Annual Review of Physiology,
Год журнала:
2016,
Номер
79(1), С. 401 - 423
Опубликована: Дек. 3, 2016
The
neural
control
of
appetite
is
important
for
understanding
motivated
behavior
as
well
the
present
rising
prevalence
obesity.
Over
past
several
years,
new
tools
cell
type-specific
neuron
activity
monitoring
and
perturbation
have
enabled
increasingly
detailed
analyses
mechanisms
underlying
appetite-control
systems.
Three
major
circuits
strongly
acutely
influence
but
with
notably
different
characteristics.
Although
these
interact,
they
distinct
properties
thus
appear
to
contribute
separate
interlinked
processes
influencing
appetite,
thereby
forming
three
pillars
control.
Here,
we
summarize
some
key
characteristics
that
are
emerging
from
recent
work
synthesize
findings
into
a
provisional
framework
can
guide
future
studies.
Science,
Год журнала:
2013,
Номер
340(6129), С. 211 - 216
Опубликована: Апрель 11, 2013
Successful
integration
of
advanced
semiconductor
devices
with
biological
systems
will
accelerate
basic
scientific
discoveries
and
their
translation
into
clinical
technologies.
In
neuroscience
generally,
in
optogenetics
particular,
the
ability
to
insert
light
sources,
detectors,
sensors,
other
components
precise
locations
deep
brain
yields
versatile
important
capabilities.
Here,
we
introduce
an
injectable
class
cellular-scale
optoelectronics
that
offers
such
features,
examples
unmatched
operational
modes
optogenetics,
including
completely
wireless
programmed
complex
behavioral
control
over
freely
moving
animals.
The
these
ultrathin,
mechanically
compliant,
biocompatible
afford
minimally
invasive
operation
soft
tissues
mammalian
foreshadow
applications
organ
systems,
potential
for
broad
utility
biomedical
science
engineering.
