Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder DOI Open Access
Steven J. Granger,

Víctor May,

Sayamwong E. Hammack

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Авг. 31, 2023

Pituitary adenylate cyclase-activating polypeptide (PACAP) regulates plasticity in brain systems underlying arousal and memory is associated with posttraumatic stress disorder (PTSD). Research animal models suggests that PACAP modulates entorhinal cortex (EC) input to the hippocampus, contributing impaired contextual fear conditioning. In PTSD, higher activity of amygdala threat stimuli lower functional connectivity hippocampus. However, PACAP-affiliated structural alterations these regions have not been reported. Here, we examined whether peripheral levels were neuronal morphology hippocampus (primary analysis), EC (secondary analysis) using Neurite Orientation Dispersion Density Imaging.

Язык: Английский

Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder DOI Open Access
Steven J. Granger,

Víctor May,

Sayamwong E. Hammack

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Авг. 31, 2023

Pituitary adenylate cyclase-activating polypeptide (PACAP) regulates plasticity in brain systems underlying arousal and memory is associated with posttraumatic stress disorder (PTSD). Research animal models suggests that PACAP modulates entorhinal cortex (EC) input to the hippocampus, contributing impaired contextual fear conditioning. In PTSD, higher activity of amygdala threat stimuli lower functional connectivity hippocampus. However, PACAP-affiliated structural alterations these regions have not been reported. Here, we examined whether peripheral levels were neuronal morphology hippocampus (primary analysis), EC (secondary analysis) using Neurite Orientation Dispersion Density Imaging.

Язык: Английский

Процитировано

0