Microbial Therapeutics in Oncology: A Comprehensive Review of Bacterial Role in Cancer Treatment DOI Open Access

Radha Kunjalwar,

Akshunna Keerti,

Achal Chaudhari

и другие.

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Окт. 6, 2024

Conventional cancer therapies, including chemotherapy, radiotherapy, and immunotherapy, have significantly advanced treatment. However, these modalities often face limitations such as systemic toxicity, lack of specificity, the emergence resistance. Recent advancements in genetic engineering synthetic biology rekindled interest using bacteria a novel therapeutic approach oncology. This comprehensive review explores potential microbial therapeutics, particularly bacterial treatment cancer. Bacterial therapies offer several unique advantages, ability to selectively target colonize hypoxic necrotic regions tumors, areas typically resistant conventional treatments. The delves into mechanisms through which exert antitumor effects, direct tumor cell lysis, modulation immune response, delivery agents like cytotoxins enzymes. Various species, Salmonella, Clostridium, Lactobacillus, Listeria, shown promise preclinical clinical studies, demonstrating diverse action potential. Moreover, discusses challenges associated with safety concerns, evasion, need for precise targeting, how recent advances are being used overcome hurdles. Current trials combination strategies also highlighted provide overview ongoing developments this field. In conclusion, while therapeutics present promising avenue treatment, further research validation is required fully realize their aims inspire exploration oncology, paving way innovative more effective therapies.

Язык: Английский

Liposomes as Immunotherapeutic Carriers: A Game-Changer in Cancer Therapy DOI

Sepehr Hoseinzadeh Moghaddam,

Abulfazl Vatankhah,

Fatemeh Oroojalian

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106847 - 106847

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Bacteriophage-Based Therapies in Oral Cancer: A New Frontier in Oncology DOI Creative Commons

Vishnu Priya Panneerselvam,

Leela Kagithakara Vajravelu,

Rahul Harikumar Lathakumari

и другие.

Cancer Pathogenesis and Therapy, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Current Research in Drug-Free Cancer Therapies DOI Creative Commons

Akshaya Andavar,

Varsha Rajesh Bhagavathi,

J Cousin

и другие.

Bioengineering, Год журнала: 2025, Номер 12(4), С. 341 - 341

Опубликована: Март 26, 2025

Cancer treatment has historically depended on conventional methods like chemotherapy, radiation, and surgery; however, these strategies frequently present considerable limitations, including toxicity, resistance, negative impacts healthy tissues. In addressing challenges, drug-free cancer therapies have developed as viable alternatives, utilizing advanced physical biological to specifically target tumor cells while reducing damage normal This review examines several strategies, such high-intensity focused energy beams, nanosecond pulsed electric fields, photothermal therapy well the use of inorganic nanoparticles promote selective apoptosis. We also investigate significance targeting microenvironment, precision medicine, immunotherapy in progression personalized therapies. Although approaches demonstrate significant promise, challenges scalability, safety, regulatory obstacles must be resolved for clinical application. paper presents an overview current research therapies, emphasizing recent advancements, underlying scientific principles, steps required implementation.

Язык: Английский

Процитировано

0
Dual-pathway tumor radiosensitization strategy based on engineered bacteria capable of targeted delivery of AuNPs and specific hypoxia alleviation DOI Creative Commons

Lingling Lei,

Haonan Xu,

Mingjie Li

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 29, 2025

Radiotherapy efficacy remains constrained by two key challenges: dose-dependent toxicity to healthy tissues at high radiation doses and hypoxia-mediated tumor radioresistance. While radiosensitizers like gold nanoparticles can enhance tumor-specific deposition, their targeted delivery tumors presents a significant hurdle. Bacteria have emerged as promising bio-carriers that not only actively target penetrate complex microenvironments, but also be genetically engineered multifunctional platforms for radiosensitizer hypoxia alleviation. An integrated nanosystem (PCM@AuNPs), composed of bacteria (PCM) (AuNPs), is used increase the effectiveness radiotherapy. PCM colonize sites more effectively, thus improving efficiency radiosensitizers. Furthermore, overexpresses catalase (CAT), which decomposes excess H2O2 into O2, helping mitigate in TME. Under X-ray irradiation, PCM@AuNPs significantly radiosensitization, leading improved growth inhibition while maintaining good biocompatibility. effective strategy based on an (PCM@AuNPs) radiosensitization through multiple pathways developed. This novel bacterial holds great promise enhancing cancer therapy.

Язык: Английский

Процитировано

0
Harnessing of Staphylococcus aureus Bacterial Ghosts Loaded with Docetaxel Nanoparticles for Treatment of Breast Cancer DOI
Mounir M. Salem‐Bekhit, Mohammed M. Almutairi, Mohamed Abbas Ibrahim

и другие.

Journal of Pharmaceutical Innovation, Год журнала: 2025, Номер 20(2)

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Enhancing photothermal therapy of tumors with image-guided thermal control of gene-expressing bacteria DOI Creative Commons
Fengyi Zeng, Meng Du, Yaozhang Yang

и другие.

Theranostics, Год журнала: 2024, Номер 14(15), С. 5945 - 5964

Опубликована: Янв. 1, 2024

Bacteria-mediated tumor therapy has showed promising potential for cancer therapy. However, the efficacy of bacterial monotherapy treatment which can express and release therapeutic proteins in tumors been found to be unsatisfactory. To date, synergistic emerged as a approach achieve stronger outcomes compared monotherapy. It is challenge visualize these tumor-homing bacteria

Язык: Английский

Процитировано

2
Microbial Therapeutics in Oncology: A Comprehensive Review of Bacterial Role in Cancer Treatment DOI Open Access

Radha Kunjalwar,

Akshunna Keerti,

Achal Chaudhari

и другие.

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Окт. 6, 2024

Conventional cancer therapies, including chemotherapy, radiotherapy, and immunotherapy, have significantly advanced treatment. However, these modalities often face limitations such as systemic toxicity, lack of specificity, the emergence resistance. Recent advancements in genetic engineering synthetic biology rekindled interest using bacteria a novel therapeutic approach oncology. This comprehensive review explores potential microbial therapeutics, particularly bacterial treatment cancer. Bacterial therapies offer several unique advantages, ability to selectively target colonize hypoxic necrotic regions tumors, areas typically resistant conventional treatments. The delves into mechanisms through which exert antitumor effects, direct tumor cell lysis, modulation immune response, delivery agents like cytotoxins enzymes. Various species, Salmonella, Clostridium, Lactobacillus, Listeria, shown promise preclinical clinical studies, demonstrating diverse action potential. Moreover, discusses challenges associated with safety concerns, evasion, need for precise targeting, how recent advances are being used overcome hurdles. Current trials combination strategies also highlighted provide overview ongoing developments this field. In conclusion, while therapeutics present promising avenue treatment, further research validation is required fully realize their aims inspire exploration oncology, paving way innovative more effective therapies.

Язык: Английский

Процитировано

1