Neurotoxicology and Teratology, Год журнала: 2016, Номер 58, С. 5 - 14
Опубликована: Авг. 29, 2016
Язык: Английский
Neurotoxicology and Teratology, Год журнала: 2016, Номер 58, С. 5 - 14
Опубликована: Авг. 29, 2016
Язык: Английский
Physiological Reviews, Год журнала: 2017, Номер 97(4), С. 1619 - 1747
Опубликована: Сен. 28, 2017
In the hippocampus GABAergic local circuit inhibitory interneurons represent only ~10–15% of total neuronal population; however, their remarkable anatomical and physiological diversity allows them to regulate virtually all aspects cellular function. Here we provide an overview current state field interneuron research, focusing largely on hippocampus. We discuss recent advances related various cell types, including development maturation, expression subtype-specific voltage- ligand-gated channels, roles in network oscillations. also technological approaches that have permitted high-resolution, examination numerous neural disorders emerging therapeutic strategies ameliorate such pathophysiological conditions. The ultimate goal this review is not a touchstone for field, but help pave way future research by highlighting where gaps our knowledge exist how complete appreciation will aid strategies.
Язык: Английский
Процитировано
780Trends in Pharmacological Sciences, Год журнала: 2015, Номер 36(5), С. 277 - 296
Опубликована: Март 28, 2015
Язык: Английский
Процитировано
603Nature reviews. Neuroscience, Год журнала: 2015, Номер 16(12), С. 705 - 718
Опубликована: Ноя. 20, 2015
Язык: Английский
Процитировано
433Nature reviews. Neuroscience, Год журнала: 2015, Номер 16(10), С. 579 - 594
Опубликована: Сен. 16, 2015
Язык: Английский
Процитировано
428Nature Reviews Drug Discovery, Год журнала: 2018, Номер 17(9), С. 623 - 639
Опубликована: Авг. 17, 2018
Язык: Английский
Процитировано
421Physiological Reviews, Год журнала: 2016, Номер 96(4), С. 1593 - 1659
Опубликована: Сен. 15, 2016
Apart from having been used and misused for at least four millennia for, among others, recreational medicinal purposes, the cannabis plant its most peculiar chemical components, cannabinoids (phytocannabinoids), have merit to led humanity discover one of intriguing pleiotropic endogenous signaling systems, endocannabinoid system (ECS). This review article aims describe critically discuss, in comprehensive possible manner, multifaceted aspects 1) pharmacology potential impact on mammalian physiology all major phytocannabinoids, not only famous Δ 9 -tetrahydrocannabinol, 2) adaptive pro-homeostatic physiological, or maladaptive pathological, roles ECS cells, tissues, organs. In doing so, we respected chronological order milestones millennial route medicinal/recreational beyond, as it is now clear that some early steps this long path, which were originally neglected, are becoming important again. The emerging picture rather complex, but still supports belief more discoveries human physiology, new therapies, might come future knowledge field.
Язык: Английский
Процитировано
418Frontiers in Immunology, Год журнала: 2018, Номер 9
Опубликована: Янв. 29, 2018
Inflammation is an immune response that works as a contained fire pre-emptively sparked defensive process during infections or upon any kind of tissue insult, and spontaneously extinguished after elimination termination the damage. However, persistent uncontrolled reactions act wildfire promote chronic inflammation, unresolved damage and, eventually, diseases. A wide network soluble mediators, among which endogenous bioactive lipids, governs all processes. They are secreted by basically cells involved in inflammatory processes constitute crucial infrastructure trigger, coordinate confine mechanisms. these molecules also deeply detrimental transition from to be it for excessive action pro-inflammatory lipids impairment functions carried out resolving ones. As matter fact, have been linked, date, several diseases, including rheumatoid arthritis, atherosclerosis, diabetes, cancer, bowel disease, lupus multiple sclerosis. This review summarizes current knowledge on involvement main classes – namely classical eicosanoids, pro-resolving lipid lysoglycerophospholipids/sphingolipids endocannabinoids cellular molecular mechanisms lead pathogenesis disorders.
Язык: Английский
Процитировано
379Nature Communications, Год журнала: 2017, Номер 8(1)
Опубликована: Янв. 3, 2017
Abstract The cannabinoid CB 2 receptor (CB R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed widely used to R, their selectivity, molecular mode action pharmacokinetic properties poorly characterized. Here we report the most extensive characterization pharmacology R ligands date. In collaborative effort between multiple academic industry laboratories, identify marked differences in ability certain agonists activate distinct signalling pathways cause off-target effects. We reach consensus that HU910, HU308 JWH133 are recommended selective study role biological disease processes. believe our unique approach would be highly suitable other targets drug discovery research.
Язык: Английский
Процитировано
312Frontiers in Cellular Neuroscience, Год журнала: 2017, Номер 10
Опубликована: Янв. 3, 2017
The identification and cloning of the two major cannabinoid (CB¬1 CB2) receptors together with discovery their endogenous ligands in late 80s early 90s, resulted a effort aimed at understanding mechanisms physiological roles endocannabinoid system (ECS). Due to its expression localization central nervous (CNS), CB1 receptor (endocannabinoids) enzymes involved synthesis degradation, has been implicated multiple pathophysiological events ranging from memory deficits neurodegenerative disorders among others. In this review, we will provide general overview emphasis on health disease. We describe our current complex aspects signaling trafficking, including non-canonical pathways such as those mediated by β-arrestins within context functional selectivity ligand bias. Finally, highlight some which have implicated. Significant knowledge achieved over last 30 years. However, much more research is still needed fully understand system, particularly vivo, unlock true potential source therapeutic targets.
Язык: Английский
Процитировано
306Advances in pharmacology, Год журнала: 2017, Номер unknown, С. 169 - 206
Опубликована: Янв. 1, 2017
Язык: Английский
Процитировано
303