Neuroimmune Interactions in Peripheral Organs DOI Open Access
Roel G. J. Klein Wolterink, Glendon Wu, Isaac M. Chiu

и другие.

Annual Review of Neuroscience, Год журнала: 2022, Номер 45(1), С. 339 - 360

Опубликована: Апрель 1, 2022

Interactions between the nervous and immune systems were recognized long ago, but recent studies show that this crosstalk occurs more frequently than was previously appreciated. Moreover, technological advances have enabled identification of molecular mediators receptors enable interaction these two complex provide new insights on role neuroimmune in organismal physiology. Most interactions occur at discrete anatomical locations which neurons cells colocalize. Here, we describe different branches peripheral system with various organs, including skin, intestine, lung, adipose tissue. We highlight how orchestrates physiological processes such as host defense, tissue repair, metabolism, thermogenesis. Unraveling intricate relationships is invaluable to explore therapeutic potential interactions.

Язык: Английский

Depression and obesity: evidence of shared biological mechanisms DOI
Yuri Milaneschi, W. Kyle Simmons, Elisabeth F. C. van Rossum

и другие.

Molecular Psychiatry, Год журнала: 2018, Номер 24(1), С. 18 - 33

Опубликована: Фев. 16, 2018

Язык: Английский

Процитировано

807

Mechanisms and Therapeutic Relevance of Neuro-immune Communication DOI Creative Commons
Sangeeta S. Chavan, Valentin A. Pavlov, Kevin J. Tracey

и другие.

Immunity, Год журнала: 2017, Номер 46(6), С. 927 - 942

Опубликована: Июнь 1, 2017

Язык: Английский

Процитировано

543

Innate immune responses to trauma DOI
Markus Huber‐Lang, John D. Lambris, Peter A. Ward

и другие.

Nature Immunology, Год журнала: 2018, Номер 19(4), С. 327 - 341

Опубликована: Март 5, 2018

Язык: Английский

Процитировано

484

The pathogenesis of rheumatoid arthritis DOI Creative Commons
Stefano Alivernini, Gary S. Firestein, Iain B. McInnes

и другие.

Immunity, Год журнала: 2022, Номер 55(12), С. 2255 - 2270

Опубликована: Дек. 1, 2022

Язык: Английский

Процитировано

479

Molecular and Functional Neuroscience in Immunity DOI Open Access
Valentin A. Pavlov, Sangeeta S. Chavan, Kevin J. Tracey

и другие.

Annual Review of Immunology, Год журнала: 2018, Номер 36(1), С. 783 - 812

Опубликована: Апрель 20, 2018

The nervous system regulates immunity and inflammation. molecular detection of pathogen fragments, cytokines, other immune molecules by sensory neurons generates immunoregulatory responses through efferent autonomic neuron signaling. functional organization this neural control is based on principles reflex regulation. Reflexes involving the vagus nerve nerves have been therapeutically explored in models inflammatory autoimmune conditions, recently clinical settings. brain integrates neuro-immune communication, function altered diseases characterized peripheral dysregulation Here we review anatomical basis interface with immunity, focusing functions role model immunological homunculus. Clinical advances stemming from knowledge within framework bioelectronic medicine are also briefly outlined.

Язык: Английский

Процитировано

388

An Atlas of Vagal Sensory Neurons and Their Molecular Specialization DOI Creative Commons
Jussi Kupari, Martin Häring, Eneritz Agirre

и другие.

