Exploring the effects of adolescent social isolation stress on the serotonin system and ethanol-motivated behaviors DOI Creative Commons

Bryan D. McElroy,

Chen Li,

Nicholas McCloskey

и другие.

Psychopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Abstract Rationale Alcohol is one of the most frequently used drugs abuse and has a major impact on human health worldwide. People assigned female at birth those with adverse childhood experiences are stress-vulnerable more likely to report drinking as means “self-medication.” Prior studies in our laboratory showed that adolescent social isolation stress (SIS) increases vulnerability ethanol (EtOH) intake consumption despite negative consequences rats. Objectives Here, we explored modulation dorsal raphe nucleus (DRN)-serotonin (5-HT) system, sexually dimorphic neurotransmitter system involved stress-reward interactions, determine its contribution EtOH-motivated behaviors rats have undergone SIS. Results We employed electrophysiological functional neuroanatomy strategies show both SIS EtOH exposure induce persistent hypofunction DRN 5-HT particularly females. Chemogenetic activation neurons attenuated reward value for sucrose elevated punished responding stress-dependent manner. Conclusions Our results highlight an inverse relationship between sex- nature this relationship, connection signaling acute rewards punishment. These data support potential target treat aberrant alcohol populations.

Язык: Английский

Exploring the effects of adolescent social isolation stress on the serotonin system and ethanol-motivated behaviors DOI Creative Commons

Bryan D. McElroy,

Chen Li,

Nicholas McCloskey

и другие.

Psychopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Abstract Rationale Alcohol is one of the most frequently used drugs abuse and has a major impact on human health worldwide. People assigned female at birth those with adverse childhood experiences are stress-vulnerable more likely to report drinking as means “self-medication.” Prior studies in our laboratory showed that adolescent social isolation stress (SIS) increases vulnerability ethanol (EtOH) intake consumption despite negative consequences rats. Objectives Here, we explored modulation dorsal raphe nucleus (DRN)-serotonin (5-HT) system, sexually dimorphic neurotransmitter system involved stress-reward interactions, determine its contribution EtOH-motivated behaviors rats have undergone SIS. Results We employed electrophysiological functional neuroanatomy strategies show both SIS EtOH exposure induce persistent hypofunction DRN 5-HT particularly females. Chemogenetic activation neurons attenuated reward value for sucrose elevated punished responding stress-dependent manner. Conclusions Our results highlight an inverse relationship between sex- nature this relationship, connection signaling acute rewards punishment. These data support potential target treat aberrant alcohol populations.

Язык: Английский

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