CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease

Nature Reviews Nephrology, Год журнала: 2018, Номер 14(6), С. 361 - 377

Опубликована: Апрель 13, 2018

Язык: Английский

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Update of pathophysiology and management of diabetic kidney disease

Journal of the Formosan Medical Association, Год журнала: 2018, Номер 117(8), С. 662 - 675

Опубликована: Март 2, 2018

Diabetic kidney disease (DKD) is a major cause of morbidity and mortality in patients with diabetes mellitus the leading end-stage renal world. The most characteristic marker DKD albuminuria, which associated progression cardiovascular events. Renal hemodynamics changes, oxidative stress, inflammation, hypoxia overactive renin-angiotensin-aldosterone system (RAAS) are involved pathogenesis DKD, fibrosis plays key role. Intensified multifactorial interventions, including RAAS blockades, blood pressure glucose control, quitting smoking, help to prevent development progression. In recent years, novel agents applied for preventing progression, new types glucose-lowering agents, pentoxifylline, vitamin D analog paricalcitol, pyridoxamine, ruboxistaurin, soludexide, Janus kinase inhibitors nonsteroidal minerocorticoid receptor antagonists. this review, large studies about also summarized.

Язык: Английский

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Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

Cell Metabolism, Год журнала: 2019, Номер 30(4), С. 784 - 799.e5

Опубликована: Авг. 29, 2019

Язык: Английский

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Interleukin-18 in Health and Disease

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(3), С. 649 - 649

Опубликована: Фев. 2, 2019

Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing which increase response to stimulation. Therefore, IL-12 is commitment induces development cells. In contrast, proinflammatory cytokine facilitates type 1 responses. However, without but IL-2, stimulates NK CD4+ NKT and established produce IL-3, IL-9, IL-13. Furthermore, together mast basophils IL-4, IL-13, chemical mediators such histamine. various cell types has pleiotropic functions. member IL-1 family cytokines. demonstrates unique function by binding specific expressed on this review article, we will focus features health disease experimental animals humans.

Язык: Английский

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The role of the complement system in diabetic nephropathy

Nature Reviews Nephrology, Год журнала: 2017, Номер 13(5), С. 311 - 318

Опубликована: Март 6, 2017

Язык: Английский

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IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline

Proceedings of the National Academy of Sciences, Год журнала: 2016, Номер 113(19)

Опубликована: Апрель 18, 2016

Significance Dysfunction of the innate immune system is involved in pathogenesis Alzheimer’s disease (AD); however, pathophysiological mechanisms underlying these dysfunctions are unclear. Here we report that stimulation IL-33/ST2 signaling rescues memory deficits and reduces accumulation β-amyloid APP/PS1 mice exhibit select pathologies associated with AD. Although impaired early progression AD, IL-33 injection contextual mice. skews microglia toward an alternative activation state enhanced Aβ phagocytic capacity elevated antiinflammatory gene expression, which results a decreased proinflammatory response brain. Thus, this study suggests can be developed as new therapeutic intervention for

Язык: Английский

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Diabetic nephropathy – is this an immune disorder?

Clinical Science, Год журнала: 2017, Номер 131(16), С. 2183 - 2199

Опубликована: Июль 31, 2017

Chronic diabetes is associated with metabolic and haemodynamic stresses which can facilitate modifications to DNA, proteins lipids, induce cellular dysfunction damage, stimulate inflammatory fibrotic responses lead various types of renal injury. Approximately 30–40% patients develop nephropathy this injury normally progresses in about a third patients. Due the growing incidence diabetes, diabetic now main cause end-stage disease (ESRD) worldwide. Accumulating evidence from experimental clinical studies has demonstrated that inflammation plays critical role determining whether during diabetes. However, immune response considerably different seen autoimmune kidney diseases or acute arising episodes ischaemia infection. This review evaluates system development nephropathy, including specific contributions leucocyte subsets (macrophages, neutrophils, mast cells, T B lymphocytes), danger-associated molecular patterns (DAMPs), inflammasomes, immunoglobulin complement. It also examines factors may influence response, genetic exposure other insults. In addition, discusses therapies are currently under for targeting indicates those have proceeded into trials.

Язык: Английский

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Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases

Basic Research in Cardiology, Год журнала: 2017, Номер 113(1)

Опубликована: Дек. 9, 2017

Язык: Английский

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Signaling pathways of chronic kidney diseases, implications for therapeutics

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Июнь 9, 2022

Abstract Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that characterized by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) deposition. Lipotoxicity oxidative stress are the driving force for loss of including tubules, glomerulus, endothelium. NLRP3 inflammasome signaling, MAPK PI3K/Akt RAAS signaling involves in lipotoxicity. The upregulated Nox expression decreased Nrf2 result directly. injured resident cells release proinflammatory cytokines chemokines to recruit immune such as macrophages from bone marrow. NF-κB JAK-STAT Toll-like receptor cGAS-STING major pathways mediate inflammation inflammatory cells. produce secret great number profibrotic TGF-β1, Wnt ligands, angiotensin II. TGF-β Notch evoke activation promote generation ECM. potential therapies targeted these also introduced here. In this review, we update key lipotoxicity, stress, kidneys with injury, drugs based on latest studies. Unifying will be instrumental advance further basic clinical investigation CKD.

Язык: Английский

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Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(11), С. 3798 - 3798

Опубликована: Май 27, 2020

Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting in elevated cost for public health systems. DN the main cause of chronic kidney disease (CKD) its incidence increases number patients that develop end-stage renal (ESRD). There are growing epidemiological preclinical evidence about close relationship between inflammatory response occurrence progression DN. Several anti-inflammatory strategies targeting specific mediators (cell adhesion molecules, chemokines cytokines) intracellular signaling pathways have shown beneficial effects experimental models DN, decreasing proteinuria lesions. A molecules been useful to identify diabetic at high risk developing complications. In this review, we focus on key role inflammation genesis a special interest effector activated leading damage, as well comprehensive update new therapeutic prevent and/or retard injury.

Язык: Английский

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