Updated Clinical Practice Guidelines for the Diagnosis and Management of Long COVID

Infection and Chemotherapy, Год журнала: 2024, Номер 56(1), С. 122 - 122

Опубликована: Янв. 1, 2024

"Long COVID" is a term used to describe condition when the symptoms and signs associated with coronavirus disease 2019 (COVID-19) persist for more than three months among patients infected COVID-19; this has been reported globally poses serious public health issue. Long COVID can manifest in various forms, highlighting need appropriate evaluation management by experts from fields. However, due lack of clear clinical definitions, knowledge pathophysiology, diagnostic methods, treatment protocols, it necessary develop best standard guidelines based on scientific evidence date. We developed guideline diagnosing treating long analyzing latest research data collected start COVID-19 pandemic until June 2023, along consensus expert opinions. This provides recommendations diagnosis that be applied practice, total 32 key questions related COVID. The should comprehensive, including medical history, physical examination, blood tests, imaging studies, functional tests. To reduce risk developing COVID, vaccination antiviral during acute phase are recommended. will revised there reasonable updates availability new

Язык: Английский

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Interplay between Comorbidities and Long COVID: Challenges and Multidisciplinary Approaches

Biomolecules, Год журнала: 2024, Номер 14(7), С. 835 - 835

Опубликована: Июль 11, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID’s burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Язык: Английский

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Prevalence and correlates of severe anxiety among front-line nurses during and after the COVID-19 pandemic: a large-scale multi-center study

BMC Nursing, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 15, 2025

Язык: Английский

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Long COVID in Children, Adults, and Vulnerable Populations: A Comprehensive Overview for an Integrated Approach

Diseases, Год журнала: 2024, Номер 12(5), С. 95 - 95

Опубликована: Май 6, 2024

Long COVID affects both children and adults, including subjects who experienced severe, mild, or even asymptomatic SARS-CoV-2 infection. We have provided a comprehensive overview of the incidence, clinical characteristics, risk factors, outcomes persistent COVID-19 symptoms in encompassing vulnerable populations, such as pregnant women oncological patients. Our objective is to emphasize critical significance adopting an integrated approach for early detection appropriate management long COVID. The incidence severity can significant impact on quality life patients course disease case pre-existing pathologies. Particularly, fragile patients, presence PASC related significantly worse survival, independent from vulnerabilities treatment. It important try achieve recognition management. Various mechanisms are implicated, resulting wide range presentations. Understanding specific factors involved crucial tailoring effective interventions support strategies. Management approaches involve biopsychosocial assessments treatment comorbidities, autonomic dysfunction, well multidisciplinary rehabilitation. overall one gradual improvement, with recovery observed majority, though not all, As research long-COVID continues evolve, ongoing studies likely shed more light intricate relationship between chronic diseases, status, cardiovascular psychiatric disorders, effects This information could guide healthcare providers, researchers, policymakers developing targeted interventions.

Язык: Английский

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Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6389 - 6389

Опубликована: Июнь 9, 2024

Long COVID (LC), also referred to as Post COVID-19 Condition, Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), and other terms, represents a complex multisystem disease persisting after the acute phase COVID-19. Characterized by myriad symptoms across different organ systems, LC presents significant diagnostic management challenges. Central disorder is role low-grade inflammation, non-classical inflammatory response that contributes chronicity diversity observed. This review explores pathophysiological underpinnings LC, emphasizing importance inflammation core component. By delineating pathogenetic relationships clinical manifestations this article highlights necessity for an integrated approach employs both personalized medicine standardized protocols aimed at mitigating long-term consequences. The insights gained not only enhance our understanding but inform development therapeutic strategies could be applicable chronic conditions with similar features.

Язык: Английский

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Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

MedComm, Год журнала: 2024, Номер 5(4)

Опубликована: Март 15, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 deaths. Patients with disease (COVID-19) may suffer from diarrhea, sleep disorders, depression, even cognitive impairment, which is associated long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients COVID-19 alterations microbiota their metabolites, particularly the gut, be involved regulation of immune responses. Consumption probiotics alleviate discomfort by inflammation oxidative stress. pathophysiological process underlying alleviation COVID-19-related symptoms complications targeting unclear. In current study, we summarize latest research evidence together SARS-CoV-2 vaccine use, focus relationship between use. This work provides probiotic-based interventions improve regulating gut systemic immunity. Probiotics also used as adjuvants to efficacy.

