Growing Indoor Environmental Infrastructure: Designing for Microbial Diversity with Implications for Pollutant Metabolism and Human Health

Research Directions Biotechnology Design, Год журнала: 2024, Номер 2

Опубликована: Янв. 1, 2024

Abstract Urban inhabitants spend upwards of 90% their time indoors where building design and mechanical air-handling systems negatively impact air quality, microbiome diversity health outcomes. bioremediation infrastructure designed to improve indoor environmental quality by drawing through photosynthesizing plants metabolically diverse rhizospheres have been investigated since the 1960s; however, in-depth analysis potential impacts on environments is required: (1) although recent evidence has illustrated human alteration associated benefits related exposure green wall systems, mechanism(s) diversification not yet established, (2) microbial metabolism airborne chemical dynamics are extraordinarily complex hypotheses pertaining rhizosphere microorganisms metabolizing pollutants require more attention. To explore these areas, we applied a shotgun metagenomic approach quantify establish preliminary metabolic profiles within active modules spanning range growth media plant selections. Results indicate that fundamental decisions, including hydroponic vs. organic media, support microbiomes with distinct which could system performance. The described relationships represents an opportunity “grow” metabolisms for pollutant

Язык: Английский

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Advancing microbiota therapeutics: the role of synthetic biology in engineering microbial communities for precision medicine

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Дек. 4, 2024

Over recent years, studies on microbiota research and synthetic biology have explored novel approaches microbial manipulation for therapeutic purposes. However, fragmented information is available this aspect with key insights scattered across various disciplines such as molecular biology, genetics, bioengineering, medicine. This review aims to the transformative potential of in advancing microbiome therapies, significant implications healthcare, agriculture, environmental sustainability. By merging computer science, engineering, allows precise design modification biological systems via cutting edge technologies like CRISPR/Cas9 gene editing, metabolic oligonucleotide synthesis, thus paving way targeted treatments personalized probiotics engineered microorganisms. The will also highlight vital role gut disorders caused by its dysbiosis suggesting microbiota-based therapies innovations biosensors real-time health monitoring, non-invasive diagnostic tools, automated bio foundries better outcomes. Moreover, challenges including genetic stability, safety, robust regulatory frameworks be discussed understand importance ongoing ensure safe effective interventions.

Язык: Английский

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Predicting Personalized Responses to Dietary Fiber Interventions: Opportunities for Modulation of the Gut Microbiome to Improve Health

Annual Review of Food Science and Technology, Год журнала: 2022, Номер 14(1), С. 157 - 182

Опубликована: Ноя. 29, 2022

Inadequate dietary fiber consumption has become common across industrialized nations, accompanied by changes in gut microbial composition and a dramatic increase chronic metabolic diseases. The human microbiome harbors genes that are required for the digestion of fiber, resulting production end products mediate gastrointestinal systemic benefits to host. Thus, use interventions attracted increasing interest as strategy modulate improve health. However, considerable interindividual differences have resulted variable responses toward interventions. This variability led observed nonresponder individuals highlights need personalized approaches effectively redirect ecosystem. In this review, we summarize strategies used address responder phenomenon propose targeted approach identify predictive features based on knowledge metabolism machine learning approaches.

Язык: Английский

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Targeting gut-liver axis by dietary lignans ameliorate obesity: evidences and mechanisms

Critical Reviews in Food Science and Nutrition, Год журнала: 2023, Номер unknown, С. 1 - 22

Опубликована: Окт. 23, 2023

An imbalance between energy consumption and expenditure causes obesity. It is characterized by increased adipose accumulation accompanied chronic low-grade inflammation. Many studies have suggested that the gut microbiota of host mediates relationship high-fat diet development Diet nutrition body are heavily influenced microbiota. The alterations in may effects on homeostasis host's levels, systemic inflammation, lipid metabolism, insulin sensitivity. liver an important organ for fat metabolism gut-liver axis play role metabolism. Gut-liver a bidirectional its liver. As essential plant components, lignans been shown to different biological functions. Accumulating evidences lipid-lowering properties. Lignans can regulate level their metabolites host, thereby affecting signaling pathways related synthesis These make difference inhibiting accumulation, accelerating appetite, will provide groundwork future impact creation functional meals based those findings.

Язык: Английский

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Exposure to environmental microbiota may modulate gut microbial ecology and the immune system

Mucosal Immunology, Год журнала: 2023, Номер 16(2), С. 99 - 103

Опубликована: Март 10, 2023

Язык: Английский

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