Molecular Aspects of Medicine,
Год журнала:
2020,
Номер
74, С. 100894 - 100894
Опубликована: Авг. 1, 2020
Acute
inflammation
is
a
protective
reaction
by
the
immune
system
in
response
to
invading
pathogens
or
tissue
damage.
Ideally,
should
be
localized,
self-limited,
and
returning
homeostasis.
If
not
resolved,
acute
can
result
organ
pathologies
leading
chronic
inflammatory
phenotypes.
resolution
are
complex
coordinated
processes,
involving
number
of
cell
types,
interacting
space
time.
The
biomolecular
complexity
fact
that
several
biomedical
fields
involved,
make
multi-
interdisciplinary
approach
necessary.
Atlas
Inflammation
Resolution
(AIR)
web-based
resource
capturing
an
essential
part
state-of-the-art
research.
AIR
provides
interface
for
users
search
thousands
interactions,
arranged
inter-connected
multi-layers
process
diagrams,
covering
wide
range
clinically
relevant
By
mapping
experimental
data
onto
AIR,
it
used
elucidate
drug
action
as
well
molecular
mechanisms
underlying
different
disease
For
visualization
exploration
information,
uses
Minerva
platform,
which
well-established
tool
presentation
maps.
details
encoded
using
international
standards.
was
created
freely
accessible
resource,
supporting
research
education
resolution.
connects
communities,
facilitates
clinical
decision
making,
supports
scientists
formulation
validation
hypotheses.
through
https://air.bio.informatik.uni-rostock.de
Annual Review of Pathology Mechanisms of Disease,
Год журнала:
2019,
Номер
15(1), С. 123 - 147
Опубликована: Сен. 18, 2019
Macrophages
are
a
diverse
set
of
cells
present
in
all
body
compartments.
This
diversity
is
imprinted
by
their
ontogenetic
origin
(embryonal
versus
adult
bone
marrow-derived
cells);
the
organ
context;
activation
or
deactivation
various
signals
contexts
microbial
invasion,
tissue
damage,
and
metabolic
derangement;
polarization
adaptive
T
cell
responses.
Classic
responses
macrophages
include
tolerance,
priming,
wide
spectrum
states,
including
M1,
M2,
M2-like.
Moreover,
can
retain
long-term
imprinting
encounters
(trained
innate
immunity).
Single-cell
analysis
mononuclear
phagocytes
health
disease
has
added
new
dimension
to
our
understanding
macrophage
differentiation
activation.
Epigenetic
landscapes,
transcription
factors,
microRNA
networks
underlie
adaptability
different
environmental
cues.
Macrophage
plasticity,
an
essential
component
chronic
inflammation,
its
involvement
human
diseases,
most
notably
cancer,
discussed
here
as
paradigm.
Antioxidants,
Год журнала:
2019,
Номер
8(2), С. 35 - 35
Опубликована: Фев. 5, 2019
Inflammation
has
been
reported
to
be
intimately
linked
the
development
or
worsening
of
several
non-infectious
diseases.
A
number
chronic
conditions
such
as
cancer,
diabetes,
cardiovascular
disorders,
autoimmune
diseases,
and
neurodegenerative
disorders
emerge
a
result
tissue
injury
genomic
changes
induced
by
constant
low-grade
inflammation
in
around
affected
organ.
The
existing
therapies
for
most
these
sometimes
leave
more
debilitating
effects
than
disease
itself,
warranting
advent
safer,
less
toxic,
cost-effective
therapeutic
alternatives
patients.
For
centuries,
flavonoids
their
preparations
have
used
treat
various
human
illnesses,
continual
use
persevered
throughout
ages.
This
review
focuses
on
anti-inflammatory
actions
against
illnesses
neuroinflammation
with
special
focus
apigenin,
relatively
toxic
non-mutagenic
flavonoid
remarkable
pharmacodynamics.
Additionally,
central
nervous
system
(CNS)
due
diseases
multiple
sclerosis
(MS)
gives
ready
access
circulating
lymphocytes,
monocytes/macrophages,
dendritic
cells
(DCs),
causing
edema,
further
inflammation,
demyelination.
