Hydrogels with tunable stress relaxation regulate stem cell fate and activity

Nature Materials, Год журнала: 2015, Номер 15(3), С. 326 - 334

Опубликована: Ноя. 30, 2015

Язык: Английский

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A practical guide to hydrogels for cell culture

Nature Methods, Год журнала: 2016, Номер 13(5), С. 405 - 414

Опубликована: Апрель 28, 2016

Язык: Английский

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Mechanical forces direct stem cell behaviour in development and regeneration

Nature Reviews Molecular Cell Biology, Год журнала: 2017, Номер 18(12), С. 728 - 742

Опубликована: Ноя. 8, 2017

Язык: Английский

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Advancing biomaterials of human origin for tissue engineering

Progress in Polymer Science, Год журнала: 2015, Номер 53, С. 86 - 168

Опубликована: Апрель 11, 2015

Язык: Английский

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A Review of Cell Adhesion Studies for Biomedical and Biological Applications

International Journal of Molecular Sciences, Год журнала: 2015, Номер 16(8), С. 18149 - 18184

Опубликована: Авг. 5, 2015

Cell adhesion is essential in cell communication and regulation, of fundamental importance the development maintenance tissues. The mechanical interactions between a its extracellular matrix (ECM) can influence control behavior function. function has created tremendous interests developing methods for measuring studying properties. study could be categorized into attachment detachment events. been widely explored via both events many important purposes cellular biology, biomedical, engineering fields. further grouped population single approach. Various techniques to measure have applied fields order gain understanding signaling pathways, biomaterial studies implantable sensors, artificial bone tooth replacement, tissue-on-a-chip organ-on-a-chip tissue engineering, effects biochemical treatments environmental stimuli adhesion, potential drug treatments, cancer metastasis study, determination properties normal cancerous cells. This review discussed overview available through

Язык: Английский

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Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment

Chemical Reviews, Год журнала: 2017, Номер 117(20), С. 12764 - 12850

Опубликована: Окт. 9, 2017

The cell microenvironment has emerged as a key determinant of behavior and function in development, physiology, pathophysiology. extracellular matrix (ECM) within the serves not only structural foundation for cells but also source three-dimensional (3D) biochemical biophysical cues that trigger regulate behaviors. Increasing evidence suggests 3D character is required development many critical responses observed vivo, fueling surge functional biomimetic materials engineering microenvironment. Progress design such improved control behaviors advanced fields tissue regeneration, vitro models, large-scale differentiation, immunotherapy, gene therapy. However, field still its infancy, discoveries about nature cell–microenvironment interactions continue to overturn much early progress field. Key challenges be dissecting roles chemistry, structure, mechanics, electrophysiology microenvironment, understanding harnessing periodicity drift these factors. This review encapsulates where recent advances appear leave ever-shifting state art, it highlights areas which substantial potential uncertainty remain.

Язык: Английский

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3D Bioprinting for Tissue and Organ Fabrication

Annals of Biomedical Engineering, Год журнала: 2016, Номер 45(1), С. 148 - 163

Опубликована: Апрель 28, 2016

Язык: Английский

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Collective cell durotaxis emerges from long-range intercellular force transmission

Science, Год журнала: 2016, Номер 353(6304), С. 1157 - 1161

Опубликована: Сен. 8, 2016

The ability of cells to follow gradients extracellular matrix stiffness-durotaxis-has been implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that exhibited durotaxis even if isolated constituent did not. This emergent mode directed collective cell migration applied a variety epithelial types, required the action myosin motors, originated from supracellular transmission contractile physical forces. To explain observed phenomenology, developed generalized clutch model which local stick-slip dynamics cell-matrix adhesions was integrated tissue level through cell-cell junctions. Collective is far more efficient than single-cell durotaxis; it thus emerges as robust mechanism direct during wound healing, cancer invasion.

Язык: Английский

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Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks

Trends in biotechnology, Год журнала: 2016, Номер 34(9), С. 733 - 745

Опубликована: Март 28, 2016

Язык: Английский

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The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship

Matrix Biology, Год журнала: 2015, Номер 47, С. 54 - 65

Опубликована: Май 8, 2015

Physiological tissue repair aims at restoring the mechano-protective properties of extracellular matrix. Consequently, redundant regulatory mechanisms are in place ensuring that remodeling terminates once matrix homeostasis is re-established. If these fail, stromal cells become continuously activated, accumulate excessive amounts stiff matrix, and fibrosis develops. In this mini-review, I develop hypothesis mechanical state pro-fibrotic transforming growth factor (TGF)-β1 cooperate to regulate activities cells. TGF-β1 stored as part a large latent complex can be activated by cell contractile force transmitted integrins. Matrix straining stiffening lower threshold for activation increasing resistance pulling. Different elements mechanism pharmacologically targeted interrupt positive feedback loop fibrosis, including specific integrins protein interactions.

Язык: Английский

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