Science,
Год журнала:
2011,
Номер
334(6063), С. 1669 - 1675
Опубликована: Дек. 22, 2011
The
rapid
encoding
of
contextual
memory
requires
the
CA3
region
hippocampus,
but
necessary
genetic
pathways
remain
unclear.
We
found
that
activity-dependent
transcription
factor
Npas4
regulates
a
transcriptional
program
in
is
required
for
formation.
was
specifically
expressed
after
learning.
Global
knockout
or
selective
deletion
both
resulted
impaired
memory,
and
restoration
sufficient
to
reverse
deficit
global
mice.
By
recruiting
RNA
polymerase
II
promoters
enhancers
target
genes,
learning-specific
includes
many
well-known
activity-regulated
which
suggests
master
regulator
gene
programs
central
Cell Reports,
Год журнала:
2014,
Номер
7(3), С. 796 - 806
Опубликована: Апрель 17, 2014
Experience-dependent
plasticity
shapes
postnatal
development
of
neural
circuits,
but
the
mechanisms
that
refine
dendritic
arbors,
remodel
spines,
and
impair
synaptic
activity
are
poorly
understood.
Mature
brain-derived
neurotrophic
factor
(BDNF)
modulates
neuronal
morphology
plasticity,
including
long-term
potentiation
(LTP)
via
TrkB
activation.
BDNF
is
initially
translated
as
proBDNF,
which
binds
p75NTR.
In
vitro,
recombinant
proBDNF
structure
alters
hippocampal
actions
endogenously
expressed
unclear.
Therefore,
we
generated
a
cleavage-resistant
probdnf
knockin
mouse.
Our
results
demonstrate
negatively
regulates
complexity
spine
density
through
Hippocampal
slices
from
mice
exhibit
depressed
transmission,
impaired
LTP,
enhanced
depression
(LTD)
in
area
CA1.
These
suggest
acts
vivo
biologically
active
structure,
effects
distinct
those
mature
BDNF.
Science,
Год журнала:
2011,
Номер
334(6063), С. 1669 - 1675
Опубликована: Дек. 22, 2011
The
rapid
encoding
of
contextual
memory
requires
the
CA3
region
hippocampus,
but
necessary
genetic
pathways
remain
unclear.
We
found
that
activity-dependent
transcription
factor
Npas4
regulates
a
transcriptional
program
in
is
required
for
formation.
was
specifically
expressed
after
learning.
Global
knockout
or
selective
deletion
both
resulted
impaired
memory,
and
restoration
sufficient
to
reverse
deficit
global
mice.
By
recruiting
RNA
polymerase
II
promoters
enhancers
target
genes,
learning-specific
includes
many
well-known
activity-regulated
which
suggests
master
regulator
gene
programs
central
