Synaptic mechanisms underlying persistent cocaine craving

Nature reviews. Neuroscience, Год журнала: 2016, Номер 17(6), С. 351 - 365

Опубликована: Май 6, 2016

Язык: Английский

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ERK2: a logical AND gate critical for drug-induced plasticity?

Current Opinion in Pharmacology, Год журнала: 2006, Номер 7(1), С. 77 - 85

Опубликована: Ноя. 8, 2006

Язык: Английский

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Upregulation of Voluntary Alcohol Intake, Behavioral Sensitivity to Stress, and Amygdala Crhr1 Expression Following a History of Dependence

Biological Psychiatry, Год журнала: 2007, Номер 63(2), С. 139 - 145

Опубликована: Июнь 22, 2007

Язык: Английский

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Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories – indications for novel treatments of addiction

European Journal of Neuroscience, Год журнала: 2014, Номер 40(1), С. 2163 - 2182

Опубликована: Июнь 17, 2014

Abstract This review discusses the evidence for hypothesis that development of drug addiction can be understood in terms interactions between Pavlovian and instrumental learning memory mechanisms brain underlie seeking taking drugs. It is argued these behaviours initially are goal‐directed, but increasingly become elicited as stimulus–response habits by drug‐associated conditioned stimuli established conditioning. further compulsive use emerges result a loss prefrontal cortical inhibitory control over habits. Data reviewed indicate transitions from to abuse depend upon shifts ventral dorsal striatal behaviour, mediated part serial connectivity striatum midbrain dopamine systems. Only some individuals lose their use, importance behavioural impulsivity vulnerability trait predicting stimulant animals humans, together with consideration an emerging neuroendophenotype discussed. Finally, potential developing treatments considered light neuropsychological advances reviewed, including possibility targeting reconsolidation extinction reduce influences on means promoting abstinence preventing relapse.

Язык: Английский

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AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine

Neuroscience & Biobehavioral Reviews, Год журнала: 2010, Номер 35(2), С. 185 - 211

Опубликована: Янв. 29, 2010

Язык: Английский

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The persistence of maladaptive memory: Addiction, drug memories and anti-relapse treatments

Neuroscience & Biobehavioral Reviews, Год журнала: 2012, Номер 36(4), С. 1119 - 1139

Опубликована: Янв. 29, 2012

Язык: Английский

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‘Liking’ and ‘wanting’ in eating and food reward: Brain mechanisms and clinical implications

Physiology & Behavior, Год журнала: 2020, Номер 227, С. 113152 - 113152

Опубликована: Авг. 23, 2020

Язык: Английский

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Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference

Proceedings of the National Academy of Sciences, Год журнала: 2006, Номер 103(8), С. 2932 - 2937

Опубликована: Фев. 10, 2006

Repeated association of drugs abuse with context leads to long-lasting behavioral responses that reflect reward-controlled learning and participate in the establishment addiction. Reactivation consolidated memories is known produce a reconsolidation process during which undergo labile state. We investigated whether reexposure had similar effects. Cocaine administration activates extracellular signal-regulated kinase (ERK) striatum, ERK activation required for acquisition cocaine-induced conditioned place preference (CPP). When mice previously cocaine-place were reexposed cocaine drug-paired compartment after systemic SL327, an inhibitor activation, CPP response was abolished 24 h later. This procedure also phosphorylation glutamate receptor-1 observed ventral dorsal later, test. Erasure by SL327 combination did not result from enhanced extinction. Similarly, morphine presence long-lastingly learned morphine-CPP. The effects on cocaine- or morphine-CPP reproduced protein synthesis inhibition. In contrast, inhibition alter acquired locomotor sensitization cocaine. Our findings show established can be disrupted when reactivation associates both drug administration. involves ERK, treatment preventing erases response. These results suggest potential therapeutic strategies explore

Язык: Английский

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Cue-Induced Cocaine Seeking and Relapse Are Reduced by Disruption of Drug Memory Reconsolidation

Journal of Neuroscience, Год журнала: 2006, Номер 26(22), С. 5881 - 5887

Опубликована: Май 31, 2006

Long-lasting vulnerability to drug cue-induced relapse a drug-taking habit is major challenge the treatment of addiction. Here we show that blockade memory reconsolidation, through infusion Zif268 antisense oligodeoxynucleotides into basolateral amygdala shortly before reexposure cocaine-associated stimulus but not simply training context, severely impaired subsequently cue-maintained cocaine seeking under second-order schedule reinforcement and abolished reinstatement seeking. This reduction in after disrupted reconsolidation was only seen several hundred pairings with self-administered cocaine, older, as well recent, memories were also disrupted. Reconsolidation may thus provide potential therapeutic strategy for prevention

Язык: Английский

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Role of ERK in cocaine addiction

Trends in Neurosciences, Год журнала: 2006, Номер 29(12), С. 695 - 703

Опубликована: Ноя. 8, 2006

Язык: Английский

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