Extracellular vesicles in cancer — implications for future improvements in cancer care

Nature Reviews Clinical Oncology, Год журнала: 2018, Номер 15(10), С. 617 - 638

Опубликована: Май 23, 2018

Язык: Английский

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Exosomes: key players in cancer and potential therapeutic strategy

Signal Transduction and Targeted Therapy, Год журнала: 2020, Номер 5(1)

Опубликована: Авг. 5, 2020

Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in intercellular communication. The components of exosomes, including proteins, DNA, mRNA, microRNA, long noncoding RNA, circular etc., which play a crucial role regulating tumor growth, metastasis, angiogenesis the process cancer development, can be used as prognostic marker and/or grading basis for patients. Hereby, we mainly summarized followed: exosome contents cancer, focusing on proteins RNA; interaction between exosomes microenvironment; mechanisms that epithelial-mesenchymal transition, invasion migration affected exosomes; suppression strategies based exosomes. Finally, application potential clinical diagnosis therapy is prospected, providing theoretical supports using to serve precise treatment clinic.

Язык: Английский

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Exosomes in cancer development, metastasis, and immunity

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2019, Номер 1871(2), С. 455 - 468

Опубликована: Апрель 1, 2019

Язык: Английский

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Biogenesis and function of extracellular vesicles in cancer

Pharmacology & Therapeutics, Год журнала: 2018, Номер 188, С. 1 - 11

Опубликована: Фев. 21, 2018

Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes a subtype of EVs originate from limiting membrane late endosomes, as such contain information linked to both intrinsic cell "state" extracellular signals cells received their environment. Resolving affecting exosome biogenesis, cargo sorting release will increase our understanding tumorigenesis. In this review we highlight key biological processes couple biogenesis in cells. Moreover, discuss how bidirectional communication between tumor non-malignant affect metastatic behavior.

Язык: Английский

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A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum

Scientific Reports, Год журнала: 2020, Номер 10(1)

Опубликована: Янв. 23, 2020

Extracellular vesicles (EVs) are nano-sized containing nucleic acid and protein cargo that released from a multitude of cell types have gained significant interest as potential diagnostic biomarkers. Human serum is rich source readily accessible EVs; however, the separation EVs proteins non-EV lipid particles represents considerable challenge. In this study, we compared most commonly used isolation techniques, either alone or in combination, for 200 µl human their present serum. The size yield isolated by each method was determined nanoparticle tracking analysis, with variation particle distribution being to determine relative impact lipoproteins aggregates on EV population. Purification soluble calculating ratio count concentration. Finally, lipoprotein co-isolated Western blot analysis markers APOB APOE. Overall, study reveals choice procedure significantly impacts serum, together presence contaminants.

Язык: Английский

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Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance

Molecular Cancer, Год журнала: 2019, Номер 18(1)

Опубликована: Март 30, 2019

The tumor microenvironment represents a complex network, in which cells not only communicate with each other but also stromal and immune cells. Current research has demonstrated the vital role of supporting phenotype via sophisticated system intercellular communication through direct cell-to-cell contact or by classical paracrine signaling loops cytokines growth factors. Recently, extracellular vesicles have emerged as an important mechanism cellular interchange bioactive molecules. Extracellular isolated from been implicated various steps progression, such proliferation, angiogenesis, metastasis, drug resistance. Inhibition secretion, thus transfer oncogenic molecules, holds promise for preventing This review focuses on modulating addressing different aspects bidirectional interactions among tumor-associated contribution to resistance will be discussed well therapeutic strategies targeting production treatment cancer.

Язык: Английский

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The evolving translational potential of small extracellular vesicles in cancer

Nature reviews. Cancer, Год журнала: 2020, Номер 20(12), С. 697 - 709

Опубликована: Сен. 21, 2020

Язык: Английский

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Context-specific regulation of extracellular vesicle biogenesis and cargo selection

Nature Reviews Molecular Cell Biology, Год журнала: 2023, Номер 24(7), С. 454 - 476

Опубликована: Фев. 10, 2023

Язык: Английский

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Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment

Molecular Cancer, Год журнала: 2018, Номер 17(1)

Опубликована: Апрель 20, 2018

Exosomes are extracellular vesicles released by many cell types and have been attributed for their roles in diseases including cancer. secreted tumor cells stromal critical mediators of intercellular communication microenvironments. Long noncoding RNAs (lncRNAs) selectively sorted into exosomes can regulate cancer onset progression a variety ways. In this review, we summarize the characteristics exosomal lncRNAs dysregulation multiple We provide an overview current research on microenvironments, especially functions regulating biology. A deeper understanding role microenvironment may help new diagnostic prognostic markers

Язык: Английский

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Isolation and characterization of exosomes for cancer research

Journal of Hematology & Oncology, Год журнала: 2020, Номер 13(1)

Опубликована: Ноя. 10, 2020

Abstract Exosomes are a subset of extracellular vesicles that carry specific combinations proteins, nucleic acids, metabolites, and lipids. Mounting evidence suggests exosomes participate in intercellular communication act as important molecular vehicles the regulation numerous physiological pathological processes, including cancer development. released by various cell types under both normal conditions, they can be found multiple bodily fluids. Moreover, carrying wide variety macromolecules provide window into altered cellular or tissue states. Their presence biological fluids renders them an attractive, minimally invasive approach for liquid biopsies with potential biomarkers diagnosis, prediction, surveillance. Due to their biocompatibility low immunogenicity cytotoxicity, have clinical applications development innovative therapeutic approaches. Here, we summarize recent advances technologies exosome isolation research. We outline functions regulating tumor metastasis, drug resistance, immune modulation context Finally, discuss prospects challenges exosome-based therapeutics.

Язык: Английский

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