Elsevier eBooks, Год журнала: 2023, Номер unknown, С. 526 - 539
Опубликована: Май 26, 2023
Язык: Английский
Annals of Neurology, Год журнала: 2024, Номер 95(4), С. 653 - 664
Опубликована: Фев. 26, 2024
While studies suggested that locus coeruleus (LC) neurodegeneration contributes to sleep-wake dysregulation in Alzheimer's disease (AD), the association between LC integrity and circadian rest-activity patterns remains unknown. Here, we investigated relationships 24-hour rhythms, cognitive trajectories, autopsy-derived older adults with without cortical AD neuropathology.
Язык: Английский
Процитировано
8
Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 153, С. 105358 - 105358
Опубликована: Авг. 17, 2023
Язык: Английский
Процитировано
22
Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17
Опубликована: Фев. 5, 2024
Here, we review the basis of contextual memory at a conceptual and cellular level. We begin with an overview philosophical foundations traversing space, followed by theories covering material bases representations in hippocampus (engrams), exploring functional characteristics cells subfields within. Next, explore various methodological approaches for investigating engrams, emphasizing plasticity mechanisms. This leads us to discuss role neuromodulatory inputs governing these dynamic changes. then outline recent hypothesis involving noradrenergic dopaminergic projections from locus coeruleus (LC) different subregions hippocampus, sculpting representations, giving brief description neuroanatomical physiological properties LC. Finally, examine how activity LC influences processes through synaptic mechanisms alter hippocampal engrams. Overall, find that phasic activation plays important promoting new learning altering mnemonic behavioral level influence NE/DA hippocampus. These findings may provide insight into remapping updating, are potentially dysregulated certain psychiatric neurodegenerative disorders.
Язык: Английский
Процитировано
5
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Янв. 9, 2025
Abstract Background Locus coeruleus (LC) imaging using neuromelanin-sensitive (NM) MRI sequences is a promising biomarker for detecting early Alzheimer’s Disease (AD) and Parkinson’s (PD). Although semi or fully automatic approaches have been developed to estimate LC integrity by measuring its intensity, these techniques most often rely on single template built in standardized space and/or depend number of voxels be accounted that defined priori. Thus, algorithms make it impossible perform direct volumetric analyses do not properly account inter-individual anatomical variability. To fill this gap, our aim was develop new multi-atlas automated segmentation method the Automatic Segmentation Hippocampal Subfields (ASHS) software. A second investigate effects age, sex education intensity volume. Method We used cross-sectional data from 101 cognitively unimpaired older adults (mean age: 73.8±6.6 years; mean education: 13.2±3.0 58 women, 43 men) Age-Well randomized controlled trial whom high-resolution NM-MRI (T1-w with magnetization transfer; 0.3×0.3×0.75mm 3 ) standard T1-w (1×1x1mm were available. The manually segmented 30 randomly selected participants NM-MRI, MRI, bilateral segmentations fed into ASHS training pipeline generate atlas (ASHS-LC). ASHS-LC applied 71 remaining subjects segment we assessed both i) (normalized pons) ii) volume total intracranial volume). Result Five-fold cross-validation experiments revealed high accuracy relative manual (Dice coefficient 0,83±0,04). ICCs demonstrated excellent reliability (ICC = 0.99), whereas lower 0.43). significantly higher women than men (Cohen’s d 0.94, p < 0.001) while no associations age (β -0.0002, 0.98) 0.11, 0.37) found. In contrast, different between 0.10, p= 0.55) but negatively associated -0.25, 0.04) -0.27, 0.04). Lastly, statistically correlated, neither (atlas set: β 0.05, 0.78) nor 0.57; analysis -0.07, 0.55). Conclusion Overall, allows automatically accurately offers opportunity measure terms This importance since two metrics may offer complementary insights integrity, as evidenced differing influences demographic factors
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Acta Neuropathologica Communications, Год журнала: 2025, Номер 13(1)
Опубликована: Фев. 28, 2025
The locus coeruleus (LC) has been identified as a site that develops phosphorylated tau pathology earlier than cerebral cortex. We present data using high-resolution postmortem MRI and validated histopathology in controls the earliest Braak (BB) stages (BBI-BBII) LC. ex vivo provides 3D volume (quantitative), while histology reveals specificity severity burden (semi-quantitative). mapped our highly regionally specific LC onto reconstructions of same samples used (n = 11). noted significant structural subatrophy between BB 0 II (30.0% smaller volumes, p 0.0381), trend which primarily affected rostral-most (49.2% average volume, 0.0381). show on both neighboring dorsal raphe caudal (DRc), were assessed at multiple rostrocaudal levels with sensitive spatial matrices. observed accumulation I (37.6% increase, < 0.0001), may reflect change prior to presumptive cognitive impairment III. Tau was most severe middle portion (11.3% greater compared rostral LC, 0.0289) when including gradient DRc (58.2% decrease DRc, suggesting selective regional vulnerabilities nuclei. Our study represents rigorous approach investigating pathology, having sections per sublevel measure whole without missing slices histological only approach. Taken together, findings provide novel demonstrate occurring during preclinical AD stages, alongside will serve valuable references for imaging.
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101738 - 101738
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Journal of Pain, Год журнала: 2024, Номер 25(6), С. 104463 - 104463
Опубликована: Янв. 8, 2024
Язык: Английский
Процитировано
3
Current Neurology and Neuroscience Reports, Год журнала: 2023, Номер 23(12), С. 925 - 936
Опубликована: Дек. 1, 2023
Abstract Purpose of Review Performing a thorough review magnetic resonance imaging (MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer’s disease (AD), contextualizing them with current preclinical neuropathological literature. Recent Findings MRI successfully detected LC alterations AD, identifying degenerative phenomena involving this nucleus even the prodromal stages disorder. The degree disruption was also associated severity AD cortical pathology, cognitive behavioral impairment, risk clinical progression. Summary Locus coeruleus-MRI has proved to be useful tool assess central noradrenergic system vivo humans. It allowed test patients experimental hypothesis, thus confirming specific marked involvement its key pathogenetic role. coeruleus-MRI–related data might represent theoretical basis on which start developing drugs target AD.
Язык: Английский
Процитировано
7
Brain Structure and Function, Год журнала: 2024, Номер 229(5), С. 1317 - 1325
Опубликована: Апрель 16, 2024
Abstract The noradrenergic nucleus Locus Coeruleus (LC) is precociously involved in Alzheimer’s Disease (AD) pathology, and its degeneration progresses during the course of disease. Using Magnetic Resonance Imaging (MRI), researchers showed also vivo patients disruption LC, which can be observed both Mild Cognitively Impaired individuals AD demented patients. In this study, we report results a follow-up neuroradiological assessment, evaluated LC overtime group cognitively impaired patients, submitted to MRI at baseline end 2.5-year follow-up. We found that progressive vivo, involving entire associated with clinical diagnosis. Our findings parallel neuropathological ones, continuous increase neuronal death volumetric atrophy within progression Braak’s stages for neurofibrillary pathology. This supports reliability as tool exploring integrity central system neurodegenerative disorders.
Язык: Английский
Процитировано
2