Cell Reports, Год журнала: 2019, Номер 27(8), С. 2508 - 2523.e4

Опубликована: Май 1, 2019

Sensory functions of the vagus nerve are critical for conscious perceptions and monitoring visceral in cardio-pulmonary gastrointestinal systems. Here, we present a comprehensive identification, classification, validation neuron types neural crest (jugular) placode (nodose) derived vagal ganglia by single-cell RNA sequencing (scRNA-seq) transcriptomic analysis. Our results reveal major differences between neurons from different embryonic origins. Jugular exhibit fundamental similarities to somatosensory spinal neurons, including types, such as C-low threshold mechanoreceptors (C-LTMRs), A-LTMRs, Aδ-nociceptors, cold-, mechano-heat C-nociceptors. In contrast, nodose ganglion contains 18 distinct dedicated surveying physiological state internal body. vast diversity many previously unanticipated well proposed that consistent with chemoreceptors, nutrient detectors, baroreceptors, stretch volume respiratory, gastrointestinal, cardiovascular

Язык: Английский

Процитировано

351

Neuroinflammation and Perioperative Neurocognitive Disorders DOI
Saraswathi Subramaniyan, Niccolò Terrando

Anesthesia & Analgesia, Год журнала: 2019, Номер 128(4), С. 781 - 788

Опубликована: Март 27, 2019

Neuroinflammation has become a key hallmark of neurological complications including perioperative pathologies such as postoperative delirium and longer-lasting cognitive dysfunction. Dysregulated inflammation neuronal injury are emerging from clinical studies features neurocognitive disorders. These findings paralleled by growing body preclinical investigations aimed at better understanding how surgery anesthesia affect the central nervous system possibly contribute to decline. Herein, we review role neuroinflammation underlying mechanisms in immune-to-brain signaling after peripheral surgery.

Язык: Английский

Процитировано

322

Expression and Function of the Cholinergic System in Immune Cells DOI Creative Commons
Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki

и другие.

Frontiers in Immunology, Год журнала: 2017, Номер 8

Опубликована: Сен. 6, 2017

T and B cells express most cholinergic system components-e.g., acetylcholine (ACh), choline acetyltransferase (ChAT), acetylcholinesterase, both muscarinic nicotinic ACh receptors (mAChRs nAChRs, respectively). Using ChATBAC-eGFP transgenic mice, ChAT expression has been confirmed in cells, dendritic macrophages. Moreover, cell activation via T-cell receptor/CD3-mediated pathways upregulates mRNA synthesis, suggesting that this lymphocytic contributes to the regulation of immune function. Immune all five mAChRs (M1-M5). Combined M1/M5 mAChR-deficient (M1/M5-KO) mice produce less antigen-specific antibody than wild-type (WT) mice. Furthermore, spleen M1/M5-KO tumor necrosis factor (TNF)-α interleukin (IL)-6, are involved regulating pro-inflammatory cytokine production. also frequently α2, α5, α6, α7, α9, α10 nAChR subunits. α7 nAChR-deficient (α7-KO) more WT from α7-KO TNF-α IL-6 cells. This suggests nAChRs production thus modulate Evidence indicates nicotine modulates responses by altering signaling immunomodulation through modification differentiation. Together, these findings suggest involvement The observation vagus nerve stimulation protects lethal endotoxin shock led notion a anti-inflammatory reflex pathway, is an essential component reflex. Because lacks direct innervation, it postulated synthesized subset CD4+ relays vagal signals on splenic macrophages, which downregulates synthesis release, thereby modulating inflammatory responses. However, because innervated solely noradrenergic nerve, confirmation pathway involving requires several hypotheses be addressed. We will review discuss issues context

Язык: Английский

Процитировано

316

Heart rate variability and inflammation: A meta-analysis of human studies DOI
DeWayne P. Williams, Julian Koenig, Luca Carnevali

и другие.

Brain Behavior and Immunity, Год журнала: 2019, Номер 80, С. 219 - 226

Опубликована: Март 11, 2019

Язык: Английский

Процитировано

290

Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture DOI Creative Commons
Shenbin Liu, Zhifu Wang,

Yang‐Shuai Su

и другие.

Neuron, Год журнала: 2020, Номер 108(3), С. 436 - 450.e7

Опубликована: Авг. 12, 2020

Язык: Английский

Процитировано

273