Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Skin Pharmacology and Physiology, Год журнала: 2016, Номер 29(4), С. 190 - 203

Опубликована: Янв. 1, 2016

Collagen and elastin networks make up the majority of extracellular matrix in many organs, such as skin. The mechanisms which are involved maintenance homeostatic equilibrium these numerous, involving regulation genetic expression, growth factor secretion, signalling pathways, secondary messaging systems, ion channel activity. However, factors capable disrupting leads to an imbalance equilibrium. Ultimately, this changes physical nature skin, both functionally cosmetically. Although various have been identified, including carcinogenesis, ultraviolet exposure, mechanical stretching it was discovered that them affect similar components regulatory fibroblasts, lysyl oxidase, fibronectin. Additionally, pathways intersect with each other at stages instead working independently other. This review paper proposes a model elucidates how molecular one another, internal external can disrupt ultimately leading disruption collagen networks.

Язык: Английский

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Concepts of extracellular matrix remodelling in tumour progression and metastasis

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Окт. 9, 2020

Abstract Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions ECM remodelling. Tumours leverage remodelling to create a microenvironment that promotes tumourigenesis metastasis. In this review, we focus on how tumour tumour-associated stromal deposit, biochemically biophysically modify, degrade ECM. These tumour-driven changes support growth, increase migration of cells, remodel in distant organs allow for metastatic progression. A better understanding underlying mechanisms tumourigenic is crucial developing therapeutic treatments patients.

Язык: Английский

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Effects of extracellular matrix viscoelasticity on cellular behaviour

Nature, Год журнала: 2020, Номер 584(7822), С. 535 - 546

Опубликована: Авг. 26, 2020

Язык: Английский

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Extracellular matrix assembly: a multiscale deconstruction

Nature Reviews Molecular Cell Biology, Год журнала: 2014, Номер 15(12), С. 771 - 785

Опубликована: Ноя. 5, 2014

Язык: Английский

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Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores

Cell, Год журнала: 2017, Номер 171(6), С. 1397 - 1410.e14

Опубликована: Окт. 26, 2017

Язык: Английский

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Mechanobiology of YAP and TAZ in physiology and disease

Nature Reviews Molecular Cell Biology, Год журнала: 2017, Номер 18(12), С. 758 - 770

Опубликована: Сен. 27, 2017

Язык: Английский

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The Hippo Pathway: Biology and Pathophysiology

Annual Review of Biochemistry, Год журнала: 2018, Номер 88(1), С. 577 - 604

Опубликована: Дек. 19, 2018

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size control, regeneration. core the mammals consists kinase cascade, MST1/2 LATS1/2, well downstream effectors, transcriptional coactivators YAP TAZ. These components control programs involved proliferation, survival, mobility, stemness, differentiation. tightly regulated by both intrinsic extrinsic signals, such mechanical force, cell-cell contact, polarity, energy status, stress, many diffusible hormonal factors, majority which act through G protein-coupled receptors. Here, we review current understanding molecular mechanisms signals regulate with emphasis on mechanotransduction effects this basic biology human diseases.

Язык: Английский

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Advancing biomaterials of human origin for tissue engineering

Progress in Polymer Science, Год журнала: 2015, Номер 53, С. 86 - 168

Опубликована: Апрель 11, 2015

Язык: Английский

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The extracellular matrix: Tools and insights for the “omics” era

Matrix Biology, Год журнала: 2015, Номер 49, С. 10 - 24

Опубликована: Июль 8, 2015

The extracellular matrix (ECM) is a fundamental component of multicellular organisms that provides mechanical and chemical cues orchestrate cellular tissue organization functions. Degradation, hyperproduction or alteration the composition ECM cause accompany numerous pathologies. Thus, better characterization composition, metabolism, biology can lead to identification novel prognostic diagnostic markers therapeutic opportunities. development over last few years high-throughput (“omics”) approaches has considerably accelerated pace discovery in life sciences. In this review, we describe new bioinformatic tools experimental strategies for research, illustrate how these be exploited provide insights our understanding biology. We also introduce web platform “the matrisome project” database MatrisomeDB compiles silico vivo data on matrisome, defined as ensemble genes encoding ECM-associated proteins. Finally, present first draft an atlas built by compiling proteomics 14 different tissues tumor types.

Язык: Английский

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YAP/TAZ upstream signals and downstream responses

Nature Cell Biology, Год журнала: 2018, Номер 20(8), С. 888 - 899

Опубликована: Июль 19, 2018

Язык: Английский

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