Ageing Research Reviews,
Год журнала:
2020,
Номер
66, С. 101249 - 101249
Опубликована: Дек. 29, 2020
Osteoarthritis
(OA)
is
a
degenerative
joint
disease
characterized
by
low-grade
inflammation
and
high
levels
of
clinical
heterogeneity.
Aberrant
chondrocyte
metabolism
response
to
changes
in
the
inflammatory
microenvironment
may
play
key
role
cartilage
degeneration
OA
progression.
Under
conditions
environmental
stress,
chondrocytes
tend
adapt
their
microenvironmental
shifting
from
one
metabolic
pathway
another,
for
example
oxidative
phosphorylation
glycolysis.
Similar
occur
other
cells,
including
synoviocytes.
Switching
between
these
pathways
implicated
alterations
that
involve
mitochondrial
dysfunction,
enhanced
anaerobic
glycolysis,
altered
lipid
amino
acid
metabolism.
The
shift
glycolysis
mainly
regulated
AMP-activated
protein
kinase
(AMPK)
mechanistic
target
rapamycin
(mTOR)
pathways.
Chondrocyte
are
likely
be
feature
different
phenotypes.
Determining
has
revealed
features
pathogenesis.
Future
research
should
place
greater
emphasis
on
immunometabolism
as
means
understand
pathophysiology
age-related
OA.
This
knowledge
will
advance
development
new
drugs
against
therapeutic
targets
significance.
