AJP Renal Physiology,
Год журнала:
2020,
Номер
319(6), С. F1105 - F1116
Опубликована: Окт. 19, 2020
Acute
kidney
injury
(AKI)
has
been
widely
recognized
as
an
important
risk
factor
for
the
occurrence
and
development
of
chronic
disease
(CKD).
Even
milder
AKI
adverse
consequences
could
progress
to
renal
fibrosis,
which
is
ultimate
common
pathway
various
terminal
diseases.
Thus,
it
urgent
develop
a
strategy
hinder
transition
from
CKD.
Some
mechanisms
AKI-to-CKD
have
revealed,
such
nephron
loss,
cell
cycle
arrest,
persistent
inflammation,
endothelial
with
vascular
rarefaction,
epigenetic
changes.
Previous
studies
elucidated
pivotal
role
mitochondria
in
acute
injuries
demonstrated
that
fitness
this
organelle
major
determinant
both
pathogenesis
recovery
organ
function.
Recent
research
suggested
damage
mitochondrial
function
early
crucial
leading
tubular
insufficiency.
Dysregulation
homeostasis,
alterations
bioenergetics,
stress
cross
talk
contribute
transition.
In
review,
we
focus
on
pathophysiology
after
progression
CKD,
confirming
targeting
represents
potentially
effective
therapeutic
Theranostics,
Год журнала:
2019,
Номер
9(6), С. 1698 - 1713
Опубликована: Янв. 1, 2019
Elevated
levels
of
plasma
free
fatty
acid
(FFA)
and
disturbed
mitochondrial
dynamics
play
crucial
roles
in
the
pathogenesis
diabetic
kidney
disease
(DKD).However,
mechanisms
by
which
FFA
leads
to
damage
glomerular
podocytes
DKD
effects
Berberine
(BBR)
on
are
not
fully
understood.Methods:
Using
db/db
mice
model
cultured
mouse
podocytes,
we
investigated
molecular
mechanism
FFA-induced
disturbance
testified
BBR
regulating
dysfunction,
podocyte
apoptosis
glomerulopathy
progression
DKD.Results:
Intragastric
administration
for
8
weeks
significantly
reversed
glucose
lipid
metabolism
disorders,
damage,
basement
membrane
thickening,
mesangial
expansion
glomerulosclerosis.BBR
strongly
inhibited
apoptosis,
increased
reactive
oxygen
species
(ROS)
generation,
fragmentation
dysfunction
both
vivo
vitro.Mechanistically,
could
stabilize
morphology
via
abolishing
palmitic
(PA)-induced
activation
dynamin-related
protein
1
(Drp1).Conclusions:
Our
study
demonstrated
first
time
that
may
have
a
previously
unrecognized
role
protecting
glomerulus
positively
Drp1-mediated
dynamics.It
might
serve
as
novel
therapeutic
drug
treatment
DKD.
AJP Renal Physiology,
Год журнала:
2020,
Номер
319(6), С. F1105 - F1116
Опубликована: Окт. 19, 2020
Acute
kidney
injury
(AKI)
has
been
widely
recognized
as
an
important
risk
factor
for
the
occurrence
and
development
of
chronic
disease
(CKD).
Even
milder
AKI
adverse
consequences
could
progress
to
renal
fibrosis,
which
is
ultimate
common
pathway
various
terminal
diseases.
Thus,
it
urgent
develop
a
strategy
hinder
transition
from
CKD.
Some
mechanisms
AKI-to-CKD
have
revealed,
such
nephron
loss,
cell
cycle
arrest,
persistent
inflammation,
endothelial
with
vascular
rarefaction,
epigenetic
changes.
Previous
studies
elucidated
pivotal
role
mitochondria
in
acute
injuries
demonstrated
that
fitness
this
organelle
major
determinant
both
pathogenesis
recovery
organ
function.
Recent
research
suggested
damage
mitochondrial
function
early
crucial
leading
tubular
insufficiency.
Dysregulation
homeostasis,
alterations
bioenergetics,
stress
cross
talk
contribute
transition.
In
review,
we
focus
on
pathophysiology
after
progression
CKD,
confirming
targeting
represents
potentially
effective
therapeutic
