Mucosal Immunology, Год журнала: 2023, Номер 16(2), С. 99 - 103
Опубликована: Март 10, 2023
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Фев. 16, 2024
Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management
Язык: Английский
Процитировано
237
FEMS Microbiology Reviews, Год журнала: 2023, Номер 47(2)
Опубликована: Март 1, 2023
Abstract The human gut harbors native microbial communities, forming a highly complex ecosystem. Synthetic communities (SynComs) of the are an assembly microorganisms isolated from mucosa or fecal samples. In recent decades, ever-expanding culturing capacity and affordable sequencing, together with advanced computational modeling, started ‘‘golden age’’ for harnessing beneficial potential SynComs to fight gastrointestinal disorders, such as infections chronic inflammatory bowel diseases. As simplified completely defined microbiota, offer promising reductionist approach understanding multispecies multikingdom interactions in microbe–host-immune axis. However, there still many challenges overcome before we can precisely construct designed function efficacy that allow translation scientific findings patients’ treatments. Here, discussed strategies used design, assemble, test SynCom, address significant challenges, which microbiological, engineering, translational nature, stand way using live bacterial therapeutics.
Язык: Английский
Процитировано
59
Frontiers in Nutrition, Год журнала: 2023, Номер 10
Опубликована: Июль 17, 2023
Bioactive compounds found in edible plants and foods are vital for human planetary health, yet their significance remains underappreciated. These natural bioactives, as part of whole diets, ingredients, or supplements, can modulate multiple aspects health wellness. Recent advancements omic sciences computational biology, combined with the development Precision Nutrition, have contributed to convergence nutrition medicine, well more efficient affordable healthcare solutions that harness power food prevention therapy. Innovation this field is crucial feed a growing global population sustainably healthily. This requires significant changes our system, spanning agriculture, production, distribution consumption. As we facing pressing challenges, investing bioactive-based an opportunity protect biodiversity soils, waters, atmosphere, while also creating value consumers, patients, communities, stakeholders. Such research innovation targets include alternative proteins, such cellular agriculture plant-derived protein; extracts improve shelf-life preservatives; upcycling agricultural by-products reduce waste; alternatives synthetic fertilizers pesticides. Translational bioactives currently being developed at two levels, using systems-oriented approach. First, biological level, interplay between these host microbiome elucidated through omics research, big data artificial intelligence, accelerate both discovery validation. Second, ecosystem efforts focused on producing diverse nutrient-rich, flavorful, resilient, high-yield crops, educating consumers make informed choices benefit planet. Adopting system-oriented perspective helps: unravel intricate dynamic relationships nutrition, sustainability outcomes, harnessing nature promote wellbeing; foster sustainable ecosystem. Interdisciplinary collaboration needed new era practical food-based some most challenges humanity planet today.
Язык: Английский
Процитировано
51
Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)
Опубликована: Май 14, 2024
The gut microbiota plays a critical role in the progression of human diseases, especially cancer. In recent decades, there has been accumulating evidence connections between and cancer immunotherapy. Therefore, understanding functional regulating immune responses to immunotherapy is crucial for developing precision medicine. this review, we extract insights from state-of-the-art research decipher complicated crosstalk among microbiota, systemic system, context Additionally, as can account immune-related adverse events, discuss potential interventions minimize these effects clinical application five microbiota-targeted strategies that precisely increase efficacy Finally, holds promising target immunotherapeutics, summarize current challenges provide general outlook on future directions field.
