Metals to combat antimicrobial resistance

Nature Reviews Chemistry, Год журнала: 2023, Номер 7(3), С. 202 - 224

Опубликована: Фев. 8, 2023

Bacteria, similar to most organisms, have a love–hate relationship with metals: specific metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions long history of antimicrobial activity received increasing attention recent years owing the rise resistance. The search antibacterial agents now encompasses ions, nanoparticles complexes (‘metalloantibiotics’). Although advanced clinic, metalloantibiotics are vast underexplored group compounds that could lead much-needed new class antibiotics. This Review summarizes developments this growing field, focusing on advances development metalloantibiotics, particular, those which mechanism action has been investigated. We also provide an overview alternative uses combat bacterial infections, including photodynamic therapy radionuclide diagnosis infections. Metals their promising source Their 3D geometry potential multiple mechanisms important assets; however, substantial investment research is needed advance them clinic.

Язык: Английский

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Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(11), С. 2808 - 2808

Опубликована: Июнь 8, 2019

The increase in bacterial resistance to one or several antibiotics has become a global health problem. Recently, nanomaterials have tool against multidrug-resistant bacteria. metal and oxide nanoparticles are of the most studied Several vitro studies report that antimicrobial properties broad spectrum species. However, until recently, mechanisms bactericidal action had not been investigated. Some recently reported include electrostatic repulsion, ion efflux pumps, expression extracellular matrices, adaptation biofilms mutations. objective this review is summarize recent findings regarding used by bacteria counteract effects nanoparticles.

Язык: Английский

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Transcriptome landscape of a bacterial pathogen under plant immunity

Proceedings of the National Academy of Sciences, Год журнала: 2018, Номер 115(13)

Опубликована: Март 12, 2018

Plant pathogens can cause serious diseases that impact global agriculture. The plant innate immunity, when fully activated, halt pathogen growth in plants. Despite extensive studies into the molecular and genetic bases of immunity against pathogens, influence metabolism to restrict is poorly understood. Here, we developed RNA sequencing pipelines for analyzing bacterial transcriptomes planta determined high-resolution transcriptome patterns foliar Pseudomonas syringae Arabidopsis thaliana with a total 27 combinations mutants strains. Bacterial were analyzed at 6 h post infection capture early effects on processes avoid secondary caused by different population densities We identified specific "immune-responsive" genes processes, including those are activated susceptible plants suppressed immune activation. Expression immune-responsive time point tightly linked later levels host genotypes. Moreover, found iron acquisition pathway commonly multiple immune-signaling pathways. Overexpression P. sigma factor gene involved regulation other partially countered restriction during response triggered AvrRpt2. Collectively, this study defines sheds light enigmatic mechanisms inhibition response.

Язык: Английский

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Heme: emergent roles of heme in signal transduction, functional regulation and as catalytic centres

Chemical Society Reviews, Год журнала: 2019, Номер 48(24), С. 5624 - 5657

Опубликована: Янв. 1, 2019

Protoporphyrin IX iron complex (heme) is an important cofactor for oxygen transfer, storage, activation, and electron transfer when bound to the heme proteins hemoglobin, myoglobin, cytochrome P450 c, respectively. In addition these prototypical proteins, there are emergent, critical roles of exchangeable/labile in signal transduction. Specifically, it has been shown that association/dissociation to/from heme-responsive sensors regulates numerous functions, including transcription, DNA binding, microRNA splicing, translation, protein kinase activity, degradation, K+ channel function, two-component transduction, many other functions. this review, we provide a comprehensive overview structure-function relationships describe new, additional as functional inhibitors activators. order complete description various heme-bound also mention novel chemical reaction centre aldoxime dehydratase, cis-trans isomerase, N-N bond formation, hydrazine formation S-S These unprecedented functions should be interest biological chemists. Insight into underlying molecular mechanisms essential understanding new role physiological pathological processes.

Язык: Английский

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Metal-Based Nanoparticles: Antibacterial Mechanisms and Biomedical Application

Microorganisms, Год журнала: 2022, Номер 10(9), С. 1778 - 1778

Опубликована: Сен. 3, 2022

The growing increase in antibiotic-resistant bacteria has led to the search for new antibacterial agents capable of overcoming resistance problem. In recent years, nanoparticles (NPs) have been increasingly used target as an alternative antibiotics. most promising nanomaterials biomedical applications are metal and oxide NPs, due their intrinsic activity. Although NPs show interesting properties, mechanisms underlying action still poorly understood, limiting use clinical applications. this review, overview activity will be provided, relating efficacy to: (i) bacterial strain; (ii) higher microbial organizations (biofilm); (iii) physico-chemical properties NPs. addition, strategies also discussed better evaluate feasibility different treatments adopted safety fields. Finally, a wide analysis on with provided.

