Open Ephys: an open-source, plugin-based platform for multichannel electrophysiology

Journal of Neural Engineering, Год журнала: 2017, Номер 14(4), С. 045003 - 045003

Опубликована: Фев. 7, 2017

Closed-loop experiments, in which causal interventions are conditioned on the state of system under investigation, have become increasingly common neuroscience. Such experiments can a high degree explanatory power, but they require precise implementation that be difficult to replicate across laboratories. We sought overcome this limitation by building open-source software makes it easier develop and share algorithms for closed-loop control.We created Open Ephys GUI, an platform multichannel electrophysiology experiments. In addition standard 'open-loop' visualization recording functionality, GUI also includes modules delivering feedback response events detected incoming data stream. Importantly, these built shared as plugins, possible users extend functionality through simple API, without having understand inner workings entire application.In combination with low-cost, hardware amplifying digitizing neural signals, has been used perturb hippocampal theta rhythm phase-specific manner.The is first widely application leverages plugin-based workflow. hope will lower barrier entry electrophysiologists who wish incorporate real-time into their research.

Язык: Английский

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Closed-Loop and Activity-Guided Optogenetic Control

Neuron, Год журнала: 2015, Номер 86(1), С. 106 - 139

Опубликована: Апрель 1, 2015

Язык: Английский

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Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2017, Номер 372(1715), С. 20160158 - 20160158

Опубликована: Янв. 17, 2017

We summarize here the results presented and subsequent discussion from meeting on Integrating Hebbian Homeostatic Plasticity at Royal Society in April 2016. first outline major themes meeting. next provide a synopsis of outstanding questions that emerged end finally suggest potential directions research we believe are most promising to develop an understanding how these two forms plasticity interact facilitate functional changes brain.This article is part themed issue 'Integrating homeostatic plasticity'.

Язык: Английский

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Targeting Homeostatic Synaptic Plasticity for Treatment of Mood Disorders

Neuron, Год журнала: 2020, Номер 106(5), С. 715 - 726

Опубликована: Июнь 1, 2020

Язык: Английский

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An Overview of In Vitro Biological Neural Networks for Robot Intelligence

Cyborg and Bionic Systems, Год журнала: 2023, Номер 4

Опубликована: Янв. 1, 2023

In vitro biological neural networks (BNNs) interconnected with robots, so-called BNN-based neurorobotic systems, can interact the external world, so that they present some preliminary intelligent behaviors, including learning, memory, robot control, etc. This work aims to provide a comprehensive overview of behaviors presented by particular focus on those related intelligence. this work, we first introduce necessary background understand 2 characteristics BNNs: nonlinear computing capacity and network plasticity. Then, describe typical architecture systems outline mainstream techniques realize such an from aspects: robots BNNs robots. Next, separate into parts according whether rely solely (computing capacity-dependent) or depend also plasticity (network plasticity-dependent), which are then expounded respectively, realization Finally, development trends challenges discussed.

Язык: Английский

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Keeping Your Brain in Balance: Homeostatic Regulation of Network Function

Annual Review of Neuroscience, Год журнала: 2024, Номер 47(1), С. 41 - 61

Опубликована: Фев. 21, 2024

To perform computations with the efficiency necessary for animal survival, neocortical microcircuits must be capable of reconfiguring in response to experience, while carefully regulating excitatory and inhibitory connectivity maintain stable function. This dynamic fine-tuning is accomplished through a rich array cellular homeostatic plasticity mechanisms that stabilize important network features such as firing rates, information flow, sensory tuning properties. Further, these functional properties can stabilized by different forms plasticity, including target or synapses, regulate intrinsic neuronal excitability. Here we discuss which aspects circuit function are under control, how this homeostasis realized on molecular levels, pathological consequences when impaired. A remaining challenge elucidate diverse cooperate within complex circuits enable them both flexible stable.

