Alleviation of Oral Exposure to Aflatoxin B1-Induced Renal Dysfunction, Oxidative Stress, and Cell Apoptosis in Mice Kidney by Curcumin

Antioxidants, Год журнала: 2022, Номер 11(6), С. 1082 - 1082

Опубликована: Май 29, 2022

Aflatoxin B1 is a contaminant widely found in food and livestock feed, posing major threat to human animal health. Recently, much attention from the pharmaceutical industries has been focused on curcumin due its strong antioxidant capacity. However, therapeutic impacts potential mechanisms of kidney damage caused by AFB1 are still incomplete. In this study, triggered renal injury mice, as reflected pathological changes dysfunction. induced oxidative stress interfered with Keap1-Nrf2 pathway downstream genes (CAT, SOD1, NQO1, GSS, GCLC, GCLM), manifested elevated metabolites reduced enzymes activities. Additionally, was increase apoptotic cells percentage via TUNEL assay, along increased expression Cyt-c, Bax, cleaved-Caspase-3, Caspase-9, decreased Bcl-2 at transcriptional protein levels; contrast, for mice given curcumin, there significant reversal coefficient, biochemical parameters, changes, proteins involved apoptosis. These results indicate that could antagonize apoptosis attenuate AFB1-induced damage.

Язык: Английский

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The Role of Exercise, Diet, and Cytokines in Preventing Obesity and Improving Adipose Tissue

Nutrients, Год журнала: 2021, Номер 13(5), С. 1459 - 1459

Опубликована: Апрель 25, 2021

The prevalence of obesity continues to rise worldwide despite evidence-based public health recommendations. promise adopt a healthy lifestyle is increasingly important for tackling this global epidemic. Calorie restriction or regular exercise combination the two accepted as an effective strategy in preventing treating obesity. Furthermore, benefits conferred by overcome are attributed not only reduced adiposity levels circulating lipids but also proteins, peptides, enzymes, and metabolites that released from contracting skeletal muscle other organs. secretion these molecules called cytokines response induces browning white adipose tissue increasing expression brown adipocyte-specific genes within tissue, suggesting exercise-induced may play significant role In review, we present research-based evidence supporting effects various diet interventions on health. We discuss interplay between secreted organs known affect metabolism.

Язык: Английский

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Nuciferine, an active ingredient derived from lotus leaf, lights up the way for the potential treatment of obesity and obesity-related diseases

Pharmacological Research, Год журнала: 2021, Номер 175, С. 106002 - 106002

Опубликована: Ноя. 24, 2021

Язык: Английский

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Impact of Obesity in Kidney Diseases

Nutrients, Год журнала: 2021, Номер 13(12), С. 4482 - 4482

Опубликована: Дек. 15, 2021

The clinical consequences of obesity on the kidneys, with or without metabolic abnormalities, involve both renal function and structures. mechanisms linking damage are well understood, including several effector interconnected pathways. Higher prevalence urinary albumin excretion, sub-nephrotic syndrome, nephrolithiasis, increased risk developing CKD, progression to ESKD have been identified as being associated having a relevant impact. Moreover, replacement therapy kidney transplantation also influenced by obesity. Losing weight is key in limiting impact that produces kidneys reducing albuminuria/proteinuria, declining rate eGFR deterioration, delaying development CKD ESKD, improving outcome transplant. Weight reduction may contribute appropriate control cardiometabolic factors such hypertension, diabetes, dyslipidemia which be protective not only but cardiovascular disease. Lifestyle changes, some drugs, bariatric surgery demonstrated benefits.

