Abstract
Using
targeted
NMR
spectroscopy
of
227
fasting
serum
metabolic
traits,
we
searched
for
novel
signatures
renal
function
in
926
type
2
diabetics
(T2D)
and
4838
non-diabetic
individuals
from
four
independent
cohorts.
We
furthermore
investigated
longitudinal
changes
measures
associations
with
other
T2D
microvascular
complications.
142
traits
correlated
glomerular
filtration
rate
(eGFR)
after
adjusting
confounders
multiple
testing:
59
diabetics,
109
non-diabetics
26
overlapping.
The
amino
acids
glycine
phenylalanine
the
energy
metabolites
citrate
glycerol
were
negatively
associated
eGFR
all
cohorts,
while
alanine,
valine
pyruvate
depicted
opposite
association
(positive)
(negative).
Moreover,
triglyceride
content
different
lipoprotein
subclasses
showed
a
negative
eGFR,
cholesterol,
cholesterol
esters
(CE),
phospholipids
HDL
better
function.
In
contrast,
CEs
LDL
positive
only
T2D,
phospholipid
was
positively
both
cross-sectionally
longitudinally
non-diabetics.
conclusion,
provide
wide
list
kidney
function–associated
identified
differences
between
diabetic
disease.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Июнь 9, 2022
Abstract
Chronic
kidney
disease
(CKD)
is
a
chronic
renal
dysfunction
syndrome
that
characterized
by
nephron
loss,
inflammation,
myofibroblasts
activation,
and
extracellular
matrix
(ECM)
deposition.
Lipotoxicity
oxidative
stress
are
the
driving
force
for
loss
of
including
tubules,
glomerulus,
endothelium.
NLRP3
inflammasome
signaling,
MAPK
PI3K/Akt
RAAS
signaling
involves
in
lipotoxicity.
The
upregulated
Nox
expression
decreased
Nrf2
result
directly.
injured
resident
cells
release
proinflammatory
cytokines
chemokines
to
recruit
immune
such
as
macrophages
from
bone
marrow.
NF-κB
JAK-STAT
Toll-like
receptor
cGAS-STING
major
pathways
mediate
inflammation
inflammatory
cells.
produce
secret
great
number
profibrotic
TGF-β1,
Wnt
ligands,
angiotensin
II.
TGF-β
Notch
evoke
activation
promote
generation
ECM.
potential
therapies
targeted
these
also
introduced
here.
In
this
review,
we
update
key
lipotoxicity,
stress,
kidneys
with
injury,
drugs
based
on
latest
studies.
Unifying
will
be
instrumental
advance
further
basic
clinical
investigation
CKD.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Фев. 21, 2024
Abstract
Lipids
play
crucial
roles
in
many
biological
processes.
Mapping
spatial
distributions
and
examining
the
metabolic
dynamics
of
different
lipid
subtypes
cells
tissues
are
critical
to
better
understanding
their
aging
diseases.
Commonly
used
imaging
methods
(such
as
mass
spectrometry-based,
fluorescence
labeling,
conventional
optical
imaging)
can
disrupt
native
environment
cells/tissues,
have
limited
or
spectral
resolution,
cannot
distinguish
subtypes.
Here
we
present
a
hyperspectral
platform
that
integrates
Penalized
Reference
Matching
algorithm
with
Stimulated
Raman
Scattering
(PRM-SRS)
microscopy.
Using
this
platform,
visualize
identify
high
density
lipoprotein
particles
human
kidney,
cholesterol
phosphatidylethanolamine
ratio
inside
granule
mouse
hippocampus,
subcellular
sphingosine
cardiolipin
brain.
Our
PRM-SRS
displays
unique
advantages
enhanced
chemical
specificity,
fast
data
processing
distinguishing
organs
species.
Paediatrics and International Child Health,
Год журнала:
2017,
Номер
37(4), С. 248 - 258
Опубликована: Сен. 15, 2017
Nephrotic
syndrome
is
defined
by
nephrotic-range
proteinuria
(≥40
mg/m2/hour
or
urine
protein/creatinine
ratio
≥200
mg/mL
3+
protein
on
dipstick),
hypoalbuminaemia
(<25
g/L)
and
oedema.
This
review
focuses
the
classification,
epidemiology,
pathophysiology,
management
strategies
prognosis
of
idiopathic
nephrotic
childhood,
includes
a
brief
overview
congenital
forms.
Blood Purification,
Год журнала:
2018,
Номер
46(2), С. 144 - 152
Опубликована: Янв. 1, 2018
Cardiovascular
disease
(CVD)
is
the
leading
cause
of
death
in
chronic
kidney
(CKD).
One
most
important
pathophysiological
mechanisms
for
CVD
patients
with
CKD
widespread
and
possibly
accelerated
formation
atherosclerotic
plaques
due
to
hyperlipidemia,
uremic
toxins,
inflammation,
oxidative
stress,
endothelial
dysfunction.
Recent
studies
showed
that
level
oxidized
low-density
lipoprotein
cholesterol
increases,
high--density
dysfunction
occurs
as
function
declines
inflammation
becomes
more
prevalent.
In
this
review,
we
aimed
discuss
effect
dysfunction,
on
lipid
-profile.
Circulation,
Год журнала:
2016,
Номер
134(1), С. 61 - 72
Опубликована: Июнь 29, 2016
Background:
In
nephrotic
syndrome,
damage
to
the
podocytes
of
kidney
produces
severe
hypercholesterolemia
for
which
novel
treatments
are
urgently
needed.
PCSK9
(proprotein
convertase
subtilisin/kexin
type
9)
has
emerged
as
an
important
regulator
plasma
cholesterol
levels
and
therapeutic
target.
Here,
we
tested
role
in
mediating
syndrome.
Methods:
lipids
were
studied
syndrome
patients
before
after
remission
disease,
mice
with
genetic
ablation
podocyte
(Podocyte
Apoptosis
Through
Targeted
Activation
Caspase-8,
Pod-ATTAC
mice)
treated
nephrotoxic
serum
(NTS),
triggers
immune-mediated
damage.
addition,
hepatic
deletion
Pcsk9
NTS
determine
contribution
dyslipidemia
Results:
Patients
showed
a
decrease
on
their
disease
(
P
<0.05,
n=47–50).
Conversely,
NTS-treated
7-
24-fold
induction
PCSK9.
The
appeared
be
attributable
increased
secretion
from
hepatocyte
coupled
decreased
clearance.
Interestingly,
knockout
ameliorated
effects
lipids.
Thus,
presence
NTS,
lacking
40%
50%
triglycerides.
Moreover,
ability
treatment
increase
percentage
low-density
lipoprotein–associated
(from
9%
vehicle-treated
Flox
47%
treatment),
was
lost
(5%
both
absence
NTS).
Conclusions:
Podocyte
marked
inductions
PCSK9,
ameliorates
mouse
model
These
data
suggest
that
inhibitors
may
beneficial
syndrome–associated
hypercholesterolemia.
