Annual Review of Neuroscience,
Год журнала:
2022,
Номер
45(1), С. 339 - 360
Опубликована: Апрель 1, 2022
Interactions
between
the
nervous
and
immune
systems
were
recognized
long
ago,
but
recent
studies
show
that
this
crosstalk
occurs
more
frequently
than
was
previously
appreciated.
Moreover,
technological
advances
have
enabled
identification
of
molecular
mediators
receptors
enable
interaction
these
two
complex
provide
new
insights
on
role
neuroimmune
in
organismal
physiology.
Most
interactions
occur
at
discrete
anatomical
locations
which
neurons
cells
colocalize.
Here,
we
describe
different
branches
peripheral
system
with
various
organs,
including
skin,
intestine,
lung,
adipose
tissue.
We
highlight
how
orchestrates
physiological
processes
such
as
host
defense,
tissue
repair,
metabolism,
thermogenesis.
Unraveling
intricate
relationships
is
invaluable
to
explore
therapeutic
potential
interactions.
Annual Review of Immunology,
Год журнала:
2018,
Номер
36(1), С. 783 - 812
Опубликована: Апрель 20, 2018
The
nervous
system
regulates
immunity
and
inflammation.
molecular
detection
of
pathogen
fragments,
cytokines,
other
immune
molecules
by
sensory
neurons
generates
immunoregulatory
responses
through
efferent
autonomic
neuron
signaling.
functional
organization
this
neural
control
is
based
on
principles
reflex
regulation.
Reflexes
involving
the
vagus
nerve
nerves
have
been
therapeutically
explored
in
models
inflammatory
autoimmune
conditions,
recently
clinical
settings.
brain
integrates
neuro-immune
communication,
function
altered
diseases
characterized
peripheral
dysregulation
Here
we
review
anatomical
basis
interface
with
immunity,
focusing
functions
role
model
immunological
homunculus.
Clinical
advances
stemming
from
knowledge
within
framework
bioelectronic
medicine
are
also
briefly
outlined.
Cell Reports,
Год журнала:
2019,
Номер
27(8), С. 2508 - 2523.e4
Опубликована: Май 1, 2019
Sensory
functions
of
the
vagus
nerve
are
critical
for
conscious
perceptions
and
monitoring
visceral
in
cardio-pulmonary
gastrointestinal
systems.
Here,
we
present
a
comprehensive
identification,
classification,
validation
neuron
types
neural
crest
(jugular)
placode
(nodose)
derived
vagal
ganglia
by
single-cell
RNA
sequencing
(scRNA-seq)
transcriptomic
analysis.
Our
results
reveal
major
differences
between
neurons
from
different
embryonic
origins.
Jugular
exhibit
fundamental
similarities
to
somatosensory
spinal
neurons,
including
types,
such
as
C-low
threshold
mechanoreceptors
(C-LTMRs),
A-LTMRs,
Aδ-nociceptors,
cold-,
mechano-heat
C-nociceptors.
In
contrast,
nodose
ganglion
contains
18
distinct
dedicated
surveying
physiological
state
internal
body.
vast
diversity
many
previously
unanticipated
well
proposed
that
consistent
with
chemoreceptors,
nutrient
detectors,
baroreceptors,
stretch
volume
respiratory,
gastrointestinal,
cardiovascular
Anesthesia & Analgesia,
Год журнала:
2019,
Номер
128(4), С. 781 - 788
Опубликована: Март 27, 2019
Neuroinflammation
has
become
a
key
hallmark
of
neurological
complications
including
perioperative
pathologies
such
as
postoperative
delirium
and
longer-lasting
cognitive
dysfunction.
Dysregulated
inflammation
neuronal
injury
are
emerging
from
clinical
studies
features
neurocognitive
disorders.
These
findings
paralleled
by
growing
body
preclinical
investigations
aimed
at
better
understanding
how
surgery
anesthesia
affect
the
central
nervous
system
possibly
contribute
to
decline.
Herein,
we
review
role
neuroinflammation
underlying
mechanisms
in
immune-to-brain
signaling
after
peripheral
surgery.
Frontiers in Immunology,
Год журнала:
2017,
Номер
8
Опубликована: Сен. 6, 2017
T
and
B
cells
express
most
cholinergic
system
components-e.g.,
acetylcholine
(ACh),
choline
acetyltransferase
(ChAT),
acetylcholinesterase,
both
muscarinic
nicotinic
ACh
receptors
(mAChRs
nAChRs,
respectively).
Using
ChATBAC-eGFP
transgenic
mice,
ChAT
expression
has
been
confirmed
in
cells,
dendritic
macrophages.
Moreover,
cell
activation
via
T-cell
receptor/CD3-mediated
pathways
upregulates
mRNA
synthesis,
suggesting
that
this
lymphocytic
contributes
to
the
regulation
of
immune
function.
Immune
all
five
mAChRs
(M1-M5).
Combined
M1/M5
mAChR-deficient
(M1/M5-KO)
mice
produce
less
antigen-specific
antibody
than
wild-type
(WT)
mice.
Furthermore,
spleen
M1/M5-KO
tumor
necrosis
factor
(TNF)-α
interleukin
(IL)-6,
are
involved
regulating
pro-inflammatory
cytokine
production.
also
frequently
α2,
α5,
α6,
α7,
α9,
α10
nAChR
subunits.
α7
nAChR-deficient
(α7-KO)
more
WT
from
α7-KO
TNF-α
IL-6
cells.
This
suggests
nAChRs
production
thus
modulate
Evidence
indicates
nicotine
modulates
responses
by
altering
signaling
immunomodulation
through
modification
differentiation.
Together,
these
findings
suggest
involvement
The
observation
vagus
nerve
stimulation
protects
lethal
endotoxin
shock
led
notion
a
anti-inflammatory
reflex
pathway,
is
an
essential
component
reflex.
Because
lacks
direct
innervation,
it
postulated
synthesized
subset
CD4+
relays
vagal
signals
on
splenic
macrophages,
which
downregulates
synthesis
release,
thereby
modulating
inflammatory
responses.
However,
because
innervated
solely
noradrenergic
nerve,
confirmation
pathway
involving
requires
several
hypotheses
be
addressed.
We
will
review
discuss
issues
context
