Depression
and
anxiety
are
two
of
the
most
prevalent
mental
health
disorders
worldwide,
affecting
millions
individuals
across
various
age
groups,
social
categories.
While
origins
these
complex
multifaceted,
recent
advancements
in
Neuroscience
provide
valuable
insights
into
underlying
mechanisms
that
contribute
to
development
maintenance
mood
disorders.
This
review
delves
intricate
interplay
neurobiological
factors
involved
disorders,
shedding
light
on
neural
pathways,
neurotransmitters,
structural/functional
circuit
changes
their
manifestations.
A
special
focus
is
given
new
upcoming
emerge
from
a
deeper
understanding
biological
environmental
takes
place
at
multi-scale
level,
genes
behaviors.
Journal of Neuroscience and Neurological Disorders,
Год журнала:
2024,
Номер
8(2), С. 106 - 114
Опубликована: Ноя. 12, 2024
Background:
The
study
of
new
neuron
formation
in
the
adult
brain
has
sparked
controversy
and
ignited
interest
among
scientists
recent
times,
these
include
its
occurrence
location
human
brain,
functional
significance,
variation
methods,
translation
from
animal
model
to
human,
ethical
challenges
involving
neural
stem
cell
research.
Aim:
To
provide
a
comprehensive
understanding
neurogenesis,
explore
latest
advances
neurogenesis.
Methodology:
An
extensive
systematic
search
electronic
databases
(Medline,
Scopus,
Web
Science)
was
conducted
using
keywords
related
neurogenesis
techniques
involved
study.
Results:
mechanism
found
occur
specific
regions
such
as
subgranular
zone
dentate
gyrus
subventricular
lateral
ventricle.
Adult
is
vital
plasticity,
providing
potential
for
adapt
reorganize
response
environmental
cues
experiences.
Cutting-edge
research
sophisticated
imaging
techniques,
two-photon
microscopy,
MRI,
optogenetic,
stem-cell-based
therapies
have
provided
deeper
insight
into
Conclusion:
important
nervous
system
development,
physiology,
pathology,
exploring
neuroplasticity.
Its
advancement
challenged
by
some
concerns
regarding
embryonic,
pluripotent
cells,
need
safe,
noninvasive
methods.
Although
breakthroughs
neuroimaging,
microscopic
genetic
tools
are
aiding
real-time
Depression
and
anxiety
are
two
of
the
most
prevalent
mental
health
disorders
worldwide,
affecting
millions
individuals
across
various
age
groups,
social
categories.
While
origins
these
complex
multifaceted,
recent
advancements
in
Neuroscience
provide
valuable
insights
into
underlying
mechanisms
that
contribute
to
development
maintenance
mood
disorders.
This
review
delves
intricate
interplay
neurobiological
factors
involved
disorders,
shedding
light
on
neural
pathways,
neurotransmitters,
structural/functional
circuit
changes
their
manifestations.
A
special
focus
is
given
new
upcoming
emerge
from
a
deeper
understanding
biological
environmental
takes
place
at
multi-scale
level,
genes
behaviors.
