Transcriptional architecture of the mammalian circadian clock

Nature Reviews Genetics, Год журнала: 2016, Номер 18(3), С. 164 - 179

Опубликована: Дек. 19, 2016

Язык: Английский

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Cohesin Loss Eliminates All Loop Domains

Cell, Год журнала: 2017, Номер 171(2), С. 305 - 320.e24

Опубликована: Окт. 1, 2017

Язык: Английский

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Transcriptional Addiction in Cancer

Cell, Год журнала: 2017, Номер 168(4), С. 629 - 643

Опубликована: Фев. 1, 2017

Язык: Английский

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Organizational principles of 3D genome architecture

Nature Reviews Genetics, Год журнала: 2018, Номер 19(12), С. 789 - 800

Опубликована: Окт. 26, 2018

Язык: Английский

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Histone exchange, chromatin structure and the regulation of transcription

Nature Reviews Molecular Cell Biology, Год журнала: 2015, Номер 16(3), С. 178 - 189

Опубликована: Фев. 4, 2015

Язык: Английский

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BRD4 and Cancer: going beyond transcriptional regulation

Molecular Cancer, Год журнала: 2018, Номер 17(1)

Опубликована: Ноя. 22, 2018

BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role super-enhancers (SEs) organization oncogenes expression regulation. Inhibition BRD4 shortcuts communication between SEs target promoters with a subsequent cell-specific repression to which cells are addicted cell death. To date, this most credited mechanism action BET inhibitors, class small molecules targeting proteins currently clinical trials several settings. However, recent evidence indicates that relevance goes beyond transcription regulation identifies as keeper genome stability. Indeed, non-transcriptional controlling DNA damage checkpoint activation repair well telomere maintenance has been proposed, throwing new lights into multiple functions opening perspectives on use BETi cancer. Here we discuss current available information non-canonical, their implications biology. Integrating already known gene regulation, propose "common" model explain genomic function. Furthermore, light transversal function provide interpretation cytotoxic activity possibilities wide focused employment these drugs

Язык: Английский

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Genomic encoding of transcriptional burst kinetics

Nature, Год журнала: 2018, Номер 565(7738), С. 251 - 254

Опубликована: Дек. 21, 2018

Язык: Английский

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Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation

Genes & Development, Год журнала: 2019, Номер 33(15-16), С. 960 - 982

Опубликована: Май 23, 2019

Precise spatio-temporal control of gene activity is essential for organismal development, growth, and survival in a changing environment. Decisive steps regulation involve the pausing RNA polymerase II (Pol II) early elongation, controlled release paused into productive synthesis. Here we describe factors that enable events trigger Pol gene. We also discuss open questions field concerning stability II, nucleosomes as obstacles to potential roles defining precision dynamics expression.

Язык: Английский

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Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals

Molecular Cell, Год журнала: 2016, Номер 63(1), С. 167 - 178

Опубликована: Июль 1, 2016

Язык: Английский

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Understanding nucleosome dynamics and their links to gene expression and DNA replication

Nature Reviews Molecular Cell Biology, Год журнала: 2017, Номер 18(9), С. 548 - 562

Опубликована: Май 24, 2017

Язык: Английский

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