Expert Opinion on Therapeutic Targets,
Год журнала:
2024,
Номер
unknown, С. 1 - 27
Опубликована: Дек. 23, 2024
Introduction
Ischemic
stroke
(IS),
a
major
cause
of
mortality
and
disability
worldwide,
remains
significant
healthcare
challenge
due
to
limited
therapeutic
options.
Ferroptosis,
distinct
iron-dependent
form
regulated
cell
death
characterized
by
lipid
peroxidation
oxidative
stress,
has
emerged
as
crucial
mechanism
in
IS
pathophysiology.
This
review
explores
the
role
ferroptosis
its
potential
for
driving
innovative
strategies.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10468 - 10468
Опубликована: Сен. 28, 2024
Iron
plays
a
crucial
role
in
various
metabolic
processes.
However,
the
impact
of
5-aminolevulinic
acid
(ALA)
combination
with
iron
chelators
on
metabolism
and
efficacy
ALA-photodynamic
therapy
(PDT)
remain
inadequately
understood.
This
study
aimed
to
examine
effect
thiosemicarbazone
derivatives
during
ALA
treatment
specific
genes
related
metabolism,
particular
emphasis
mitochondrial
genes.
In
our
study,
we
observed
differences
depending
cell
line
studied.
For
HCT116
MCF-7
lines,
most
cases,
decrease
expression
selected
targets
correlated
increase
protoporphyrin
IX
(PPIX)
concentration
photodynamic
effect,
aligning
existing
literature
data.
The
Hs683
showed
different
gene
pattern,
previously
not
described
literature.
this
collected
an
extensive
analysis
variation
occurring
after
application
novel
presented
versatile
effective
compounds
great
potential
for
use
ALA-PDT.
Biofabrication,
Год журнала:
2024,
Номер
17(1), С. 012009 - 012009
Опубликована: Дек. 6, 2024
Reduced
therapy
response
in
breast
cancer
has
been
correlated
with
heterogeneity
biomarker
composition,
expression
level,
and
spatial
distribution
of
cells
within
a
patient
tumor.
Thus,
there
is
need
for
models
to
replicate
cell-cell,
cell-stromal,
cell-microenvironment
interactions
during
progression.
Traditional
two-dimensional
(2D)
cell
culture
are
convenient
but
cannot
adequately
represent
tumor
microenvironment
histological
organization,in
vivo3D
spatial/cellular
context,
physiological
relevance.
Recently,
three-dimensional
(3D)in
vitrotumor
have
shown
provide
an
improved
platform
incorporating
compositional
better
mimic
the
biological
characteristics
tumors
assess
drug
response.
Advances
3D
bioprinting
allowed
creation
more
complex
physiologic
representation
while
controlling
reproducibility
accuracy.
This
review
aims
summarize
advantages
challenges
current
3Din
vitromodels
evaluating
cancer,
particular
emphasis
on
bioprinting,
addresses
several
key
issues
future
model
development
as
well
their
application
other
cancers.
Expert Opinion on Therapeutic Targets,
Год журнала:
2024,
Номер
unknown, С. 1 - 27
Опубликована: Дек. 23, 2024
Introduction
Ischemic
stroke
(IS),
a
major
cause
of
mortality
and
disability
worldwide,
remains
significant
healthcare
challenge
due
to
limited
therapeutic
options.
Ferroptosis,
distinct
iron-dependent
form
regulated
cell
death
characterized
by
lipid
peroxidation
oxidative
stress,
has
emerged
as
crucial
mechanism
in
IS
pathophysiology.
This
review
explores
the
role
ferroptosis
its
potential
for
driving
innovative
strategies.
