Neural Circuit Mechanisms of Social Behavior

Neuron, Год журнала: 2018, Номер 98(1), С. 16 - 30

Опубликована: Апрель 1, 2018

Язык: Английский

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Brain rhythms and neural syntax: implications for efficient coding of cognitive content and neuropsychiatric disease.

Dialogues in Clinical Neuroscience, Год журнала: 2012, Номер 14(4), С. 345 - 367

Опубликована: Дек. 31, 2012

The perpetual activity of the cerebral cortex is largely supported by variety oscillations brain generates, spanning a number frequencies and anatomical locations, as well behavioral correlates. First, we review findings from animal studies showing that most forms rhythms are inhibition-based, producing rhythmic volleys inhibitory inputs to principal cell populations, thereby providing alternating temporal windows relatively reduced enhanced excitability in neuronal networks. These inhibition-based mechanisms offer natural frames group or "chunk" into assemblies sequences assemblies, with more complex multi-oscillation interactions creating syntactical rules for effective exchange information among cortical We then recent human psychiatric patients demonstrating alterations neural across all major diseases, suggest possible future research directions treatment approaches based on fundamental properties rhythms.

Язык: Английский

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Autism-Associated Neuroligin-3 Mutations Commonly Impair Striatal Circuits to Boost Repetitive Behaviors

Cell, Год журнала: 2014, Номер 158(1), С. 198 - 212

Опубликована: Июль 1, 2014

Язык: Английский

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The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior

ACS Chemical Neuroscience, Год журнала: 2017, Номер 8(5), С. 955 - 960

Опубликована: Март 13, 2017

The forced swim test (FST) measures coping strategy to an acute inescapable stress and thus provides unique insight into the neural limb of response. Stress, particularly chronic stress, is a contributing factor depression in humans associated with altered response stress. In addition, drugs that are effective antidepressants typically promote active FST. As consequence, passive FST has become loosely equated often referred as "depression-like" behavior. This terminology oversimplifies complex biology misrepresents both utility limitations little construct- or face-validity support interpretation While arguably relevant depression, there likely many factors can influence strategy. Importantly, other neuropsychiatric disorders characterized by responses difficulty adapting change. One these autism spectrum disorder (ASD), several mouse genetic models ASD exhibit stress-coping strategies Here we review evidence argues more thoughtful consideration FST, precise terminology, would benefit study which include but not limited depression.

Язык: Английский

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Sex differences in anxiety and depression: Role of testosterone

Frontiers in Neuroendocrinology, Год журнала: 2013, Номер 35(1), С. 42 - 57

Опубликована: Сен. 24, 2013

Язык: Английский

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