Biological Psychiatry, Год журнала: 2010, Номер 69(7), С. 708 - 711
Опубликована: Сен. 4, 2010
Язык: Английский
Biological Psychiatry, Год журнала: 2010, Номер 69(7), С. 708 - 711
Опубликована: Сен. 4, 2010
Язык: Английский
Nature reviews. Neuroscience, Год журнала: 2016, Номер 17(6), С. 351 - 365
Опубликована: Май 6, 2016
Язык: Английский
Процитировано
366Current Opinion in Pharmacology, Год журнала: 2006, Номер 7(1), С. 77 - 85
Опубликована: Ноя. 8, 2006
Язык: Английский
Процитировано
339Biological Psychiatry, Год журнала: 2007, Номер 63(2), С. 139 - 145
Опубликована: Июнь 22, 2007
Язык: Английский
Процитировано
316European Journal of Neuroscience, Год журнала: 2014, Номер 40(1), С. 2163 - 2182
Опубликована: Июнь 17, 2014
Abstract This review discusses the evidence for hypothesis that development of drug addiction can be understood in terms interactions between Pavlovian and instrumental learning memory mechanisms brain underlie seeking taking drugs. It is argued these behaviours initially are goal‐directed, but increasingly become elicited as stimulus–response habits by drug‐associated conditioned stimuli established conditioning. further compulsive use emerges result a loss prefrontal cortical inhibitory control over habits. Data reviewed indicate transitions from to abuse depend upon shifts ventral dorsal striatal behaviour, mediated part serial connectivity striatum midbrain dopamine systems. Only some individuals lose their use, importance behavioural impulsivity vulnerability trait predicting stimulant animals humans, together with consideration an emerging neuroendophenotype discussed. Finally, potential developing treatments considered light neuropsychological advances reviewed, including possibility targeting reconsolidation extinction reduce influences on means promoting abstinence preventing relapse.
Язык: Английский
Процитировано
295Neuroscience & Biobehavioral Reviews, Год журнала: 2010, Номер 35(2), С. 185 - 211
Опубликована: Янв. 29, 2010
Язык: Английский
Процитировано
266Neuroscience & Biobehavioral Reviews, Год журнала: 2012, Номер 36(4), С. 1119 - 1139
Опубликована: Янв. 29, 2012
Язык: Английский
Процитировано
256Physiology & Behavior, Год журнала: 2020, Номер 227, С. 113152 - 113152
Опубликована: Авг. 23, 2020
Язык: Английский
Процитировано
238Proceedings of the National Academy of Sciences, Год журнала: 2006, Номер 103(8), С. 2932 - 2937
Опубликована: Фев. 10, 2006
Repeated association of drugs abuse with context leads to long-lasting behavioral responses that reflect reward-controlled learning and participate in the establishment addiction. Reactivation consolidated memories is known produce a reconsolidation process during which undergo labile state. We investigated whether reexposure had similar effects. Cocaine administration activates extracellular signal-regulated kinase (ERK) striatum, ERK activation required for acquisition cocaine-induced conditioned place preference (CPP). When mice previously cocaine-place were reexposed cocaine drug-paired compartment after systemic SL327, an inhibitor activation, CPP response was abolished 24 h later. This procedure also phosphorylation glutamate receptor-1 observed ventral dorsal later, test. Erasure by SL327 combination did not result from enhanced extinction. Similarly, morphine presence long-lastingly learned morphine-CPP. The effects on cocaine- or morphine-CPP reproduced protein synthesis inhibition. In contrast, inhibition alter acquired locomotor sensitization cocaine. Our findings show established can be disrupted when reactivation associates both drug administration. involves ERK, treatment preventing erases response. These results suggest potential therapeutic strategies explore
Язык: Английский
Процитировано
295Journal of Neuroscience, Год журнала: 2006, Номер 26(22), С. 5881 - 5887
Опубликована: Май 31, 2006
Long-lasting vulnerability to drug cue-induced relapse a drug-taking habit is major challenge the treatment of addiction. Here we show that blockade memory reconsolidation, through infusion Zif268 antisense oligodeoxynucleotides into basolateral amygdala shortly before reexposure cocaine-associated stimulus but not simply training context, severely impaired subsequently cue-maintained cocaine seeking under second-order schedule reinforcement and abolished reinstatement seeking. This reduction in after disrupted reconsolidation was only seen several hundred pairings with self-administered cocaine, older, as well recent, memories were also disrupted. Reconsolidation may thus provide potential therapeutic strategy for prevention
Язык: Английский
Процитировано
289Trends in Neurosciences, Год журнала: 2006, Номер 29(12), С. 695 - 703
Опубликована: Ноя. 8, 2006
Язык: Английский
Процитировано
279