Sleep deprivation, vigilant attention, and brain function: a review

Neuropsychopharmacology, Год журнала: 2019, Номер 45(1), С. 21 - 30

Опубликована: Июнь 8, 2019

Язык: Английский

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Arousal and sleep circuits

Neuropsychopharmacology, Год журнала: 2019, Номер 45(1), С. 6 - 20

Опубликована: Июнь 19, 2019

Язык: Английский

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Sleep Deprivation and Neurological Disorders

BioMed Research International, Год журнала: 2020, Номер 2020, С. 1 - 19

Опубликована: Ноя. 23, 2020

Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health wellbeing. deprivation (SD) disturbs the circadian physiology exerts a negative impact on brain behavioural functions. SD impairs cellular clearance of misfolded neurotoxin proteins like α-synuclein, amyloid-β, tau which are involved major neurodegenerative diseases Alzheimer's disease Parkinson's disease. In addition, is also shown to affect glymphatic system, glial-dependent metabolic waste pathway, causing accumulation faulty synaptic compartments resulting cognitive decline. Also, affects immunological redox system neuroinflammation oxidative stress. Hence, it understand molecular biochemical alterations that causative factors leading these pathophysiological effects system. This review attempt this direction. It provides up-to-date information key processes, pathways, negatively affected by become reasons for neurological disorders over prolonged period time, if left unattended.

Язык: Английский

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Rising temperatures erode human sleep globally

One Earth, Год журнала: 2022, Номер 5(5), С. 534 - 549

Опубликована: Май 1, 2022

Язык: Английский

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A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals

Nature Biomedical Engineering, Год журнала: 2023, Номер 7(10), С. 1252 - 1269

Опубликована: Апрель 27, 2023

Язык: Английский

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Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder

Translational Psychiatry, Год журнала: 2023, Номер 13(1)

Опубликована: Июнь 26, 2023

The pathophysiology of major depressive disorder (MDD) is thought to result from impaired connectivity between key brain networks. Gamma-aminobutyric acid (GABA) the inhibitory neurotransmitter in brain, working primarily via GABA

Язык: Английский

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The Microbiota–Gut–Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review

Nutrients, Год журнала: 2024, Номер 16(3), С. 390 - 390

Опубликована: Янв. 29, 2024

Background: Over recent decades, a growing body of evidence has emerged linking the composition gut microbiota to sleep regulation. Interestingly, prevalence disorders is commonly related cardiometabolic comorbidities such as diabetes, impaired lipid metabolism, and metabolic syndrome (MetS). In this complex scenario, role gut–brain axis main communicating pathway between regulation pathways in brain reveals some common host–microbial biomarkers both disturbances MetS. As biological mechanisms behind interacting network neuroendocrine, immune, are not fully understood yet, present systematic review aims describe microbial features these two unrelated chronic conditions. Results: This highlights total 36 articles associating signature with MetS or disorders. Specific emphasis given studies evaluating effect dietary patterns, supplementation, probiotics on disturbances. Conclusions: Dietary choices promote metabolites, causing amelioration impairment homeostasis.

Язык: Английский

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Sleep Disturbance and Pain

CHEST Journal, Год журнала: 2018, Номер 154(5), С. 1249 - 1259

Опубликована: Июль 27, 2018

Язык: Английский

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Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Март 5, 2019

Abstract Sleep is essential to all animals with a nervous system. Nevertheless, the core cellular function of sleep unknown, and there no conserved molecular marker define across phylogeny. Time-lapse imaging chromosomal markers in single cells live zebrafish revealed that increases chromosome dynamics individual neurons but not two other cell types. Manipulation sleep, dynamics, neuronal activity, DNA double-strand breaks (DSBs) showed are low number DSBs accumulates during wakefulness. In turn, which necessary reduce amount DSBs. These results establish as potential sleeping cells, propose restorative nuclear maintenance.

Язык: Английский

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Molecular Mechanisms of Cancer-Induced Sleep Disruption

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(11), С. 2780 - 2780

Опубликована: Июнь 6, 2019

Sleep is essential for health. Indeed, poor sleep consistently linked to the development of systemic disease, including depression, metabolic syndrome, and cognitive impairments. Further evidence has accumulated suggesting role in cancer initiation progression (primarily breast cancer). patients with survivors frequently experience sleep, manifesting as insomnia, circadian misalignment, hypersomnia, somnolence hot flushes, nightmares. These problems are associated a reduction patients’ quality life increased mortality. Due heterogeneity among cancers, treatment regimens, patient populations lifestyle factors, etiology cancer-induced disruption largely unknown. Here, we discuss recent advances understanding pathways linking brain how this leads altered patterns. We describe conceptual framework where tumors disrupt normal homeostatic processes, resulting aberrant changes physiology behavior that detrimental Finally, knowledge can be leveraged develop novel therapeutic approaches cancer-associated disruption, special emphasis on host-tumor interactions.

Язык: Английский

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