Human T Cell Development, Localization, and Function throughout Life

Immunity, Год журнала: 2018, Номер 48(2), С. 202 - 213

Опубликована: Фев. 1, 2018

Язык: Английский

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Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

Cell Reports, Год журнала: 2017, Номер 20(12), С. 2921 - 2934

Опубликована: Сен. 1, 2017

Язык: Английский

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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

European Journal of Immunology, Год журнала: 2019, Номер 49(10), С. 1457 - 1973

Опубликована: Окт. 1, 2019

These guidelines are a consensus work of considerable number members the immunology and flow cytometry community. They provide theory key practical aspects enabling immunologists to avoid common errors that often undermine immunological data. Notably, there comprehensive sections all major immune cell types with helpful Tables detailing phenotypes in murine human cells. The latest techniques applications also described, featuring examples data can be generated and, importantly, how analysed. Furthermore, tips, tricks pitfalls avoid, written peer-reviewed by leading experts field, making this an essential research companion.

Язык: Английский

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Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Nature Medicine, Год журнала: 2018, Номер 24(7), С. 986 - 993

Опубликована: Июнь 22, 2018

Язык: Английский

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Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Nature Communications, Год журнала: 2018, Номер 9(1)

Опубликована: Июль 9, 2018

Abstract Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that CD103 + CD39 tumor-infiltrating CD8 (CD8 TIL) are enriched tumor-reactive both in primary metastatic tumors. This TIL subset is found across six different malignancies displays an exhausted tissue-resident memory phenotype. TILs have a distinct T-cell receptor (TCR) repertoire, with clones expanded the but present at low frequencies periphery. also efficiently kill autologous MHC-class I-dependent manner. Finally, higher of head neck associated better overall survival. Our data thus describe approach detecting will help define mechanisms existing treatments, may lead to future adoptive therapies.

Язык: Английский

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Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

Cell, Год журнала: 2019, Номер 178(6), С. 1493 - 1508.e20

Опубликована: Авг. 29, 2019

Язык: Английский

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CD8+ T cell differentiation and dysfunction in cancer

Nature reviews. Immunology, Год журнала: 2021, Номер 22(4), С. 209 - 223

Опубликована: Июль 12, 2021

Язык: Английский

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Notch signaling pathway: architecture, disease, and therapeutics

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Март 24, 2022

Abstract The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that signaling is an evolutionarily conserved pathway. receptors undergo three cleavages and translocate into the nucleus to regulate transcription of target genes. deeply participates in development homeostasis multiple tissues organs, aberration which results cancerous noncancerous diseases. However, recent indicate outcomes are changeable highly dependent on context. In terms cancers, can both promote inhibit tumor various types cancer. overall performance NOTCH-targeted therapies clinical trials has failed meet expectations. Additionally, mutation been proposed as a predictive biomarker for immune checkpoint blockade therapy many cancers. Collectively, pathway needs be integrally assessed with new perspectives inspire discoveries applications. this review, we focus classical latest findings related illustrate history, architecture, regulatory mechanisms, contributions physiological development, diseases, therapeutic applications microenvironment cancer immunotherapy also highlighted. We hope review will help not only beginners but experts systematically thoroughly understand

Язык: Английский

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Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Окт. 17, 2019

Human T cells coordinate adaptive immunity in diverse anatomic compartments through production of cytokines and effector molecules, but it is unclear how tissue site influences cell persistence function. Here, we use single RNA-sequencing (scRNA-seq) to define the heterogeneity human isolated from lungs, lymph nodes, bone marrow blood, their functional responses following stimulation. Through analysis >50,000 resting activated cells, reveal signatures mucosal lymphoid sites, lineage-specific activation states across all sites including distinct for CD8+ an interferon-response state CD4+ cells. Comparing scRNA-seq profiles tumor-associated our dataset reveals predominant compared within multiple tumor types. Our results therefore establish a high dimensional reference map health analyzing disease.

Язык: Английский

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Location, location, location: Tissue resident memory T cells in mice and humans

Science Immunology, Год журнала: 2019, Номер 4(34)

Опубликована: Апрель 5, 2019

The discovery of T cells resident in diverse tissues has altered our understanding adaptive immunity to encompass site-specific responses mediated by tissue-adapted memory throughout the body. Here, we discuss key phenotypic, transcriptional, and functional features these tissue-resident (TRM) as established mouse models infection translated humans novel tissue sampling approaches. Integration findings from human studies may hold unlocking potential TRM for promoting preventing infection.

Язык: Английский

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