Therapeutically harnessing extracellular vesicles

Nature Reviews Drug Discovery, Год журнала: 2022, Номер 21(5), С. 379 - 399

Опубликована: Март 2, 2022

Язык: Английский

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Long noncoding RNAs in cancer metastasis

Nature reviews. Cancer, Год журнала: 2021, Номер 21(7), С. 446 - 460

Опубликована: Май 5, 2021

Язык: Английский

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Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

Pharmaceutics, Год журнала: 2018, Номер 10(4), С. 218 - 218

Опубликована: Ноя. 6, 2018

The similarities between exosomes and liposomes, together with the high organotropism of several types exosomes, have recently prompted development engineered-exosomes or exosome-mimetics, which may be artificial (liposomal) cell-derived vesicles, as advanced platforms for targeted drug delivery. Here, we provide current state-of-the-art using exosome exosome-inspired systems We review various approaches investigated shortcomings each approach. Finally challenges been identified to date in this field are summarized.

Язык: Английский

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Aptamer-Based Detection of Circulating Targets for Precision Medicine

Chemical Reviews, Год журнала: 2021, Номер 121(19), С. 12035 - 12105

Опубликована: Март 5, 2021

The past decade has witnessed ongoing progress in precision medicine to improve human health. As an emerging diagnostic technique, liquid biopsy can provide real-time, comprehensive, dynamic physiological and pathological information a noninvasive manner, opening new window for medicine. Liquid depends on the sensitive reliable detection of circulating targets (e.g., cells, extracellular vesicles, proteins, microRNAs) from body fluids, performance which is largely governed by recognition ligands. Aptamers are single-stranded functional oligonucleotides, capable folding into unique tertiary structures bind their with superior specificity affinity. Their mature evolution procedure, facile modification, affinity regulation, as well versatile structural design engineering, make aptamers ideal ligands biopsy. In this review, we present broad overview aptamer-based techniques We begin recent advances aptamer selection, followed summary state-of-the-art strategies multivalent assembly interface modification. will further describe micro-/nanoisolation platforms, aptamer-enabled release methods, aptamer-assisted signal amplification strategies. Finally, our perspectives regarding opportunities challenges

Язык: Английский

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The extracellular matrix in tumor progression and metastasis

Clinical & Experimental Metastasis, Год журнала: 2019, Номер 36(3), С. 171 - 198

Опубликована: Апрель 11, 2019

Язык: Английский

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