Risk of microdosing in clinical high-risk populations

Schizophrenia Research, Год журнала: 2025, Номер 277, С. 169 - 170

Опубликована: Март 1, 2025

Язык: Английский

Longitudinal associations of naturalistic psychedelic use with psychotic and manic symptoms

Psychological Medicine, Год журнала: 2025, Номер 55

Опубликована: Янв. 1, 2025

Abstract Background Findings from contemporary clinical trials suggest that psychedelics are generally safe and may be effective in the treatment of various psychiatric disorders. However, less is known about risks associated with psychedelic use outside medically supervised contexts, particularly populations typically excluded participation trials. Methods Using a preregistered longitudinal observational research design purposive sample US residents between 18 50 years old ( N =21,990), we investigated associations self-reported naturalistic psychotic manic symptoms, emphasis on those histories schizophrenia or bipolar I disorder. Results The follow-up survey was completed by 12,345 participants (56% retention), 505 reporting during 2-month study period. In covariate-adjusted regression models, period increases severity symptoms. such were only observed for who reported an illegal context. While symptoms appeared to depend frequency intensity challenging experiences, moderated personal history disorder subjective experience insight experience. Conclusions findings specifically contexts lead Such use, acute experience, history.

Язык: Английский

Naturalistic Psychedelic Use and Psychotic Symptoms: A Cross-Sectional Study of Individuals with a Personal or Family History of Psychotic or Bipolar Disorders

Psychedelic Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Язык: Английский