Ventral tegmental area: cellular heterogeneity, connectivity and behaviour

Nature reviews. Neuroscience, Год журнала: 2017, Номер 18(2), С. 73 - 85

Опубликована: Янв. 5, 2017

Язык: Английский

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Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity

Disease Models & Mechanisms, Год журнала: 2017, Номер 10(6), С. 679 - 689

Опубликована: Июнь 1, 2017

ABSTRACT The ‘obesity epidemic’ represents a major global socioeconomic burden that urgently calls for better understanding of the underlying causes increased weight gain and its associated metabolic comorbidities, such as type 2 diabetes mellitus cardiovascular diseases. Improving our cellular basis obesity could set stage development new therapeutic strategies. CNS plays pivotal role in regulation energy glucose homeostasis. Distinct neuronal cell populations, particularly within arcuate nucleus hypothalamus, sense nutrient status organism integrate signals from peripheral hormones including pancreas-derived insulin adipocyte-derived leptin to regulate calorie intake, metabolism expenditure. neurons are tightly connected other specialized subpopulations but also various extrahypothalamic brain regions, allowing coordinated behavioral response. This At Glance article gives an overview recent knowledge, mainly derived rodent models, regarding CNS-dependent homeostasis, illustrates how dysregulation networks involved can lead overnutrition obesity. potential impact research findings field on treatment strategies human is discussed.

Язык: Английский

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The transition to compulsion in addiction

Nature reviews. Neuroscience, Год журнала: 2020, Номер 21(5), С. 247 - 263

Опубликована: Март 30, 2020

Язык: Английский

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Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation

Neuron, Год журнала: 2016, Номер 90(6), С. 1286 - 1298

Опубликована: Май 28, 2016

Язык: Английский

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Overlapping Brain Circuits for Homeostatic and Hedonic Feeding

Cell Metabolism, Год журнала: 2017, Номер 27(1), С. 42 - 56

Опубликована: Ноя. 5, 2017

Язык: Английский

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Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons

Nature Neuroscience, Год журнала: 2019, Номер 22(4), С. 642 - 656

Опубликована: Март 11, 2019

Язык: Английский

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Hormonal gain control of a medial preoptic area social reward circuit

Nature Neuroscience, Год журнала: 2017, Номер 20(3), С. 449 - 458

Опубликована: Янв. 30, 2017

Язык: Английский

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Three Pillars for the Neural Control of Appetite

Annual Review of Physiology, Год журнала: 2016, Номер 79(1), С. 401 - 423

Опубликована: Дек. 3, 2016

The neural control of appetite is important for understanding motivated behavior as well the present rising prevalence obesity. Over past several years, new tools cell type-specific neuron activity monitoring and perturbation have enabled increasingly detailed analyses mechanisms underlying appetite-control systems. Three major circuits strongly acutely influence but with notably different characteristics. Although these interact, they distinct properties thus appear to contribute separate interlinked processes influencing appetite, thereby forming three pillars control. Here, we summarize some key characteristics that are emerging from recent work synthesize findings into a provisional framework can guide future studies.

Язык: Английский

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Evolving Concepts of Emotion and Motivation

Frontiers in Psychology, Год журнала: 2018, Номер 9

Опубликована: Сен. 7, 2018

This review takes a historical perspective on concepts in the psychology of motivation and emotion, surveys recent developments, debates applications. Old over emotion have recently risen again. For example, are emotions necessarily subjective feelings? Do animals emotions? I evidence that exist as core psychological processes, which objectively detectable features, can occur either with feelings or without them. Evidence is offered also studies give new insights into human emotions. Beyond changed decades too, still continue. Motivation was once thought terms aversive drives, reward drive reduction. Motivation-as-drive were largely replaced by motivation-as-incentive concepts, yet occasionally surface neuroscience today. Among incentive salience process, mediated brain mesocorticolimbic systems (dopamine-related systems) sometimes called 'wanting' (in quotation marks), to distinguish it from cognitive forms desire (wanting marks). Incentive separable pleasure 'liking' for same reward, has important implications several clinical disorders. Ordinarily, adds motivational urgency desires, but desires dissociate some conditions. Excessive cause addictions, excessive diverge desires. Conversely, lack may anhedonia depression schizophrenia, whereas negatively-valenced form 'fearful salience' contribute paranoia. Finally, negative 'fear' 'disgust' both partial overlap neural differences.

Язык: Английский

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Reward and Aversion

Annual Review of Neuroscience, Год журнала: 2016, Номер 39(1), С. 297 - 324

Опубликована: Май 5, 2016

To benefit from opportunities and cope with challenges in the environment, animals must adapt their behavior to acquire rewards avoid punishments. Maladaptive changes neuromodulatory systems neural circuits for reward aversion can lead manifestation of several prominent psychiatric disorders including addiction depression. Recent progress is pushing boundaries knowledge on two major fronts research aversion: First, new layers complexity have been reported functions dopamine (DA) serotonin (5-HT) aversion. Second, specific circuit components pathways that encode begun be identified. This review aims outline historic perspectives insights into DA 5-HT coding distinct rewards. It also highlights recent advances studies enabled by technologies, such as cell-type-specific electrophysiology tracing, optogenetics-based behavioral manipulation. may provide guidance developing novel treatment strategies neuropsychiatric diseases related malfunction system.

Язык: Английский

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