Cytokine Circuits in Cardiovascular Disease

Immunity, Год журнала: 2019, Номер 50(4), С. 941 - 954

Опубликована: Апрель 1, 2019

Язык: Английский

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CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential

Frontiers in Immunology, Год журнала: 2019, Номер 10

Опубликована: Июнь 7, 2019

CD83 is a member of the immunoglobulin (Ig) superfamily and expressed in membrane bound or soluble forms. Membrane (mCD83) can be detected on variety activated immune cells, although it most highly stably by mature dendritic cells (DC). mCD83 regulates maturation, activation homeostasis. Soluble (sCD83), which elevated serum patients with autoimmune disease some hematological malignancies reported to have an suppressive function. While emerging as promising modulator therapeutic potential, important aspects such its ligand/s, intracellular signaling pathways modulators expression are unclear. In this review we discuss recent biological findings potential clinical value based therapeutics various conditions including disease, graft-vs.-host transplantation malignancies.

Язык: Английский

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Autoimmunity, Autoinflammation, and Infection in Uveitis

American Journal of Ophthalmology, Год журнала: 2018, Номер 189, С. 77 - 85

Опубликована: Март 3, 2018

To review the pathogenesis of uveitis in light recent advances our understanding innate and adaptive immune responses their regulation.Perspective.Methods included a prevailing views on an analysis developments immunology that impact its conceptual basis, particularly concept immunologic tolerance loss autoimmunity. Importantly, role infection is evaluated.The results comprise reappraisal anterior vs posterior context blood-retinal barrier relation to autoimmune, autoinflammatory, infectious uveitis. Autoimmunity seen as possible cause certain forms but definitive proof lacking. Autoinflammatory disease, involving activated mechanisms, considered causative second set conditions. A place for generally proposed within unifying uveitis.Infection may be implicated directly or indirectly many noninfectious undifferentiated In addition growing recognition foreign antigen, including reactivatable agents, might hide ocular tissues, possibility dysregulated microbiome generate T cells immune-mediated inflammation has now been demonstrated experimentally. An uncontrolled, overexuberant host response continuing irreversible tissue damage even after cleared.

Язык: Английский

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Immune Privilege and Eye-Derived T-Regulatory Cells

Journal of Immunology Research, Год журнала: 2018, Номер 2018, С. 1 - 12

Опубликована: Янв. 1, 2018

Certain cellular components of the eye, such as neural retina, are unable to regenerate and replicate after destructive inflammation. Ocular immune privilege provides eye with protection against intraocular inflammation in order minimize risk vision integrity. The system use strategies maintain ocular by regulating innate adaptive response, which includes immunological ignorance, peripheral tolerance eye-derived antigens, immunosuppressive microenvironment. In this review, we summarize current knowledge regarding molecular mechanism responsible for development maintenance via regulatory T cells (Tregs), generated anterior chamber-associated deviation (ACAID), resident including corneal endothelial (CE) cells, pigment epithelial (PE) aqueous humor. Furthermore, examined therapeutic potential Tregs RPE that express transforming growth factor beta (TGF- β ), cytotoxic lymphocyte-associated antigen-2 alpha (CTLA-2 α retinoic acid autoimmune uveoretinitis evaluated a new strategy using human RPE-induced clinical application inflammatory disease. We believe better understanding associated might offer approach regard interventions autoimmunity.

Язык: Английский

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The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(16), С. 4009 - 4009

Опубликована: Авг. 17, 2019

Ozone (O

Язык: Английский

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