Язык: Английский
Процитировано
34
Journal of Personalized Medicine, Год журнала: 2024, Номер 14(2), С. 217 - 217
Опубликована: Фев. 18, 2024
Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on previously overlooked player the pathogenesis of disease-the human microbiome. This review article addresses intricate relationship between microbiome infectious unravels its role as crucial mediator host-pathogen interactions. We explore remarkable potential harnessing this dynamic ecosystem develop innovative strategies that could revolutionize management diseases. By exploring latest advances emerging trends, aims provide new perspective combating by targeting
Язык: Английский
Процитировано
23
Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
8
Obesity Medicine, Год журнала: 2025, Номер unknown, С. 100585 - 100585
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
3
BMC Complementary Medicine and Therapies, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 13, 2025
The human microbiome plays a vital role in health, mediated by the gut–brain axis, with large diversity of functions and physiological benefits. dynamics mechanisms meditations on oral gut modulations are not well understood. This study investigates short-term during an Arhatic Yoga meditation retreat as improving well-being through possible gut-brain axis. A single-arm pilot clinical trial was conducted controlled environment 9-day intensive practices vegetarian diet. Oral fecal samples 24 practitioners were collected at start (Day0: T1), middle (Day3: T2), end (Day9:T3) retreat. Targeted 16S rRNA gene amplicon sequencing performed for both samples. Functional pathway predictions identified using phylogenetic investigation communities reconstruction unobserved states (PICRUSt2). DESeq2 used to identify differential abundant taxa. Various statistical analyses assess significant changes data. Our findings revealed that together diet led profiles within profile showed (p < 0.05) difference species richness evenness study, while non-metric multidimensional scaling (NMDS) confirmed shift T2 timepoint, which further supported PERMANOVA analysis 0.05). Health-benefiting microbes known improve gastrointestinal gut-barrier functions, immune modulation, axis enriched. Gut beginner advanced similar trends convergence study. implies strong selection pressure beneficial microbiome. demonstrates combined short resulted enrichment health-promoting microbes. Such microbial consortia may be developed potential health benefits probiotics systems, Study submitted https://clinicaltrials.gov/on28-02-2024 . Retrospective registered.
Язык: Английский
Процитировано
2
Microorganisms, Год журнала: 2022, Номер 10(12), С. 2427 - 2427
Опубликована: Дек. 7, 2022
Weissella is a genus earlier considered member of the family Leuconostocaceae, which was reclassified into Lactobacillaceae in 1993. Recently, there have been studies emphasizing probiotic and anti-inflammatory potential various species Weissella, W. confusa cibaria are most representative. Other within this include: paramesenteroides, viridescens, halotolerans, minor, kandleri, soli, ghanensis, hellenica, thailandensis, fabalis, cryptocerci, koreensis, beninensis, fabaria, oryzae, ceti, uvarum, bombi, sagaensis, kimchi, muntiaci, jogaejeotgali, coleopterorum, hanii, salipiscis, diestrammenae. confusa, among few that isolated from human samples, although identification these other possible using metagenomics, as we shown for inflammatory bowel disease (IBD) healthy controls. We were able to isolate gut-associated bacteria (post 24 h food deprivation laxatives). sources isolation include fermented food, soil, skin/gut/saliva insects/animals. With hospital industrial applications, concern about infections. Herein, present current applications on its antimicrobial mechanistic effects, predisposing factors (e.g., vancomycin) pathogenicity humans, antimicrobials used patients. To address medical concerns, examined 28 case reports focused found 78.5% infections bacteremia (of 7 fatal; 1 lack treatment), 8 associated with underlying malignancies, gastrointestinal procedures/diseases 2 Crohn’s In cases successful resolution, commonly administered antibiotics included: cephalosporin, ampicillin, piperacillin-tazobactam, daptomycin. Despite Weissella-related infections, evolving findings suggest clinically treatable emerging benefits ranging oral health, skin care, obesity, diseases cancer.
Язык: Английский
Процитировано
47
Gut Microbes, Год журнала: 2023, Номер 15(1)
Опубликована: Июнь 26, 2023
Humans possess abundant amounts of microorganisms, including bacteria, fungi, viruses, and archaea, in their gut. Patients with nonalcoholic fatty liver disease (NAFLD) exhibit alterations gut microbiome an impaired barrier function. Preclinical studies emphasize the significance pathogenesis NAFLD. In this overview, we explore how adjusting could serve as innovative therapeutic strategy for We provide a summary current information on untargeted techniques such probiotics fecal microbiota transplantation, well targeted microbiome-focused therapies engineered prebiotics, postbiotics, phages treatment
Язык: Английский
Процитировано
31