Язык: Английский

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Kidney Damage Caused by Obesity and Its Feasible Treatment Drugs

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(2), С. 747 - 747

Опубликована: Янв. 11, 2022

The rapid growth of obesity worldwide has made it a major health problem, while the dramatic increase in prevalence had significant impact on magnitude chronic kidney disease (CKD), especially developing countries. A vast amount researchers have reported strong relationship between and disease, can serve as an independent risk factor for disease. histological changes kidneys obesity-induced renal injury include glomerular or tubular hypertrophy, focal segmental glomerulosclerosis bulbous sclerosis. Furthermore, inflammation, hemodynamic changes, insulin resistance lipid metabolism disorders are all involved development progression nephropathy. However, there is no targeted treatment obesity-related In this review, RAS inhibitors, SGLT2 inhibitors melatonin would be presented to treat injury. we concluded that protect damage caused by inhibiting inflammation oxidative stress, revealing its therapeutic potential.

Язык: Английский

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The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia

Journal of the American Society of Nephrology, Год журнала: 2022, Номер 33(7), С. 1377 - 1389

Опубликована: Май 2, 2022

Insulin resistance, hypertension, hyperuricemia, and hypercholesterolemia are hypothesized to be important intermediates in the relationship between excess body weight CKD risk. However, magnitude of total effect on ESKD mediated through these four pathways remains quantified.

Язык: Английский

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The role of lipotoxicity in kidney disease: From molecular mechanisms to therapeutic prospects

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 161, С. 114465 - 114465

Опубликована: Март 3, 2023

Lipotoxicity is the dysregulation of lipid environment and/or intracellular composition that leads to accumulation harmful lipids and ultimately organelle dysfunction, abnormal activation signaling pathways, chronic inflammation cell death. It plays an important role in development acute kidney injury disease, including diabetic nephropathy, obesity-related glomerulopathy, age-related polycystic like. However, mechanisms overload remain poorly understood. Herein, we discuss two pivotal aspects lipotoxic injury. First, analyzed mechanism kidney. Accumulating data indicate different diseases are inconsistent. Second, summarize multiple by which species affect behavior, oxidative stress, endoplasmic reticulum mitochondrial dysregulated autophagy, inflammation, highlighting central stress. Blocking molecular pathways damage may be potential therapeutic targets for antioxidant drugs play a treatment disease future.

Язык: Английский

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Independent and joint associations of monocyte to high-density lipoprotein-cholesterol ratio and body mass index with cardiorenal syndrome: insights from NHANES 2003–2020

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Май 23, 2024

Abstract Background With the development of pathophysiology, cardiorenal syndrome (CRS), a complex and severe disease, has received increasing attention. Monocyte to high-density lipoprotein-cholesterol ratio (MHR) body mass index (BMI) are independent risk factors for cardiovascular diseases, but their association with CRS remains unexplored. This study aims explore joint effects MHR BMI on CRS. Methods We included 42,178 NHANES participants. The determination referred simultaneous presence disease (identified through self-report) chronic kidney (eGFR < 60 mL/min per 1.73 m²). employed multivariate weighted logistic regression evaluate odds (OR) 95% confidence interval (CI) associations also conducted restricted cubic spines nonlinear associations. Results prevalence was 3.45% among all An increase in both is associated higher (MHR: OR = 1.799, CI 1.520–2.129, P 0.001, -trend 0.001; BMI: 1.037, 1.023–1.051, 0.001). Individuals who simultaneously fall into highest quartile have 30 or more face compared those lowest less than 25 (OR 3.45, 2.40–4.98, However, there no interactive between Conclusions Higher can serve as tools early prevention intervention CRS, respectively.

Язык: Английский

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The role of thiamine dependent enzymes in obesity and obesity related chronic disease states: A systematic review

Clinical Nutrition ESPEN, Год журнала: 2018, Номер 25, С. 8 - 17

Опубликована: Март 15, 2018

Язык: Английский

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The emerging role of dyslipidemia in diabetic microvascular complications

Current Opinion in Endocrinology Diabetes and Obesity, Год журнала: 2020, Номер 27(2), С. 115 - 123

Опубликована: Фев. 19, 2020

To summarize recent advancements in our understanding of the impact dyslipidemia on microvascular complications type 2 diabetes (T2D), with an emphasis peripheral neuropathy and nephropathy.

Язык: Английский

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