Язык: Английский

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Expanding ecological assessment by integrating microorganisms into routine freshwater biomonitoring

Water Research, Год журнала: 2020, Номер 191, С. 116767 - 116767

Опубликована: Дек. 23, 2020

Bioindication has become an indispensable part of water quality monitoring in most countries the world, with presence and abundance bioindicator taxa, mostly multicellular eukaryotes, used for biotic indices. In contrast, microbes (bacteria, archaea protists) are seldom as bioindicators routine assessments, although they have been recognized their importance environmental processes. Recently, use molecular methods revealed unexpected diversity within known functional groups novel metabolic pathways that particularly important energy nutrient cycling. various habitats, microbial communities respond to eutrophication, metals, natural or anthropogenic organic pollutants through changes function. this review, we evaluated common trends these changes, documenting value can be not only but also improving our understanding major processes lotic lentic environments. Current knowledge provides a solid foundation exploiting community structures diversity, well genes, programs. These measures combined into indices, resolution individual bioindicators. Here, assess particular approaches complemented by advanced bioinformatic analysis, promising respect detailed bioindication value. We conclude dynamics missing link rapid structure function aquatic ecosystems, should addressed future freshwater ecosystems.

Язык: Английский

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Conservation and diversity of radiation and oxidative stress resistance mechanisms inDeinococcusspecies

FEMS Microbiology Reviews, Год журнала: 2018, Номер 43(1), С. 19 - 52

Опубликована: Окт. 17, 2018

Deinococcus bacteria are famous for their extreme resistance to ionising radiation and other DNA damage- oxidative stress-generating agents. More than a hundred genes have been reported contribute radiation, desiccation and/or stress in radiodurans. These encode proteins involved repair, defence, regulation of yet unknown function or with an extracytoplasmic location. Here, we analysed the conservation resistance-associated radiation-resistant species. Strikingly, homologues dozens these absent one more For example, only few Deinococcus-specific regulatory present each Deinococcus, notably metallopeptidase/repressor pair IrrE/DdrO that controls radiation/desiccation response regulon. Inversely, some species possess D. radiodurans lacks, including repair consisting novel domain combinations, translesion polymerases, additional metalloregulators, redox-sensitive regulator SoxR manganese-containing catalase. Moreover, comparisons improved characterisation several regarding important conserved residues, cellular location possible protein–protein interactions. This comprehensive analysis indicates not but also large diversity molecular mechanisms even within genus.

Язык: Английский

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Zinc Essentiality, Toxicity, and Its Bacterial Bioremediation: A Comprehensive Insight

Frontiers in Microbiology, Год журнала: 2022, Номер 13

Опубликована: Май 31, 2022

Zinc (Zn) is one of the most abundantly found heavy metals in Earth’s crust and reported to be an essential trace metal required for growth living beings, with it being a cofactor major proteins, mediating regulation several immunomodulatory functions. However, its essentiality also runs parallel toxicity, which induced through various anthropogenic sources, constant exposure polluted sites, other natural phenomena. The bioavailability Zn attributable vegetables, beef, dairy products, are good source safe consumption by humans. conditions toxicity can occur overdosage supplements, increasing at alarming rate attributing lack awareness. Though humans treatable non-life-threatening condition, symptoms cause distress human activities lifestyle, including fever, breathing difficulty, nausea, chest pain, cough. In environment, generally soil water bodies, where introduced action weathering, release industrial effluents, respectively. Excessive levels these sources alter aquatic microbial diversity, thus affect absorption as well. Several Gram-positive -negative species, such Bacillus sp., Staphylococcus Streptococcus Escherichia coli , Pseudomonas Klebsiella Enterobacter respectively, have been promising agents bioremediation. This review intends present overview properties, uses, bioavailability, well mechanisms involved bioremediation from wastewaters.

Язык: Английский

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Physiological Functions of Bacterial “Multidrug” Efflux Pumps

Chemical Reviews, Год журнала: 2021, Номер 121(9), С. 5417 - 5478

Опубликована: Март 24, 2021

Bacterial multidrug efflux pumps have come to prominence in human and veterinary pathogenesis because they help bacteria protect themselves against the antimicrobials used overcome their infections. However, it is increasingly realized that many, probably most, such physiological roles are distinct from protection of administered by humans. Here we undertake a broad survey proteins involved, allied detailed examples evolution, energetics, structures, chemical recognition, molecular mechanisms, together with experimental strategies enable rapid economical progress understanding true roles. Once these established, knowledge can be harnessed design more effective drugs, improve existing microbial production drugs for clinical practice feedstocks commercial exploitation, even develop sustainable biological processes avoid, example, utilization petroleum.

Язык: Английский

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Biostimulation and toxicity: The magnitude of the impact of nanomaterials in microorganisms and plants

Journal of Advanced Research, Год журнала: 2021, Номер 31, С. 113 - 126

Опубликована: Янв. 10, 2021

Biostimulation and toxicity constitute the continuous response spectrum of a biological organism against physicochemical or factors. Among environmental agents capable inducing biostimulation are nanomaterials. On < 100 nm scale, nanomaterials impose both physical effects resulting from core’s corona’s surface properties, chemical related to composition functional groups. The purpose this review is describe impact on microorganisms plants, considering two most studied properties: size concentration. Using graphical analysis, presence biostimulation-toxicity shown different responses. In microorganisms, results showed high susceptibility Simultaneously, in hormetic was found concentration and, few cases, positive smaller when these were applied at higher level. With above, it concluded that: (1) more susceptible than (2) practically all seem induce responses (3) kind observed will depend complex way nanomateriaĺs characteristics, species with which they interact, form route application nature medium -soil, soil pore water, surfaces- where interaction occurs.

Язык: Английский

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