The machineries, regulation and cellular functions of mitochondrial calcium

Nature Reviews Molecular Cell Biology, Год журнала: 2018, Номер 19(11), С. 713 - 730

Опубликована: Авг. 24, 2018

Язык: Английский

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A comprehensive review of amyotrophic lateral sclerosis

Surgical Neurology International, Год журнала: 2015, Номер 6(1), С. 171 - 171

Опубликована: Янв. 1, 2015

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting motor neurons with an incidence of about 1/100,000.Most ALS cases are sporadic, but 5-10% the familial ALS.Both sporadic and (FALS) associated degeneration cortical spinal neurons.The etiology remains unknown.However, mutations superoxide dismutase 1 have been known as most common cause FALS.In this study, we provide comprehensive review ALS.We cover all aspects including epidemiology, comorbidities, environmental risk factor, molecular mechanism, genetic factors, symptoms, diagnostic, treatment, even available supplement management ALS.This will reader advantage receiving broad range information disease.

Язык: Английский

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Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture

Neuron, Год журнала: 2017, Номер 96(3), С. 651 - 666

Опубликована: Ноя. 1, 2017

Язык: Английский

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Mitochondrial dynamics in neurodegeneration

Trends in Cell Biology, Год журнала: 2012, Номер 23(2), С. 64 - 71

Опубликована: Ноя. 16, 2012

Язык: Английский

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Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

Cell, Год журнала: 2019, Номер 176(1-2), С. 56 - 72.e15

Опубликована: Янв. 1, 2019

Local translation regulates the axonal proteome, playing an important role in neuronal wiring and axon maintenance. How mRNAs are localized to specific subcellular sites for translation, however, is not understood. Here we report that RNA granules associate with endosomes along axons of retinal ganglion cells. RNA-bearing Rab7a late also ribosomes, real-time imaging reveals they local protein synthesis. We show often pause on mitochondria encoding proteins mitochondrial function translated endosomes. Disruption mutants, including those associated Charcot-Marie-Tooth type 2B neuropathy, markedly decreases synthesis, impairs function, compromises viability. Our findings thus reveal interact granules, machinery, suggest serve as regulating supply nascent pro-survival axons.

Язык: Английский

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A cannabinoid link between mitochondria and memory

Nature, Год журнала: 2016, Номер 539(7630), С. 555 - 559

Опубликована: Ноя. 1, 2016

Язык: Английский

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Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

Cells, Год журнала: 2019, Номер 8(5), С. 488 - 488

Опубликована: Май 22, 2019

Alzheimer's disease (AD) is a progressive neurodegenerative characterized by memory loss and multiple cognitive impairments. Several decades of intense research have revealed that cellular changes are implicated in the development progression AD, including mitochondrial damage, synaptic dysfunction, amyloid beta (Aβ) formation accumulation, hyperphosphorylated tau (P-Tau) deregulated microRNAs, neuronal patients with AD. Among these, dysfunction damage early events process. Recent also Aβ P-Tau-induced defective autophagy mitophagy prominent AD pathogenesis. Age-dependent increased levels P-Tau reduced several proteins. In addition, abnormal interactions between (1) fission protein Drp1; (2) (3) PINK1/parkin lead to an inability clear damaged mitochondria other debris from neurons. These occur selectively affected The purpose our article highlight recent developments This summarizes aspects dynamics (increased fusion), biogenesis, ATP, free radicals lipid peroxidation, decreased cytochrome c oxidase (COX) activity calcium dyshomeostasis Our discusses how Drp1, Aβ, can enhance clearance mechanisms.

Язык: Английский

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Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony

Trends in Neurosciences, Год журнала: 2017, Номер 40(6), С. 347 - 357

Опубликована: Май 8, 2017

Язык: Английский

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Mitochondrial trafficking and anchoring in neurons: New insight and implications

The Journal of Cell Biology, Год журнала: 2014, Номер 204(7), С. 1087 - 1098

Опубликована: Март 31, 2014

Mitochondria are essential organelles for neuronal growth, survival, and function. Neurons use specialized mechanisms to drive mitochondria transport anchor them in axons at synapses. Stationary buffer intracellular Ca(2+) serve as a local energy source by supplying ATP. The balance between motile stationary responds quickly changes axonal synaptic physiology. Defects mitochondrial implicated the pathogenesis of several major neurological disorders. Recent work has provided new insight regulation microtubule-based trafficking anchoring, on how motility influences neuron function, mitophagy.

Язык: Английский

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Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling

Mitochondrion, Год журнала: 2019, Номер 49, С. 35 - 45

Опубликована: Июль 6, 2019

Язык: Английский

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