Cell Death and Differentiation,
Год журнала:
2018,
Номер
25(3), С. 486 - 541
Опубликована: Янв. 23, 2018
Over
the
past
decade,
Nomenclature
Committee
on
Cell
Death
(NCCD)
has
formulated
guidelines
for
definition
and
interpretation
of
cell
death
from
morphological,
biochemical,
functional
perspectives.
Since
field
continues
to
expand
novel
mechanisms
that
orchestrate
multiple
pathways
are
unveiled,
we
propose
an
updated
classification
subroutines
focusing
mechanistic
essential
(as
opposed
correlative
dispensable)
aspects
process.
As
provide
molecularly
oriented
definitions
terms
including
intrinsic
apoptosis,
extrinsic
mitochondrial
permeability
transition
(MPT)-driven
necrosis,
necroptosis,
ferroptosis,
pyroptosis,
parthanatos,
entotic
death,
NETotic
lysosome-dependent
autophagy-dependent
immunogenic
cellular
senescence,
mitotic
catastrophe,
discuss
utility
neologisms
refer
highly
specialized
instances
these
processes.
The
mission
NCCD
is
a
widely
accepted
nomenclature
in
support
continued
development
field.
JAMA,
Год журнала:
2021,
Номер
325(6), С. 568 - 568
Опубликована: Фев. 9, 2021
Importance
Osteoarthritis
(OA)
is
the
most
common
joint
disease,
affecting
an
estimated
more
than
240
million
people
worldwide,
including
32
in
US.
frequent
reason
for
activity
limitation
adults.
This
Review
focuses
on
hip
and
knee
OA.
Observations
can
involve
almost
any
but
typically
affects
hands,
knees,
hips,
feet.
It
characterized
by
pathologic
changes
cartilage,
bone,
synovium,
ligament,
muscle,
periarticular
fat,
leading
to
dysfunction,
pain,
stiffness,
functional
limitation,
loss
of
valued
activities,
such
as
walking
exercise
dancing.
Risk
factors
include
age
(33%
individuals
older
75
years
have
symptomatic
radiographic
OA),
female
sex,
obesity,
genetics,
major
injury.
Persons
with
OA
comorbidities
are
sedentary
those
without
The
reduced
physical
leads
a
20%
higher
age-adjusted
mortality.
Several
examination
findings
useful
diagnostically,
bony
enlargement
pain
elicited
internal
rotation
Radiographic
indicators
marginal
osteophytes
space
narrowing.
cornerstones
management
exercises,
weight
if
appropriate,
education—complemented
topical
or
oral
nonsteroidal
anti-inflammatory
drugs
(NSAIDs)
contraindications.
Intra-articular
steroid
injections
provide
short-term
relief
duloxetine
has
demonstrated
efficacy.
Opiates
should
be
avoided.
Clinical
trials
shown
promising
results
compounds
that
arrest
structural
progression
(eg,
cathepsin
K
inhibitors,
Wnt
anabolic
growth
factors)
reduce
nerve
factor
inhibitors).
advanced
symptoms
damage
candidates
total
replacement.
Racial
ethnic
disparities
persist
use
outcomes
Conclusions
Relevance
Hip
highly
prevalent
disabling.
Education,
management,
complemented
NSAIDs
(for
patients
who
candidates),
corticosteroid
injections,
several
adjunctive
medications.
For
persons
damage,
replacement
effectively
relieves
pain.
The Journal of Cell Biology,
Год журнала:
2017,
Номер
217(1), С. 65 - 77
Опубликована: Ноя. 7, 2017
Aging
is
the
major
risk
factor
for
cancer,
cardiovascular
disease,
diabetes,
and
neurodegenerative
disorders.
Although
we
are
far
from
understanding
biological
basis
of
aging,
research
suggests
that
targeting
aging
process
itself
could
ameliorate
many
age-related
pathologies.
Senescence
a
cellular
response
characterized
by
stable
growth
arrest
other
phenotypic
alterations
include
proinflammatory
secretome.
plays
roles
in
normal
development,
maintains
tissue
homeostasis,
limits
tumor
progression.
However,
senescence
has
also
been
implicated
as
cause
disease.
In
this
regard,
recent
experimental
evidence
shown
genetic
or
pharmacological
ablation
senescent
cells
extends
life
span
improves
health
span.
Here,
review
molecular
links
between
discuss
novel
therapeutic
avenues
connection
opens.
Physiological Reviews,
Год журнала:
2019,
Номер
99(2), С. 1047 - 1078
Опубликована: Янв. 16, 2019
Cellular
senescence
is
a
permanent
state
of
cell
cycle
arrest
that
occurs
in
proliferating
cells
subjected
to
different
stresses.
Senescence
is,
therefore,
cellular
defense
mechanism
prevents
the
acquire
an
unnecessary
damage.
The
senescent
accompanied
by
failure
re-enter
response
mitogenic
stimuli,
enhanced
secretory
phenotype
and
resistance
death.
takes
place
several
tissues
during
physiological
pathological
processes
such
as
tissue
remodeling,
injury,
cancer,
aging.
Although
one
causative
aging
it
responsible
aging-related
disorders,
can
also
play
positive
role.
In
embryogenesis
are
required
for
proper
development
embryo
repair.
works
potent
barrier
prevent
tumorigenesis.
Therefore,
identification
characterization
key
features
senescence,
induction
cancer
cells,
or
elimination
pharmacological
interventions
gaining
consideration
fields
research.
Here,
we
describe
known
cell-autonomous,
noncell-autonomous
regulators
attempt
discuss
functional
role
this
fundamental
process
contexts
light
novel
therapeutic
targets.