Язык: Английский

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Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study

The Lancet Regional Health - Western Pacific, Год журнала: 2024, Номер 47, С. 101086 - 101086

Опубликована: Май 9, 2024

Язык: Английский

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Reproducibility of Genetic Risk Factors Identified for Long COVID using Combinatorial Analysis Across US and UK Patient Cohorts with Diverse Ancestries

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Abstract Background Long COVID is a major public health burden causing diverse array of debilitating symptoms in tens millions patients globally. In spite this overwhelming disease prevalence and staggering cost, its severe impact on patients’ lives intense global research efforts, study the has proved challenging due to complexity. Genome-wide association studies (GWAS) have identified only four loci potentially associated with disease, although these results did not statistically replicate between studies. A previous combinatorial analysis total 73 genes that were highly two long cohorts predominantly (>91%) white European ancestry Sano GOLD population, we sought reproduce findings independent ancestrally more All Us (AoU) population. Methods We assessed reproducibility 5,343 signatures from original AoU Because very small population sizes provide limited power findings, initially tested whether observed significant enrichment are also positively correlated cohort after controlling for substructure. Results For case frequency greater than 5% AoU, consistently (77% - 83%, p < 0.01) cohort. These encompassed 92% study. At least five found shown be individually significantly increased Rates signature strongest among self-identified patients, but observe reproducing associations black/African-American Hispanic/Latino cohorts. Signatures 11 out 13 drug repurposing candidates reproduced Conclusion demonstrate signal by analysis, broadly validating analysis. They compelling evidence much broader genetic previously through traditional GWAS This strongly supports hypothesis factors play critical role determining an individual’s susceptibility following recovery acute SARS-CoV-2 infection. It lends weight Together may help stimulate needed new precision medicine approaches effectively diagnose treat disease. first reproduction across multiple populations substantially different distributions. Given high rate populations, clinical application promote better equity. hope will confidence explore some mechanisms targets advance into novel ways accelerate discovery selection therapeutic options, both form newly discovered drugs and/or immediate prioritization coordinated investigations efficacy repurposed candidates.

Язык: Английский

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Objectifying persistent subjective cognitive impairment following COVID-19 infection: cross-sectional data from an outpatient memory-clinic in Germany

European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

Abstract Objective Subjective cognitive impairment is frequently reported by patients experiencing Post-COVID symptoms. This study aims to assess objective in attention, memory, and executive functions among these patients. Further, we investigated potential determinants of impairment. Methods In this cross-sectional study, standardized neuropsychological testing (Vienna Testing System), assessment symptom aggravation, psychiatric anamnesis, psychometrics (BDI-II, Fatigue Severity Scale) were conducted 229 who voluntarily presented our outpatient memory-clinic due subjective following COVID-19. Blood-samples collected peripheral immune markers (IL-6, CRP) APOE-ε4 genotype. Results at least one domain was present 39% the 47% showed symptoms moderate or severe depression. The APOE -ε4 allele 32% Higher rates depressive (OR = 1.41, 95%-CI 1.02–1.95) higher burden 3.29, 1.51–7.40) predicted impairment, regardless age, sex, years formal education, time since infection, medication for diabetes hypertension. severity, acute COVID-19 severity inflammation had no impact. Conclusions more likely associated with high depression rather than relatively low performance. Thus, emphasizes necessity extensive evaluation when examining clinical practice. link between does not appear be specific Therefore, depression- APOE-ε4-mediated neurodegenerative pathomechanisms might a promising therapeutical target.

Язык: Английский

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Role of toll-like receptors in post-COVID-19 associated neurodegenerative disorders?

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 26, 2025

In the intricate realm of interactions between hosts and pathogens, Toll-like receptors (TLRs), which play a crucial role in innate immune response, possess ability to identify specific molecular signatures. This includes components originating from pathogens such as SARS-CoV-2, well resulting damage-associated patterns (DAMPs), endogenous molecules released after cellular damage. A developing perspective suggests that TLRs central neuroinflammation, fundamental factor neurodegenerative conditions like Alzheimer’s Parkinson’s disease (PD). comprehensive review consolidates current research investigating potential interplay TLRs, their signaling mechanisms, processes neurodegeneration following SARS-CoV-2 infection with an aim elucidate involvement long-term neurological complications COVID-19 explore targeting means implementing intervention strategies for prevention or treatment COVID-19-associated brain outcomes.

Язык: Английский

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