Communication dynamics in complex brain networks

Nature reviews. Neuroscience, Год журнала: 2017, Номер 19(1), С. 17 - 33

Опубликована: Дек. 14, 2017

Язык: Английский

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Linking Structure and Function in Macroscale Brain Networks

Trends in Cognitive Sciences, Год журнала: 2020, Номер 24(4), С. 302 - 315

Опубликована: Фев. 25, 2020

The emergence of network neuroscience allows researchers to quantify the link between organizational features neuronal networks and spectrum cortical functions.Current models indicate that structure function are significantly correlated, but correspondence is not perfect because reflects complex multisynaptic interactions in structural networks.Function cannot be directly estimated from structure, must inferred by higher-order interactions. Statistical, communication, biophysical have been used translate brain function.Structure–function coupling regionally heterogeneous follows molecular, cytoarchitectonic, functional hierarchies. Structure–function relationships a fundamental principle many naturally occurring systems. However, research suggests there an imperfect connectivity brain. Here, we synthesize current state knowledge linking macroscale discuss different types assess this relationship. We argue do include requisite biological detail completely predict function. Structural reconstructions enriched with local molecular cellular metadata, concert more nuanced representations functions properties, hold great potential for truly multiscale understanding structure–function relationship central concept natural sciences engineering. Consider how conformation protein determines its chemical properties and, ultimately, folding into 3D promotes among amino acids, allowing chemically interact other molecules endowing it Conversely, disruption protein's results loss Tellingly, said denatured, highlighting idea changing has fundamentally altered nervous system analogously shaped arrangement neurons populations. synaptic projections forms hierarchy (see Glossary) nested increasingly polyfunctional neural circuits support perception, cognition, action. Modern imaging technology permits high-throughput reconstruction across spatiotemporal scales species (Box 1). 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Язык: Английский

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Questions and controversies in the study of time-varying functional connectivity in resting fMRI

Network Neuroscience, Год журнала: 2019, Номер 4(1), С. 30 - 69

Опубликована: Дек. 16, 2019

The brain is a complex, multiscale dynamical system composed of many interacting regions. Knowledge the spatiotemporal organization these interactions critical for establishing solid understanding brain's functional architecture and relationship between neural dynamics cognition in health disease. possibility studying through careful analysis neuroimaging data has catalyzed substantial interest methods that estimate time-resolved fluctuations connectivity (often referred to as "dynamic" or time-varying connectivity; TVFC). At same time, debates have emerged regarding application TVFC analyses resting fMRI data, about statistical validity, physiological origins, cognitive behavioral relevance TVFC. These other unresolved issues complicate interpretation findings limit insights can be gained from this promising new research area. This article brings together scientists with variety perspectives on review current literature light issues. We introduce core concepts, define key terms, summarize controversies open questions, present forward-looking perspective how rigorously productively applied investigate wide range questions systems neuroscience.

Язык: Английский

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Human cognition involves the dynamic integration of neural activity and neuromodulatory systems

Nature Neuroscience, Год журнала: 2019, Номер 22(2), С. 289 - 296

Опубликована: Янв. 12, 2019

Язык: Английский

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The dynamics of resting fluctuations in the brain: metastability and its dynamical cortical core

Scientific Reports, Год журнала: 2017, Номер 7(1)

Опубликована: Июнь 2, 2017

In the human brain, spontaneous activity during resting state consists of rapid transitions between functional network states over time but underlying mechanisms are not understood. We use connectome based computational brain modeling to reveal fundamental principles how generates large-scale observable by noninvasive neuroimaging. used structural and neuroimaging data construct whole- models. With this novel approach, we that operates at maximum metastability, i.e. in a switching. addition, investigate cortical heterogeneity across areas. Optimization spectral characteristics each local region revealed dynamical core which is driving rest whole brain. Brain modelling goes beyond correlational analysis reveals non-trivial non-invasive observations. Our findings significantly pertain important role connectomics understanding function.

Язык: Английский

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Colloquium: Criticality and dynamical scaling in living systems

Reviews of Modern Physics, Год журнала: 2018, Номер 90(3)

Опубликована: Июль 10, 2018

A celebrated and controversial hypothesis conjectures that some biological systems --parts, aspects, or groups of them-- may extract important functional benefits from operating at the edge instability, halfway between order disorder, i.e. in vicinity critical point a phase transition. Criticality has been argued to provide with an optimal balance robustness against perturbations flexibility adapt changing conditions, as well confer on them computational capabilities, huge dynamical repertoires, unparalleled sensitivity stimuli, etc. Criticality, its concomitant scale invariance, can be conjectured emerge living result adaptive evolutionary processes that, for reasons fully elucidated, select it template upon which higher layers complexity rest. This is very suggestive proposes criticality could constitute general common organizing strategy biology stemming physics transitions. However, despite thrilling implications, this still embryonic state well-founded theory and, such, elicited healthy skepticism. From experimental side, advent high-throughput technologies created new prospects exploration systems, empirical evidence favor proliferated, examples ranging endogenous brain activity gene-expression patterns, flocks birds insect-colony foraging, name but few...

Язык: Английский

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Gradients of structure–function tethering across neocortex

Proceedings of the National Academy of Sciences, Год журнала: 2019, Номер 116(42), С. 21219 - 21227

Опубликована: Сен. 30, 2019

The white matter architecture of the brain imparts a distinct signature on neuronal coactivation patterns. Interregional projections promote synchrony among distant populations, giving rise to richly patterned functional networks. A variety statistical, communication, and biophysical models have been proposed study relationship between structure function, but link is not yet known. In present report we seek relate structural connection profiles individual areas. We apply simple multilinear model that incorporates information about spatial proximity, routing, diffusion regions predict their connectivity. find structure–function relationships vary markedly across neocortex. Structure function correspond closely in unimodal, primary sensory, motor regions, diverge transmodal cortex, particularly default mode salience divergence systematically follows cytoarchitectonic hierarchies. Altogether, results demonstrate networks do align uniformly brain, gradually uncouple higher-order polysensory

Язык: Английский

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Dopamine and glutamate in schizophrenia: biology, symptoms and treatment

World Psychiatry, Год журнала: 2020, Номер 19(1), С. 15 - 33

Опубликована: Янв. 10, 2020

Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both have been proposed to contribute significantly the pathophysiology schizophrenia. In this paper we assess research that has implicated aetiology disorder. We examine evidence from post‐mortem, preclinical, pharmacological vivo neuroimaging studies. Pharmacological preclinical studies implicate systems, imaging system consistently identified elevated striatal synthesis release capacity Imaging glutamate other aspects on produced less consistent findings, potentially due methodological limitations heterogeneity Converging indicates genetic environmental risk factors for schizophrenia underlie disruption glutamatergic dopaminergic function. However, while influences may directly dysfunction, few variants system, indicating aberrant signalling is likely be predominantly factors. discuss neural circuits through which two interact, how their cause psychotic symptoms. also mechanisms existing treatments operate, recent highlighted opportunities development novel therapies. Finally, consider outstanding questions field, including what remains unknown regarding nature function schizophrenia, needs achieved make progress developing new treatments.

Язык: Английский

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Human consciousness is supported by dynamic complex patterns of brain signal coordination

Science Advances, Год журнала: 2019, Номер 5(2)

Опубликована: Фев. 1, 2019

Dynamic patterns of brain activity at rest distinguish conscious and unconscious states in humans.

Язык: Английский

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On the nature and use of models in network neuroscience

Nature reviews. Neuroscience, Год журнала: 2018, Номер 19(9), С. 566 - 578

Опубликована: Июль 12, 2018

Язык: Английский

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