavable
into
mouse
cancer
tumor
clearance
mice.
This
study
establishes
gasdermin-mediated
pyroptosis
as
lymphocyte-killing
mechanism,
may
enhance
antitumor
immunity.
Journal of Hematology & Oncology,
Год журнала:
2020,
Номер
13(1)
Опубликована: Авг. 10, 2020
Abstract
In
recent
years,
cancer
immunotherapy
based
on
immune
checkpoint
inhibitors
(ICIs)
has
achieved
considerable
success
in
the
clinic.
However,
ICIs
are
significantly
limited
by
fact
that
only
one
third
of
patients
with
most
types
respond
to
these
agents.
The
induction
cell
death
mechanisms
other
than
apoptosis
gradually
emerged
as
a
new
treatment
strategy
because
tumors
harbor
innate
resistance
apoptosis.
date,
possibility
combining
two
modalities
not
been
discussed
systematically.
Recently,
few
studies
revealed
crosstalk
between
distinct
and
antitumor
immunity.
pyroptosis,
ferroptosis,
necroptosis
combined
showed
synergistically
enhanced
activity,
even
ICI-resistant
tumors.
Immunotherapy-activated
CD8+
T
cells
traditionally
believed
induce
tumor
via
following
main
pathways:
(i)
perforin-granzyme
(ii)
Fas-FasL.
identified
mechanism
which
suppress
growth
inducing
ferroptosis
provoked
review
relationship
system
activation.
Hence,
this
review,
we
summarize
knowledge
reciprocal
interaction
immunity
mechanisms,
particularly
necroptosis,
three
potentially
novel
immunogenic
death.
Because
evidence
is
derived
from
using
animal
models,
also
reviewed
related
bioinformatics
data
available
for
human
tissues
public
databases,
partially
confirmed
presence
interactions
activation
