Genome Regulation by Polycomb and Trithorax: 70 Years and Counting

Cell, Год журнала: 2017, Номер 171(1), С. 34 - 57

Опубликована: Сен. 1, 2017

Язык: Английский

---

How many human proteoforms are there?

Nature Chemical Biology, Год журнала: 2018, Номер 14(3), С. 206 - 214

Опубликована: Фев. 14, 2018

Язык: Английский

---

CGCG clinical practice guidelines for the management of adult diffuse gliomas

Cancer Letters, Год журнала: 2016, Номер 375(2), С. 263 - 273

Опубликована: Март 7, 2016

The Chinese Glioma Cooperative Group (CGCG) Guideline Panel for adult diffuse gliomas provided recommendations diagnostic and therapeutic procedures. covered all fields of expertise in neuro-oncology, i.e. neurosurgeons, neurologists, neuropathologists, neuroradiologists, radiation medical oncologists clinical trial experts. task made clearer more transparent choices about outcomes considered most relevant through searching the references evaluating their value. scientific evidence papers collected from literature was evaluated graded based on Oxford Centre Evidence-based Medicine Levels Evidence were given accordingly. will provide a framework assurance strategy measures to reduce complications unnecessary treatment cost. guideline should serve as an application professionals involved management patients with glioma also source knowledge insurance companies other institutions cost regulation cancer care China.

Язык: Английский

---

The roles of DNA, RNA and histone methylation in ageing and cancer

Nature Reviews Molecular Cell Biology, Год журнала: 2019, Номер 20(10), С. 573 - 589

Опубликована: Июль 3, 2019

Язык: Английский

---

Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

Nature Medicine, Год журнала: 2017, Номер 23(11), С. 1352 - 1361

Опубликована: Окт. 9, 2017

Язык: Английский

---

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Март 19, 2019

Abstract Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M tumor lines isogenic CRISPR-edited controls to assess effects vitro vivo. We find that whereas H3K27me3 H3K27me2 are normally deposited by PRC2 across broad regions, their deposition is severely reduced H3.3K27M cells. unable spread from large unmethylated CpG islands, while can be outside these high-affinity sites but levels corresponding wild-type Our findings indicate recruitment propagation on chromatin seemingly unaffected K27M, which mostly impairs the repressive marks it catalyzes, especially H3K27me3. Genome-wide loss me2 has limited transcriptomic consequences, preferentially affecting lowly-expressed regulating neurogenesis. Removal restores H3K27me2/me3 spread, cell proliferation, completely abolishes capacity form tumors mice.

Язык: Английский

---

The roles of Polycomb repressive complexes in mammalian development and cancer

Nature Reviews Molecular Cell Biology, Год журнала: 2021, Номер 22(5), С. 326 - 345

Опубликована: Март 15, 2021

Язык: Английский

---

Clinical practice guidelines for the management of adult diffuse gliomas

Cancer Letters, Год журнала: 2020, Номер 499, С. 60 - 72

Опубликована: Ноя. 6, 2020

Язык: Английский

---

Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation

Nature Genetics, Год журнала: 2020, Номер 52(12), С. 1271 - 1281

Опубликована: Ноя. 30, 2020

Язык: Английский

---

Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression

Cancer Cell, Год журнала: 2018, Номер 35(1), С. 140 - 155.e7

Опубликована: Дек. 27, 2018

Язык: Английский

---