Vitamin D Receptor Regulates Oxidative Stress and Apoptosis Via the HIF-1α/HO-1 Pathway in Cardiomyocytes

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Язык: Английский

---

Acute hypoxia modulate macrophage phenotype accompanied with transcriptome re-programming and metabolic re-modeling

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 17, 2025

Introduction Macrophages, which tend to aggregate in the hypoxic regions of tissues, have a significant impact on disease progression and outcome because their plastic responsiveness hypoxia, particularly early stages. Understanding macrophages’participation hypoxia-related disorders requires demonstrating acute hypoxia survival, phenotype, function. Methods Here we conducted systematic evaluation macrophage responses over 24 48 h including cell growth activity, inflamatory response, polarization transcriptional metabolic changes. Results We found that suppresses proliferation phagocytosis function with parallel change transcriptome re-programming re-modeling. Although macrophages accumulate heterogeneity based oxygen concentration culture period, genes involved chemotaxis, glycolytic process were commonly altered during hypoxia. Furthermore, pro-inflammatory response was activated concomitantly an enhanced anti-inflammatory regulatory mechanism characterized by increased M2 population metabolite itaconic acid. Aside from glycolysis, key intermediates pentose phosphate pathway significantly increased, such as fructose 1,6-bisphosphate (fold change: 7.8), 6-phosphogluconate 6.1), ribose 5-phosphate 3.9), indicated important compensatory regulation rules for Discussion These findings highlight viability phagocytosis, while modifies metabolome specific inflammatory pathways facilitate adaptation conditions.

Язык: Английский

---

Emerging Role of Hypoxia-Inducible Factors (HIFs) in Modulating Autophagy: Perspectives on Cancer Therapy

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1752 - 1752

Опубликована: Фев. 19, 2025

Hypoxia-inducible factors (HIFs) are master regulators of cellular responses to low oxygen levels and modulate autophagy, a conserved process essential for maintaining homeostasis. Under hypoxic conditions, HIFs regulate the expression autophagy-related genes influence autophagic flux stress responses. Dysregulated hypoxia-induced autophagy promotes cancer cell survival, metabolism, metastasis, thereby contributing treatment resistance. Targeting HIF-mediated pathways or modulating processes offers potential improve traditional therapies overcome drug Pharmacological inhibitors either alone in combination with other treatments, may disrupt pro-survival mechanisms within tumor microenvironment. Further research is needed elucidate intricate interplay between HIF signaling machinery cells. Understanding these could pave way novel therapeutic strategies enhance outcomes combat This review highlights complex relationship development therapy, offering insights into how targeting patient outcomes.

Язык: Английский

---

Phytomolecules are multi targeted: Understanding the interlinking pathway of Antioxidant, Anti inflammatory and Anti cancer response

Опубликована: Март 1, 2025

Язык: Английский

---

Unveiling the potential of xanthines, discovery of potential 7-benzyl-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione derivatives with antifibrotic activity for liver injury

Bioorganic Chemistry, Год журнала: 2025, Номер 160, С. 108441 - 108441

Опубликована: Апрель 5, 2025

Язык: Английский

---