As
dearth
safe
is
dire
case
CNS-related
we
reviewed
neuroprotective
apigenin
other
flavonoids.
Existing
epidemiological
pre-clinical
studies
present
considerable
evidence
favor
developing
natural
alternative
therapy
inflammatory
conditions.
Genes & Development,
Год журнала:
2021,
Номер
35(11-12), С. 787 - 820
Опубликована: Июнь 1, 2021
Colorectal
cancer
has
served
as
a
genetic
and
biological
paradigm
for
the
evolution
of
solid
tumors,
these
insights
have
illuminated
early
detection,
risk
stratification,
prevention,
treatment
principles.
Employing
hallmarks
framework,
we
provide
conceptual
framework
to
understand
how
alterations
in
colorectal
drive
cell
biology
properties
shape
heterotypic
interactions
across
cells
tumor
microenvironment.
This
review
details
research
advances
pertaining
genetics
cancer,
emerging
concepts
gleaned
from
immune
single-cell
profiling,
critical
remaining
knowledge
gaps
influencing
development
effective
therapies
this
that
remains
major
public
health
burden.
Nature Communications,
Год журнала:
2018,
Номер
9(1)
Опубликована: Авг. 9, 2018
Inflammation
and
its
resolution
is
under-studied
in
medicine
despite
being
essential
for
understanding
the
development
of
chronic
inflammatory
disease.
In
this
review
article,
we
discuss
inflammation
both
a
biological
translational
context.
We
introduce
concept
impaired
leading
to
diseases
like
rheumatoid
arthritis,
Crohn's
disease,
asthma,
as
well
cellular
molecular
components
that
contribute
joint,
gut,
lung
inflammation,
respectively.
Finally,
potential
intervention
strategies
fostering
process,
their
implications
therapy
diseases.
Immunological Reviews,
Год журнала:
2017,
Номер
281(1), С. 57 - 61
Опубликована: Дек. 16, 2017
Summary
Inflammation
is
an
important
component
of
the
tumor
microenvironment.
IL
‐1
inflammatory
cytokine
which
plays
a
key
role
in
carcinogenesis
and
progression.
subject
to
regulation
by
components
receptor
(
ILR
)
families.
Negative
regulators
include
decoy
‐1R2),
antagonists
‐1Ra),
‐1R8,
anti‐inflammatory
‐37.
acts
at
different
levels
initiation
progression,
including
driving
chronic
non‐resolving
inflammation,
angiogenesis,
activation
‐17
pathway,
induction
myeloid‐derived
suppressor
cells
MDSC
macrophage
recruitment,
invasion
metastasis.
Based
on
initial
clinical
results,
translation
potential
targeting
deserves
extensive
analysis.
Gut,
Год журнала:
2021,
Номер
70(10), С. 1978 - 1988
Опубликована: Июнь 18, 2021
The
incidence
of
inflammatory
bowel
diseases
(IBD)
emerged
with
Westernisation
dietary
habits
worldwide.
Crohn's
disease
and
ulcerative
colitis
are
chronic
debilitating
conditions
that
afflict
individuals
substantial
morbidity
challenge
healthcare
systems
across
the
globe.
Since
identification
characterisation
calprotectin
(CP)
in
1980s,
faecal
CP
as
significantly
validated,
non-invasive
biomarker
allows
evaluation
gut
inflammation.
Faecal
discriminates
between
non-inflammatory
portraits
course
human
IBD.
Recent
studies
revealed
insights
into
biological
functions
subunits
S100A8
S100A9
during
orchestration
an
response
at
mucosal
surfaces
organ
systems.
In
this
review,
we
summarise
longitudinal
evidence
for
evolution
from
to
rheostat
inflammation
suggest
algorithm
interpretation
daily
clinical
practice.
We
propose
mechanistic
function
beyond
may
facilitate
current
assays
guide
patient-tailored
medical
therapy
IBD,
a
concept
warranting
controlled
trials.
