Genes & Development,
Год журнала:
2012,
Номер
26(7), С. 657 - 667
Опубликована: Апрель 1, 2012
The
nuclear
receptor
Rev-erbα
regulates
circadian
rhythm
and
metabolism,
but
its
effects
are
modest
it
has
been
considered
to
be
a
secondary
regulator
of
the
cell-autonomous
clock.
Here
we
report
that
depletion
together
with
closely
related
Rev-erbβ
dramatic
on
clock
as
well
hepatic
lipid
metabolism.
Mouse
embryonic
fibroblasts
were
rendered
arrhythmic
by
both
Rev-erbs.
In
mouse
livers,
mRNA
protein
levels
oscillate
diurnal
pattern
similar
Rev-erbα,
Rev-erbs
recruited
remarkably
set
binding
sites
across
genome,
enriched
near
metabolic
genes.
Depletion
in
liver
synergistically
derepresses
several
genes
control
positive
limb
molecular
Moreover,
deficiency
causes
marked
steatosis,
contrast
relatively
subtle
changes
upon
loss
either
subtype
alone.
These
findings
establish
two
major
regulators
function
displaying
level
collaboration
is
unusual
among
receptors
common
core
proteins,
protecting
organism
from
perturbations
physiology.
Proceedings of the National Academy of Sciences,
Год журнала:
2013,
Номер
110(12)
Опубликована: Фев. 25, 2013
Significance
Insufficient
sleep
and
circadian
rhythm
disruption
are
associated
with
negative
health
outcomes,
but
the
mechanisms
involved
remain
largely
unexplored.
We
show
that
one
wk
of
insufficient
alters
gene
expression
in
human
blood
cells,
reduces
amplitude
rhythms
expression,
intensifies
effects
subsequent
acute
total
loss
on
expression.
The
affected
genes
chromatin
remodeling,
regulation
immune
stress
responses.
data
imply
molecular
mediating
highlight
interrelationships
between
homeostasis,
rhythmicity,
metabolism.
International Review of Psychiatry,
Год журнала:
2014,
Номер
26(2), С. 139 - 154
Опубликована: Апрель 1, 2014
Circadian
rhythms
are
near
24-h
patterns
of
physiology
and
behaviour
that
present
independent
external
cues
including
hormones,
body
temperature,
mood,
sleep
propensity.
The
term
'circadian
misalignment'
describes
a
variety
circumstances,
such
as
inappropriately
timed
wake,
misalignment
sleep/wake
with
feeding
rhythms,
or
misaligned
central
peripheral
rhythms.
predominance
early
research
focused
on
to
the
biological
night.
However,
discovery
clock
genes
presence
circadian
oscillators
have
expanded
definitions
misalignment.
Experimental
studies
conducted
in
animal
models
humans
provided
evidence
potential
mechanisms
link
negative
outcomes.
These
include
dysregulation
behaviours,
changes
appetite
stimulating
glucose
metabolism
mood.
This
review
has
two
foci:
(1)
describe
how
been
defined
evaluated
laboratory
field
experiments,
(2)
linking
different
types
increased
risk
for
physical
(cardiovascular
disease,
diabetes,
obesity,
cancer)
psychiatric
(depression,
bipolar,
schizophrenia,
attention
deficit)
disorders.
will
role
factor
disease
general
population
clinical
populations,
rhythm
disorders
Genes & Development,
Год журнала:
2012,
Номер
26(7), С. 657 - 667
Опубликована: Апрель 1, 2012
The
nuclear
receptor
Rev-erbα
regulates
circadian
rhythm
and
metabolism,
but
its
effects
are
modest
it
has
been
considered
to
be
a
secondary
regulator
of
the
cell-autonomous
clock.
Here
we
report
that
depletion
together
with
closely
related
Rev-erbβ
dramatic
on
clock
as
well
hepatic
lipid
metabolism.
Mouse
embryonic
fibroblasts
were
rendered
arrhythmic
by
both
Rev-erbs.
In
mouse
livers,
mRNA
protein
levels
oscillate
diurnal
pattern
similar
Rev-erbα,
Rev-erbs
recruited
remarkably
set
binding
sites
across
genome,
enriched
near
metabolic
genes.
Depletion
in
liver
synergistically
derepresses
several
genes
control
positive
limb
molecular
Moreover,
deficiency
causes
marked
steatosis,
contrast
relatively
subtle
changes
upon
loss
either
subtype
alone.
These
findings
establish
two
major
regulators
function
displaying
level
collaboration
is
unusual
among
receptors
common
core
proteins,
protecting
organism
from
perturbations
physiology.
