Molecular Biology and Evolution,
Год журнала:
2015,
Номер
32(8), С. 1928 - 1947
Опубликована: Апрель 3, 2015
The
cnidarian
freshwater
polyp
Hydra
sp.
exhibits
an
unparalleled
regeneration
capacity
in
the
animal
kingdom.
Using
integrative
transcriptomic
and
stable
isotope
labeling
by
amino
acids
cell
culture
proteomic/phosphoproteomic
approach,
we
studied
stem
cell-based
polyps.
As
major
contributors
to
head
regeneration,
identified
diverse
signaling
pathways
adopted
for
response
as
well
enriched
novel
genes.
Our
global
analysis
reveals
two
distinct
molecular
cascades:
early
injury
a
subsequent,
driven
patterning
of
regenerating
tissue.
A
key
factor
initial
is
general
stabilization
proteins
net
upregulation
transcripts,
which
followed
subsequent
activation
cascade
molecules
including
Wnts
transforming
growth
(TGF)
beta-related
factors.
We
observed
moderate
overlap
between
factors
contributing
proteomic
responses
suggesting
decoupled
regulation
transcriptional
translational
levels.
data
also
indicate
that
interstitial
cells
their
derivatives
(e.g.,
neurons)
have
no
role
regeneration.
Remarkably,
found
enrichment
evolutionarily
more
recent
genes
response,
whereas
conserved
are
late
phase.
In
addition,
specific
were
transposon
insertions.
Genetic
dynamicity
taxon-specific
might
therefore
play
hitherto
underestimated
Science,
Год журнала:
2018,
Номер
359(6382), С. 1416 - 1421
Опубликована: Март 22, 2018
How
is
protein
synthesis
initiated
locally
in
neurons?
We
found
that
mTOR
(mechanistic
target
of
rapamycin)
was
activated
and
then
up-regulated
injured
axons,
owing
to
local
translation
messenger
RNA
(mRNA).
This
mRNA
transported
into
axons
by
the
cell
size-regulating
RNA-binding
nucleolin.
Furthermore,
controlled
axons.
included
regulation
its
own
retrograde
injury
signaling
molecules
such
as
importin
β1
STAT3
(signal
transducer
activator
transcription
3).
Deletion
3'
untranslated
region
(3'UTR)
mice
reduced
decreased
after
nerve
injury.
Both
pharmacological
inhibition
deletion
3'UTR
proprioceptive
neuronal
survival
Thus,
localization
enables
spatiotemporal
control
pathways
regulating
long-range
intracellular
signaling.
International Journal of Biological Sciences,
Год журнала:
2019,
Номер
16(1), С. 116 - 134
Опубликована: Дек. 6, 2019
Peripheral
nerve
injury
is
a
complex
condition
with
variety
of
signs
and
symptoms
such
as
numbness,
tingling,
jabbing,
throbbing,
burning
or
sharp
pain.Peripheral
nerves
are
fragile
in
nature
can
easily
get
damaged
due
to
acute
compression
trauma
which
may
lead
the
sensory
motor
functions
deficits
even
lifelong
disability.After
lesion,
neuronal
cell
body
becomes
disconnected
from
axon's
distal
portion
site
leading
axonal
degeneration
dismantlement
neuromuscular
junctions
targeted
muscles.In
spite
extensive
research
on
this
aspect,
complete
functional
recovery
still
remains
challenge
be
resolved.This
review
highlights
detailed
pathophysiological
events
after
an
peripheral
associated
factors
that
either
hinder
promote
regenerative
machinery.In
addition,
it
throws
light
available
therapeutic
strategies
including
supporting
therapies,
surgical
non-surgical
interventions
ameliorate
regeneration,
survival,
reinnervation
targets.Despite
availability
various
treatment
options,
we
lacking
optimal
treatments
for
perfect
regain.The
need
present
age
discover
design
potent
compounds
would
able
execute
retrieval.In
regard,
plant-derived
getting
more
attention
several
recent
reports
validate
their
remedial
effects.A
plethora
plants
phytochemicals
have
been
suggested
curative
effects
against
number
diseases
general
particular.They
ray
hope
suffering
individuals.
