Differential temporal decline of cerebral oxytocin and μ‐opioid receptor density during the aging process in mice DOI Creative Commons
Felix Effah, Prakash Nidadavolu, Nívea Karla de Gusmão Taveiros Silva

и другие.

European Journal of Neuroscience, Год журнала: 2024, Номер 60(11), С. 6686 - 6703

Опубликована: Окт. 22, 2024

Abstract Aging is often associated with changes in social, sexual, emotional and pain functioning, as well the increased prevalence of certain psychopathologies. However, neurodevelopmental basis underpinning these age‐related remains to be determined. Considering key roles oxytocin (OTR) μ‐opioid (MOPr) receptor systems regulating pain, reward processing, it seems plausible that they are also implicated behavioural alterations. Although ontogeny both receptors has been characterized rodent brains from early development till adulthood, little known concerning neuroadaptations occurring middle age old age. Therefore, we mapped OTR MOPr mice at those developmental endpoints. Quantitative autoradiographic binding was carried out male 2, 6, 9, 12 18 months A significant whole brain decline density detected between 2 6 age, no additional thereafter. Interestingly, for MOPrs, not until 9 Region‐specific concentrated lateral anterior olfactory nuclei (AOL) and, MOPr, AOL nucleus accumbens. Identifying tipping point variations may assist our understanding neurobiology underlining functioning/processing. It help us target interventions specific windows abrogate

Язык: Английский

Differential temporal decline of cerebral oxytocin and μ‐opioid receptor density during the aging process in mice DOI Creative Commons
Felix Effah, Prakash Nidadavolu, Nívea Karla de Gusmão Taveiros Silva

и другие.

European Journal of Neuroscience, Год журнала: 2024, Номер 60(11), С. 6686 - 6703

Опубликована: Окт. 22, 2024

Abstract Aging is often associated with changes in social, sexual, emotional and pain functioning, as well the increased prevalence of certain psychopathologies. However, neurodevelopmental basis underpinning these age‐related remains to be determined. Considering key roles oxytocin (OTR) μ‐opioid (MOPr) receptor systems regulating pain, reward processing, it seems plausible that they are also implicated behavioural alterations. Although ontogeny both receptors has been characterized rodent brains from early development till adulthood, little known concerning neuroadaptations occurring middle age old age. Therefore, we mapped OTR MOPr mice at those developmental endpoints. Quantitative autoradiographic binding was carried out male 2, 6, 9, 12 18 months A significant whole brain decline density detected between 2 6 age, no additional thereafter. Interestingly, for MOPrs, not until 9 Region‐specific concentrated lateral anterior olfactory nuclei (AOL) and, MOPr, AOL nucleus accumbens. Identifying tipping point variations may assist our understanding neurobiology underlining functioning/processing. It help us target interventions specific windows abrogate

Язык: Английский

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