Long non-coding RNA XIST: a novel oncogene in multiple cancers

Molecular Medicine, Год журнала: 2021, Номер 27(1)

Опубликована: Дек. 1, 2021

Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. abnormally expressed numerous tumors, most of which functions as oncogene. involved multiple aspects carcinogenesis, including tumor onset, progression, and prognosis. In our review, we collected analyzed recent studies on impact human development. The multilevel molecular tumors are comprehensively reviewed to clarify pathologic mechanisms offer a novel direction for further study.

Язык: Английский

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Long Non-Coding RNAs in Diagnosis, Treatment, Prognosis, and Progression of Glioma: A State-of-the-Art Review

Frontiers in Oncology, Год журнала: 2021, Номер 11

Опубликована: Июль 12, 2021

Glioma is the most common malignant central nervous system tumor with significant mortality and morbidity. Despite considerable advances, exact molecular pathways involved in progression are not fully elucidated, patients commonly face a poor prognosis. Long non-coding RNAs (lncRNAs) have recently drawn extra attention for their potential roles different types of cancer as well non-malignant diseases. More than 200 lncRNAs been reported to be associated glioma. We aimed assess investigated stages mediating addition clinical applications. formation, invasion, progression, including regulating cell cycle, apoptosis, autophagy, epithelial-to-mesenchymal transition, stemness, angiogenesis, integrity blood-tumor-brain barrier, metabolism, immunological responses. The well-known oncogenic lncRNAs, which upregulated glioma, H19 , HOTAIR PVT1 UCA1 XIST CRNDE FOXD2-AS1 ANRIL HOXA11-AS TP73-AS1 DANCR . On other hand, MEG3 GAS5 CCASC2 TUSC7 suppressor downregulated. While studies effects MALAT1 TUG1 NEAT1 there some controversies regarding these lncRNAs. Expression levels can grade, survival, treatment response (chemotherapy drugs or radiotherapy), overall Moreover, circulatory such MALAT1, H19, HOTAIR, NEAT1, TUG1, GAS5, LINK-A provide non-invasive diagnostic prognostic tools. Modulation expression using antisense oligonucleotides lead novel therapeutics. Notably, profound understanding underlying function required develop therapeutic targets. investigations large sample sizes increased focus on in-vivo models expand our application

Язык: Английский

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Advances in the Molecular Landscape of Lung Cancer Brain Metastasis

Cancers, Год журнала: 2023, Номер 15(3), С. 722 - 722

Опубликована: Янв. 24, 2023

Lung cancer is one of the most frequent tumors that metastasize to brain. Brain metastasis (BM) common in advanced cases, being major cause patient morbidity and mortality. BMs are thought arise via seeding circulating tumor cells into brain microvasculature. In tissue, interaction with immune promotes a microenvironment favorable growth cells. Despite multimodal treatments advances systemic therapies, lung patients still have poor prognoses. Therefore, there an urgent need identify molecular drivers BM clinically applicable biomarkers order improve disease outcomes survival. The goal this review summarize current state knowledge on mechanisms metastatic spread how influenced by microenvironment, elucidate determinants regarding role genomic transcriptomic changes, including coding non-coding RNAs. We also present overview therapeutics novel treatment strategies for diagnosed from NSCLC.

Язык: Английский

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Transcription Factor NFAT5 Promotes Glioblastoma Cell-driven Angiogenesis via SBF2-AS1/miR-338-3p-Mediated EGFL7 Expression Change

Frontiers in Molecular Neuroscience, Год журнала: 2017, Номер 10

Опубликована: Сен. 21, 2017

Glioblastoma (GBM) is the most aggressive primary intracranial tumor of adults and confers a poor prognosis due to high vascularization. Hence anti-angiogenic therapy has become promising strategy for GBM treatment. In this study, transcription factor nuclear activated T-cells 5 (NFAT5) was significantly elevated in glioma samples cell lines, positively correlated with WHO grades. Knockdown NFAT5 inhibited cell-driven angiogenesis. Furthermore, long non-coding RNA SBF2 antisense 1 (SBF2-AS1) upregulated knockdown SBF2-AS1 impaired GBM-induced Downregulation decreased expression at transcriptional level. addition, repressed angiogenesis via enhancing inhibitory effect miR-338-3p on EGF like domain multiple 7 (EGFL7). vivo study demonstrated that combination produced smallest xenograft volume lowest microvessel density. NFAT5/SBF2-AS1/miR-338-3p/EGFL7 pathway may provide novel targets

Язык: Английский

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lncRNA FAM83H‑AS1 is associated with the prognosis of colorectal carcinoma and promotes cell proliferation by targeting the Notch signaling pathway

Oncology Letters, Год журнала: 2017, Номер unknown

Опубликована: Дек. 5, 2017

The long non‑coding RNA, FAM83H antisense RNA 1 (head to head) (FAM83H‑AS1), has exhibited a functional role as an oncogene in number of different types cancer. aim the present study was reveal dysregulation FAM83H‑AS1 colorectal carcinoma (CRC) samples and elucidate its underlying associations with Notch signaling pathway. expression profiles two signaling‑associated molecules, Notch1 Hes family basic‑helix‑loop‑helix transcription factor (Hes1), were measured by reverse transcription‑polymerase chain reaction western blot analysis. Pearson χ2 test employed evaluate between clinical features. A statistically significant positive association levels those or Hes1 CRC tissues analyzed Spearman's correlation Kaplan‑Meier method used compare overall survival curves highly‑expressed low‑expressed groups via log‑rank test. Specific small hairpin transfected silence endogenous FAM83H‑AS1. MTT colony formation assays performed measure growth‑inhibition effect silenced FAM83H‑AS1, significantly increased cell lines. Cell proliferation markedly inhibited when knocked down this mediated could be reversed regulators. Thus, downregulated anti‑proliferative repressing

Язык: Английский

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