Язык: Английский

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Glutamatergic synapses are structurally and biochemically complex because of multiple plasticity processes: long-term potentiation, long-term depression, short-term potentiation and scaling

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2017, Номер 372(1715), С. 20160260 - 20160260

Опубликована: Янв. 17, 2017

Synapses are complex because they perform multiple functions, including at least six mechanistically different forms of plasticity. Here, I comment on recent developments regarding these processes. (i) Short-term potentiation (STP), a Hebbian process that requires small amounts synaptic input, appears to make strong contributions some working memory. (ii) The rules for long-term (LTP) induction in CA3 have been clarified: does not depend obligatorily backpropagating sodium spikes but, rather, dendritic branch-specific N-methyl-d-aspartate (NMDA) spikes. (iii) Late LTP, dopamine signal (and is therefore neoHebbian), mediated by trans-synaptic growth the synapse, occurs about an hour after LTP induction. (iv) LTD processes and include both homosynaptic heterosynaptic forms. (v) Synaptic scaling produced changes activity levels primarily cell-autonomous, but rather network activity. (vi) evidence distance-dependent along primary dendrite firm, plausible structural-based mechanism suggested.Ideas mechanisms function need take into consideration newly emerging data structure. Recent super-resolution studies indicate glutamatergic synapses modular (module size 70-80 nm), as predicted theoretical work. Modules structures high concentrations postsynaptic density-95 (PSD-95) α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. These modules quasi-independent loci AMPA-mediated transmission may be independently modifiable, suggesting new understanding quantal transmission.This article part themed issue 'Integrating homeostatic plasticity.'

Язык: Английский

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Optogenetic feedback control of neural activity

eLife, Год журнала: 2015, Номер 4

Опубликована: Июль 3, 2015

Optogenetic techniques enable precise excitation and inhibition of firing in specified neuronal populations artifact-free recording activity. Several studies have suggested that optical stimulation provides the precision dynamic range requisite for closed-loop control, but no approach yet permits feedback control firing. Here we present ‘optoclamp’, a technology continuous, real-time adjustments bidirectional order to lock spiking activity at targets over timescales ranging from seconds days. We demonstrate how this system can be used decouple levels ongoing changes network excitability due multi-hour periods glutamatergic or GABAergic neurotransmission blockade vitro as well impinging vibrissal sensory drive vivo. This enables disentangle causally related variables circuit activation physiologically ethologically relevant manner.

Язык: Английский

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Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss

Neuron, Год журнала: 2017, Номер 96(4), С. 871 - 882.e5

Опубликована: Ноя. 1, 2017

Язык: Английский

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All for One But Not One for All: Excitatory Synaptic Scaling and Intrinsic Excitability Are Coregulated by CaMKIV, Whereas Inhibitory Synaptic Scaling Is Under Independent Control

Journal of Neuroscience, Год журнала: 2017, Номер 37(28), С. 6778 - 6785

Опубликована: Июнь 7, 2017

Neocortical circuits use a family of homeostatic plasticity mechanisms to stabilize firing, including excitatory and inhibitory synaptic scaling intrinsic (Turrigiano Nelson, 2004). All three can be induced in tandem cultured rat neocortical pyramidal neurons by chronic manipulations but it is unknown whether they are coinduced the same activity-sensors signaling pathways, or under independent control. Calcium/calmodulin-dependent protein kinase type IV (CaMKIV) key sensory/effector that senses perturbations firing through changes calcium influx, translates this into compensatory quantal amplitude (Ibata et al., 2008; Goold Nicoll, 2010). Whether CaMKIV also controls was unknown. To test we manipulated individual using dominant-negative (dn) constitutively-active (ca) forms nuclear-localized measured induction all plasticity. We found were bidirectionally these manipulations. In contrast, cell-autonomous had no impact on amplitude. Finally, spontaneous rates shifted up down dnCaMKIV caCaMKIV, respectively, suggesting uncoupling activation from activity generates an error signal negative feedback mechanism rates. Together, our data show excitability tightly coordinated bidirectional pathway, whereas sensed regulated control mechanism. SIGNIFICANCE STATEMENT Maintaining stable function highly interconnected neural essential for preventing circuit disorders, accomplished set sense compensate activity. These "homeostatic" target excitation, inhibition, excitability, independently controlled not known. find excitation coregulated signaling, which neuronal inhibition unaffected neurons. results stability both regulate some aspects as well circuit-level adjust inhibition.

Язык: Английский

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