Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Nature Reviews Neurology, Год журнала: 2020, Номер 17(3), С. 157 - 172

Опубликована: Дек. 14, 2020

Язык: Английский

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Interactions between the microbiota, immune and nervous systems in health and disease

Nature Neuroscience, Год журнала: 2017, Номер 20(2), С. 145 - 155

Опубликована: Янв. 16, 2017

Язык: Английский

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Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

Nature Medicine, Год журнала: 2016, Номер 22(6), С. 586 - 597

Опубликована: Май 9, 2016

Язык: Английский

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Transfer of mitochondria from astrocytes to neurons after stroke

Nature, Год журнала: 2016, Номер 535(7613), С. 551 - 555

Опубликована: Июль 26, 2016

Язык: Английский

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Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Nature reviews. Neuroscience, Год журнала: 2017, Номер 18(7), С. 419 - 434

Опубликована: Май 18, 2017

Язык: Английский

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The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease

Nature reviews. Immunology, Год журнала: 2019, Номер 19(3), С. 184 - 197

Опубликована: Фев. 4, 2019

Язык: Английский

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Microglial control of astrocytes in response to microbial metabolites

Nature, Год журнала: 2018, Номер 557(7707), С. 724 - 728

Опубликована: Май 1, 2018

Язык: Английский

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Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

Neuron, Год журнала: 2017, Номер 95(3), С. 531 - 549.e9

Опубликована: Июль 14, 2017

Astrocytes are ubiquitous in the brain and widely held to be largely identical. However, this view has not been fully tested, possibility that astrocytes neural circuit specialized remains unexplored. Here, we used multiple integrated approaches, including RNA sequencing (RNA-seq), mass spectrometry, electrophysiology, immunohistochemistry, serial block-face-scanning electron microscopy, morphological reconstructions, pharmacogenetics, diffusible dye, calcium, glutamate imaging, directly compare adult striatal hippocampal under identical conditions. We found significant differences electrophysiological properties, Ca2+ signaling, morphology, astrocyte-synapse proximity between astrocytes. Unbiased evaluation of actively translated proteomic data confirmed astrocyte diversity circuits. thus report core reveal evidence for within circuits, provide new, database resources approaches explore function throughout brain.Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiI0OGY5MjVkMzgwOGU0NTkwZGMzNTRhMjQwZjZkMWM0OCIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc3ODAzMzg0fQ.MwSBbMAp8Z94bVovEvEtEK9rSaCme1FWQaVStp6O8krax6PBRClksqtYhGWrI6xK8ct9tTpHJOavNya9agX01pfBV5Xv2_BxcAlr-eYdkIlnW6ddiNKQ9_7eEHZulgpmyVbQq2DLjKc1qNoV1ABBLI5qYU4yHQPnu-EI2_RASm5h1NErzRmbGIHeglc9V82L8hZBX8NyvUw74JxMPzvU4cgxuX5JBvnXBUOvw2oTkF0oPeBvpSchW6EKQzen4Skxhu-LXb5aAa3LkCMU3JhcCep28BCCVsKkV1kx3RuXhdJgkWD2ucI-70LBWqUvhtG-49ThFs0TB8dIBr74DrFLKA(mp4, (55.46 MB) Download video

Язык: Английский

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Identification of region-specific astrocyte subtypes at single cell resolution

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Март 5, 2020

Abstract Astrocytes, a major cell type found throughout the central nervous system, have general roles in modulation of synapse formation and synaptic transmission, blood–brain barrier formation, regulation blood flow, as well metabolic support other brain resident cells. Crucially, emerging evidence shows specific adaptations astrocyte-encoded functions regions, such spinal cord cerebellum. To investigate true extent astrocyte molecular diversity across forebrain we used single-cell RNA sequencing. Our analysis identifies five transcriptomically distinct subtypes adult mouse cortex hippocampus. Validation our data situ reveals spatial positioning defined subtypes, reflecting distribution morphologically physiologically populations. findings are for specialized between within regions. The available through an online database ( https://holt-sc.glialab.org/ ), providing resource on which to base explorations local function brain.

Язык: Английский

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Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

Journal of Neuroinflammation, Год журнала: 2019, Номер 16(1)

Опубликована: Март 1, 2019

Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under physiological pathological conditions. Although there anatomical separation, emerging evidence has indicated the existence bidirectional interaction between gut microbiota, i.e., (diverse microorganisms colonizing human intestine), brain. The cross-talk microbiota brain may crucial impact during basic neurogenerative processes, in neurodegenerative disorders tumors CNS. In this review, we discuss biological interplay gut-brain axis, further explore how communication be dysregulated diseases. Further, highlight new insights modification composition, which emerge as a promising therapeutic approach to treat CNS disorders.

Язык: Английский

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