Sexual Dimorphism in Colon Cancer DOI Creative Commons

Maria Abancens,

Viviana Bustos,

Harry Harvey

и другие.

Frontiers in Oncology, Год журнала: 2020, Номер 10

Опубликована: Дек. 9, 2020

A higher incidence of colorectal cancer (CRC) is found in males compared to females. Young women (18-44 years) with CRC have a better survival outcome men the same age or older (over 50 years), indicating global sexual dimorphism rates and survival. This suggests protective role for sex steroid hormone estrogen development. Key proliferative pathways tumorigenesis exhibit dimorphism, which confer females through regulated genes cell signaling. Estrogen regulates activity class Kv channels (KCNQ1:KCNE3), control fundamental ion transport functions colon epithelial mesenchymal transition bi-directional interactions Wnt/β-catenin signalling pathway. also modulates responses hypoxia

Язык: Английский

The Molecular Hallmarks of the Serrated Pathway in Colorectal Cancer DOI Open Access
Fatima Domenica Elisa De Palma, Valeria D’Argenio, Jonathan Pol

и другие.

Cancers, Год журнала: 2019, Номер 11(7), С. 1017 - 1017

Опубликована: Июль 20, 2019

Colorectal cancer (CRC) is a leading cause of death worldwide. It includes different subtypes that differ in their clinical and prognostic features. In the past decade, addition to conventional adenoma-carcinoma model, an alternative multistep mechanism carcinogenesis, namely "serrated pathway", has been described. Approximately, 15 30% all CRCs arise from neoplastic serrated polyps, heterogeneous group lesions are histologically classified into three morphologic categories: hyperplastic sessile adenomas/polyps, traditional adenomas/polyps. Serrated polyps characterized by genetic (BRAF or KRAS mutations) epigenetic (CpG island methylator phenotype (CIMP)) alterations cooperate initiate drive malignant transformation normal colon mucosa then CRC. The high heterogeneity renders diagnostic pathological interpretation difficult. Hence, novel biomarkers required for better classification management CRCs. To date, several molecular have associated with polyp-CRC sequence. addition, gut microbiota emerging as contributor to/modulator pathway. This review summarizes state art genetic, signatures CRCs, together implications.

Язык: Английский

Процитировано

164

Circular RNAs and gastrointestinal cancers: Epigenetic regulators with a prognostic and therapeutic role DOI

Parisa Naeli,

Mohammad Hossein Pourhanifeh, Mohammad Reza Karimzadeh

и другие.

Critical Reviews in Oncology/Hematology, Год журнала: 2019, Номер 145, С. 102854 - 102854

Опубликована: Дек. 20, 2019

Язык: Английский

Процитировано

151

FGFR2 Promotes Expression of PD-L1 in Colorectal Cancer via the JAK/STAT3 Signaling Pathway DOI Open Access
Piao Li, Tingting Huang, Qi Zou

и другие.

The Journal of Immunology, Год журнала: 2019, Номер 202(10), С. 3065 - 3075

Опубликована: Апрель 12, 2019

Although multidisciplinary treatment is widely applied in colorectal cancer (CRC), the prognosis of patients with advanced CRC remains poor. Immunotherapy blocking programmed cell death ligand 1 (PD-L1) a promising approach. Binding transmembrane protein PD-L1 expressed by tumor cells or microenvironment to its receptor (PD-1) induces immunosuppressive signals and reduces proliferation T cells, which an important mechanism immune escape key issue immunotherapy. However, regulation expression poorly understood CRC. Fibroblast growth factor (FGF) (FGFR) 2 causes tyrosine kinase domains initiate cascade intracellular binding FGFs dimerization (pairing receptors), involved tumorigenesis progression. In this study, we showed that FGFR2 were frequently overexpressed CRC, was significantly associated lymph node metastasis, clinical stage, poor survival. current positively correlated Tumor-derived-activated induced via JAK/STAT3 signaling pathway human (SW480 NCI-H716), apoptosis Jurkat cells. also promoted xenograft mouse model The results our study reveal novel thus providing theoretical basis for reversing tolerance overexpression

Язык: Английский

Процитировано

150

Young-onset colorectal cancer DOI
Manon C.W. Spaander, Ann G. Zauber, Sapna Syngal

и другие.

Nature Reviews Disease Primers, Год журнала: 2023, Номер 9(1)

Опубликована: Апрель 27, 2023

Язык: Английский

Процитировано

148

Sexual Dimorphism in Colon Cancer DOI Creative Commons

Maria Abancens,

Viviana Bustos,

Harry Harvey

и другие.

Frontiers in Oncology, Год журнала: 2020, Номер 10

Опубликована: Дек. 9, 2020

A higher incidence of colorectal cancer (CRC) is found in males compared to females. Young women (18-44 years) with CRC have a better survival outcome men the same age or older (over 50 years), indicating global sexual dimorphism rates and survival. This suggests protective role for sex steroid hormone estrogen development. Key proliferative pathways tumorigenesis exhibit dimorphism, which confer females through regulated genes cell signaling. Estrogen regulates activity class Kv channels (KCNQ1:KCNE3), control fundamental ion transport functions colon epithelial mesenchymal transition bi-directional interactions Wnt/β-catenin signalling pathway. also modulates responses hypoxia

Язык: Английский

Процитировано

147